Training Program in Translational Brain Tumor Research

项目摘要 该计划的目标是为感兴趣的个人提供博士前和博士后培训， 从事转化性脑肿瘤研究。尽管神经外科医生和神经肿瘤学家尽了最大的努力， 和实验室的科学家，脑癌仍然是所有恶性肿瘤中最致命的。 脑癌治疗的改进进展缓慢，部分原因是个体相对缺乏。 培训的方式，使他们能够与临床医生和实验室为基础的研究人员进行沟通。这是 11-15年T32转化性脑肿瘤研究培训补助金的续期申请 加州大学旧金山分校弗朗西斯科。UCSF脑肿瘤中心是美国最大的项目， 专注于发展未来的转化型脑肿瘤研究者; 在临床和实验室世界之间无缝连接，这样做可以更有效地促进 开发新的脑肿瘤治疗干预措施。我们打算在培训成功的基础上 在前几个周期中，保持学员和导师的数量。此应用程序请求支持 博士后和博士前培训计划（3名博士后学员，1名博士前学员）。的 博士后培训生从学院的实验室和诊所中挑选，而predoc培训生则从 生物医学项目的顶尖学生该计划的教师由23名导师组成， 以及19个研究实验室的核心，他们的工作使UCSF脑肿瘤社区成为世界上最 生产力和世界公认的。在两年的支助请求过程中， 与这些实验室和诊所的PI合作，开发并完成有意义的重大翻译 脑肿瘤研究项目，并在此过程中成为流畅的实验室和临床研究 技术.基础科学培训生在临床神经病理学方面也有独特的、受监督的经验， 临床神经肿瘤学、临床试验设计和新的神经外科经验组成部分。与此同时 受训人员参加由教师主导的教学课程，该课程专门侧重于脑肿瘤相关问题， 让受训者发展一种共同的语言来讨论和理解脑肿瘤生物学， 诊断和治疗方式，以及该领域尚未解决的问题。附加课程和培训 活动，鼓励有效的口语和写作包括在内，有一个广泛的选择， 现有的课程，以帮助调整个别学员的教育经验。评价和辅导 还包括一些机制，以帮助确保该方案取得成功，并实现未来的职业目标。的 UCSF T32转化性脑肿瘤研究项目在吸引合格的 个人，并成功地准备研究人员领导翻译脑肿瘤研究团队 在国内和国际上，并加入对抗脑癌的斗争。

Project Summary The objective of this program is to provide predoctoral and postdoctoral training for individuals interested in careers in translational brain tumor research. Despite the best efforts of neurosurgeons, neuro-oncologists, and laboratory-based scientists, brain cancer remains among the most deadly of all malignancies. Improvements in brain cancer therapy have come slowly, in part because of the relative dearth of individuals trained in a manner that allows them to communicate with both clinicians and lab-based investigators. This is a renewal application for years 11-15 of the T32 Training Grant in Translational Brain Tumor Research at the University of California San Francisco. The UCSF Brain Tumor Center is the largest program in the nation that focuses on developing translational brain tumor investigators of the future; individuals who can move seamlessly between clinical and laboratory worlds and in doing so can more effectively contribute to the development of new therapeutic interventions for brain tumors. We intend to build upon the training successes in the previous cycles, maintaining the number of trainees and mentors. This application requests support for a postdoctoral and predoctoral Training Program (three postdoctoral trainees, 1 predoctoral trainees). The postdoctoral trainees are selected from the labs and clinics of the faculty, and the predoc trainee is drawn from the top-tier students in the Biomedical Sciences Program. The faculty of the Program consists of 23 mentors, and a core of 19 research labs whose work has made the UCSF brain tumor community one of the most productive and recognized in the world. Over the course of the two years of support requested, the trainees work with the PIs of these labs and clinics to develop and complete meaningful and significant translational brain tumor research projects, and in the process become fluent in laboratory-based and clinical research techniques. The basic science trainees also have unique, supervised experiences in clinical neuropathology, clinical neuro-oncology, clinical trial design and a new neurosurgery experience component. At the same time trainees take part in a faculty-led didactic curriculum uniquely focused on brain tumor-related issues and which allow trainees to develop a common language with which to discuss and understand brain tumor biology, diagnostic and therapeutic modalities, and unresolved problems in the field. Additional courses and training events that encourage effective speaking and writing are included, and there is an extensive selection of existing courses to help tailor the educational experience of individual trainees. Evaluation and mentoring mechanisms are included to help ensure success in the program and in attaining future career goals. The UCSF T32 Program in Translational Brain Tumor Research has a strong track record of attracting well-qualified individuals, and in successfully preparing investigators to lead translational brain tumor research teams nationally, and internationally, and joining in the fight against brain cancer.