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Administrative Supplement to 1 UG3 NS106938-02: “NIBA-TBI: Neuro-Imaging and biofluid-based Biomarker Assessments as translational pathophysiological outcome measures in TBI

Administrative Supplement to 1 UG3 NS106938-02: “NIBA-TBI: Neuro-Imaging and biofluid-based Biomarker Assessments as translational pathophysiological outcome measures in TBI
1 UG3 NS106938-02 的行政补充:-NIBA-TBI:神经成像和基于生物流体的生物标志物评估作为 TBI 转化病理生理学结果测量
批准号:
10004822
负责人:
KEVIN Ka Wang WANG
金额:
$2.26万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-09-15 至 2020-03-31

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中文摘要
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摘要/摘要(行政补充)
英文摘要
Summary / Abstract (Administrative Supplement) Consistent with the vision of the Translational Outcomes Project in Neurotrauma (TOPNT) (UG3/UH3) RFA, we assembled a multidisciplinary team and proposed to evaluate two complementary pathological mechanism- based TBI outcome measures – (i) biofluid biomarker assessment, and (ii) MRI-neuroimaging biomarker assessment. The objective of this administrative supplement is to facilitate cross-site harmonization and validation of neuroimaging and biofluid-based biomarker methods across the 4 funded study centers. We have the following supplementary aims: Supplementary Aim A1: To develop and optimize a multiparametric MRI protocol that completely meets needs for all labs in the consortium and to determine cross-lab measurement reproducibility on MRI calibration phantoms, live healthy control rats, and ex vivo rat brains. Supplementary Aim B1- Subject purified rat, and/or mouse and human GFAP and their calpain and caspase-digest to different measurement assays using western blot, ELISA and mass spectrometry at the two UG3 TOP-NT biomarker lab (UCLA, and UF). Supplementary Aim B2- At both UF and UCLA sites, terminal animal biosamples (control, injured) will be examined with the above GFAP assay approaches.
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Persistent Pre- and Post-Synaptic Changes After Moderate Traumatic Brain Injury and Mitigation with MitoQ
  • 批准号:
    10643137
  • 项目类别:
  • 资助金额:
    $0.0万
  • 财政年份:
    2023
  • 负责人:
    KEVIN Ka Wang WANG
  • 依托单位:
Mild Traumatic Brain Injury and Opiate Exposure Crosstalk: Neuropathological, Neurobehavioral, and Neuroproteomic Assessments
  • 批准号:
    10051334
  • 项目类别:
  • 资助金额:
    $0.0万
  • 财政年份:
    2019
  • 负责人:
    KEVIN Ka Wang WANG
  • 依托单位:
Mild Traumatic Brain Injury and Opiate Exposure Crosstalk: Neuropathological, Neurobehavioral, and Neuroproteomic Assessments
  • 批准号:
    10614983
  • 项目类别:
  • 资助金额:
    $0.0万
  • 财政年份:
    2019
  • 负责人:
    KEVIN Ka Wang WANG
  • 依托单位:
NIBA-TBI: Neuro-Imaging and biofluid-based Biomarker Assessments as translational pathophysiological outcome measures in TBI
  • 批准号:
    9548010
  • 项目类别:
  • 资助金额:
    $37.39万
  • 财政年份:
    2018
  • 负责人:
    KEVIN Ka Wang WANG
  • 依托单位:
海外基金