The novel role of eukaryotic elongation factor 2 kinase (eEF2K) in atherosclerosis

真核延伸因子2激酶（eEF2K）在动脉粥样硬化中的新作用

• 批准号: nhmrc : 1142794
• 负责人: Dr Peter Psaltis
• 金额: $ 43.98万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-role-eukaryotic-eef2k-atherosclerosis/1319782
• 关键词: novel; role; eukaryotic; elongation; factor

Atherosclerosis causes build up of cholesterol plaques inside blood vessels that cause heart attacks and strokes. Macrophages are a type of cell that accumulate inside these plaques to make them grow. We work with a molecule called eukaryotic elongation factor 2 kinase (eEF2K), that controls how cells in the body divide and survive. We are studying how eEF2K controls the macrophage build up in plaque to develop new treatments against atherosclerosis that can stop heart attacks and strokes.

动脉粥样硬化导致胆固醇斑块在血管内积聚，从而导致心脏病发作和中风。巨噬细胞是一种细胞，积累在这些斑块内，使它们生长。我们使用一种称为真核细胞延伸因子2激酶（eEF2K）的分子，该分子控制体内细胞如何分裂和存活。我们正在研究eEF2K如何控制巨噬细胞在斑块中的积聚，以开发新的治疗动脉粥样硬化的方法，从而阻止心脏病发作和中风。