Delineation of the biopsychosocial risks of obesogenic eating behaviors

肥胖饮食行为的生物心理社会风险的描述

基本信息

批准号：
10025182
负责人：
Ying Meng
金额：
$ 15.43万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-25 至 2022-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10025182
关键词：
3 year old Address Adolescent Adult Adverse effects Age Applied Research Area Award Behavior Therapy Behavior assessment Behavioral Biological Biometry Brain-Derived Neurotrophic Factor Calories Child Child Development Child Health Childhood Clinic Clinical Collection Data Development Diet Discipline of Nursing Distal Doctor of Philosophy Eating Behavior Emotional Epidemic Family First Pregnancy Trimester Food Foundations Funding Future Gene-Modified Genes Genetic Genetic Risk Genotype Goals Grant Hair Health Health behavior Healthy Eating Human Genetics Human Subject Research Hydrocortisone Hyperphagia Infrastructure Intervention Intervention Studies K-Series Research Career Programs Knowledge LEPR gene Learning Longitudinal Studies Measurement Mediating Mentored Patient-Oriented Research Career Development Award Mentorship Methods Modeling Molecular Biology NTRK2 gene Nature Nurses Nursing Research Nutrition Assessment Obesity Observational Study Outcome Parents Perinatal Physiological Positioning Attribute Precision Health Preparation Proxy Psychological reinforcement Psychosocial Stress Public Health Reporting Research Research Design Research Methodology Research Personnel Risk Sampling Science Scientist Stress Testing Time Training Training and Infrastructure Translational Research United States National Institutes of Health Visit Work base biopsychosocial care giving burden career caregiving comparative cost efficient early childhood early life stress early-onset obesity ethnic diversity experience genetic analysis genetic makeup genome-wide analysis human genomics improved novel nutrition obesity genetics obesity in children obesity management obesity risk obesogenic patient oriented research preference prevent programs psychosocial risk variant skills stress management

项目摘要

This K23 proposal prepares the applicant Ying Meng, PhD, RN, for a clinical and translational nursing research career centered on preventing and reducing childhood obesity and its adverse effects on health. As such, I commit to a career of clinical and translational nursing research that combines an understanding of behavioral, psychosocial, and genetic/biological knowledge to develop observational and interventional research to advance the emerging field of precision health in obesity management. My focus in this K23 application on childhood obesogenic eating behaviors (OEBs) reflects the supporting science and addresses an important gap in my developing expertise. An understanding of OEBs requires knowledge in behavioral, psychosocial, and genetic methods and findings pertaining to obesity. I am extremely well-positioned to contribute to this area of study because I have a strong research foundation in human genetics and molecular biology with enriched training in biostatistics and extensive clinical experience in nursing practice. These skills will be further enhanced by this K23 award under the guidance of my strong mentorship team with expertise in child development, stress exposure, pediatric obesity, genetics, nursing, nutrition, and biostatistics. The specific research aims are to (1) characterize OEBs in young children using observational, parent-report, and child- report methods; (2) identify concurrent psychosocial and physiological stress markers for OEBs in young children; (3) examine associations between previously identified obesity-risk genes and OEBs in young children. We will assess obesogenic eating behaviors in 3-year-old children from families who have been participating in an ongoing longitudinal study of perinatal influences on child health and development. This NIH-funded “parent” study will offer direct, substantial and long-term support and provide a well-organized infrastructure for my proposal, which makes this K23 application very time- and cost-efficient. This award will enable me to attain essential expertise in behavioral, psychosocial, and biological assessments related to OEBs in young children, research methodology in pediatric clinic samples, and behavioral and intervention- relevant research on childhood obesity. My training goals for this K23 award are to (1) gain experience and didactic learning in study design and execution of human subject research; (2) broaden my knowledge and experience of OEBs and nutrition assessments for the current project and interventions for childhood obesity for future projects; (3) gain experience in early-life stress measurements and stress management strategies in young children; (4) expand my knowledge and analytical skills in advanced human genomics; (5) professional development; and (6) grantsmanship in preparation for subsequent R grant. By the end of the award period, I will be prepared to launch an independent patient-oriented research career to conduct observational and interventional research to reduce the epidemic of pediatric obesity.

该K23提案为申请人Ying Meng，PhD，RN准备了临床和翻译的护士研究职业集中在防止和减少儿童对象及其对健康的不利影响。这样，我致力从事临床和翻译护士研究的职业，该研究结合了对行为的理解，社会心理和遗传/生物学知识，以开发观察性和介入研究在观察管理中推进精确健康的新兴领域。我将重点放在K23上儿童时期的肥胖饮食行为（OEB）反映了支持科学，并解决了重要的在我发展的专业知识中差距。对OEB的理解需要在行为，社会心理，以及与肥胖有关的遗传方法和发现。我对此做出了良好的贡献研究领域是因为我在人类遗传学和分子生物学方面具有强大的研究基础在生物统计学和护士实践方面的丰富临床经验方面的培训丰富。这些技能将是在我坚强的Mentalship团队的指导下，该K23奖的专业知识进一步增强了发育，压力暴露，小儿肥胖，遗传学，护士，营养和生物统计学。具体研究目的是（1）使用观察性，父母报告和儿童来表征幼儿的OEB 报告方法；（2）确定年轻的OEB的并发心理和身体压力标记孩子们; （3）检查年轻的肥胖风险基因与OEB之间的关联孩子们。我们将评估来自曾经的家庭的3岁儿童的肥胖饮食行为参加对围产期影响儿童健康和发育的持续纵向研究。这 NIH资助的“父母”研究将提供直接，实质性和长期的支持，并提供良好的组织我的提案的基础架构，这使得该K23应用程序非常时间和成本效益。这个奖项将使我能够获得与行为，社会心理和生物学评估有关的基本专业知识幼儿的OEB，小儿诊所样本的研究方法以及行为和干预 - 关于儿童对象的相关研究。我获得K23奖的培训目标是（1）获得经验和人类学科研究的研究设计和执行中的教学学习；（2）扩大我的知识和 OEB和营养评估的经验以及儿童肥胖的干预措施对于未来的项目；（3）在早期生活压力测量和压力管理策略中获得经验幼儿；（4）扩大我在先进人类基因组学方面的知识和分析技能；（5）专业人士发展; （6）赠款，为后续的r赠款做准备。在颁奖期结束时，我将准备启动独立的面向患者的研究职业，以进行观察和介入的研究以减少小儿肥胖的流行。