New approaches to target plaque inflammation in atherosclerosis

点击翻译按钮获取中文摘要

Atherosclerosis is the build-up of cholesterol plaques inside blood vessels that cause heart attacks. Macrophages are a type of cell that accumulate inside these plaques to make them grow. I am studying two different approaches to stop this build-up of cholesterol-rich macrophages in plaque to prevent heart attacks. One is the use of an anti-inflammatory, anti-gout drug called colchicine, and the other is to block a molecule called eukaryotic elongation factor 2 kinase (eEF2K).