A Portable PET Insert System for Simultaneous TOF-PET and MR Brain Imaging

用于同步 TOF-PET 和 MR 脑成像的便携式 PET 插入系统

• 批准号: 10007289
• 负责人: Chenming Chang
• 金额: $ 49.47万
• 依托单位: PETCOIL, INC.
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-07 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10007289
• 关键词: Address; Alzheimer' s Disease; Anatomy; Back; Brain; Brain Neoplasms; Brain imaging; Clinical; Coiled Bodies; Disease; Dose; Effectiveness; Electromagnetics; Electronics; Ensure; Epilepsy; Geometry; Goals; Grant; Head; Human; Hybrids; Image; Imaging technology; Lesion; MRI Scans; Magnetic Resonance Imaging; Malignant neoplasm of brain; Measures; Medical Imaging; Mental Depression; Mental disorders; Modification; Molecular; Neurologic; Noise; Organ; Patients; Performance; Phase; Photons; Pilot Projects; Positron-Emission Tomography; Radioactive; Research; Resolution; Risk; Scanning; Signal Transduction; Specific qualifier value; Structure; System; Techniques; Technology; Time; Translations; United States National Institutes of Health; Visualization; base; commercialization; cost; data acquisition; design; detector; imaging modality; imaging study; imaging system; innovation; manufacturability; meetings; nervous system disorder; novel; operation; portability; prototype; radio frequency; scale up; success

Project Summary Medical imaging technologies such as magnetic resonance imaging (MRI) and positron emission tomography (PET) have been widely used in studying the underlying mechanisms of mental illnesses and neurological disorders such as brain tumors, Alzheimer’s disease, epilepsy, and depression, etc. However, PET and MRI scans are almost always ordered as separate studies on separate machines, often resulting in weeks of delay in acquiring critical information about a patient’s disease. The recent rise of hybrid PET/MRI has enabled the simultaneous acquisition of anatomical, functional, and molecular information about the patient. However, its accessibility is limited by the high cost ($5M) of the commercial permanently integrated PET+MRI systems (+ an additional $1.5-2M room renovation cost). Today, only about 40 PET/MRI systems are installed in the US compared to almost 13,000 installed MRI systems. Moreover, the design and geometry of the commercial whole- body PET/CT and PET/MRI systems are not optimized for brain imaging, resulting in poorer sensitivity and spatial resolution achievable for neurological studies. To address these needs, PETcoil is proposing to develop a portable PET insert that can be installed into (and removed from) any existing MRI systems to achieve simultaneous PET/MRI for a fraction of the cost compared to installing an integrated PET+MR system. In addition to significantly lower cost, the proposed PET insert also provides 3 times higher photon sensitivity and 4 times finer volumetric spatial resolution compared to state-of-the-art whole-body integrated PET+MR systems. Key to facilitating this removable insert concept is the novel “radiofrequency (RF)-penetrable” technology we have developed at Stanford. In this Phase I project, we will create a compact and scalable design of the PET detector module ready for scaling up to a full RF-penetrable PET insert system for a Phase II proposal. We will also validate the MRI compatibility of the PET detector modules by comparing the PET and MRI performance results acquired with the PET detector modules outside the MRI system to those acquired inside 3 MRI systems under simultaneous PET and MRI operation. The success of this project will mitigate risks toward the commercialization of the first portable time-of-flight (TOF) RF-penetrable PET scanner insert that leverages existing MRI systems to achieve simultaneous TOF-PET/MR brain imaging, without requiring modifications to the MR system hardware. The proposed portable PET insert can greatly disseminate PET/MRI for brain imaging and facilitate the research and clinical characterization of a wide variety of neurological disorders.

项目摘要 磁共振成像（MRI）和正电子发射断层扫描等医学成像技术 (PET)已被广泛用于研究精神疾病和神经系统疾病的潜在机制， 例如脑肿瘤、阿尔茨海默病、癫痫和抑郁症等疾病。然而， 扫描几乎总是作为单独的研究在不同的机器上进行，通常会导致数周的延迟 获取病人疾病的关键信息最近兴起的混合PET/MRI使 同时获取关于患者的解剖、功能和分子信息。但其 可访问性受到商业永久集成PET+MRI系统（+一个）的高成本（500万美元）的限制， 额外的150万至200万美元的客房装修费用）。如今，美国仅安装了约40台PET/MRI系统 与近13，000台已安装的MRI系统相比。此外，商业整体的设计和几何形状- 身体PET/CT和PET/MRI系统未针对脑成像进行优化，导致灵敏度和空间分辨率较差。 神经学研究的分辨率。为了满足这些需求，PETcoil建议开发一种 便携式PET插入物，可以安装到任何现有的MRI系统中（和从任何现有的MRI系统中移除）， 与安装集成式PET+MR系统相比，同步PET/MRI的成本仅为一小部分。此外 为了显著降低成本，所提出的PET插入物还提供3倍的光子灵敏度和4倍的光子灵敏度。 与最先进的全身集成PET+MR系统相比，体积空间分辨率更高。关键 促进这种可拆卸插入物概念的是我们拥有的新颖的“射频（RF）穿透”技术， 是在斯坦福大学发展起来的。在这个第一阶段的项目中，我们将创建一个紧凑和可扩展的PET探测器设计 模块准备扩大到一个完整的RF穿透PET插入系统的第二阶段的建议。我们还将 通过比较PET和MRI性能结果，确认PET探测器模块的MRI兼容性 使用MRI系统外的PET探测器模块采集的数据与在3个MRI系统内采集的数据相比， 同时进行PET和MRI手术。该项目的成功将减轻商业化的风险 第一个便携式飞行时间（TOF）RF穿透PET扫描仪插件，利用现有的MRI系统 以实现同时TOF-PET/MR脑成像，而不需要修改MR系统硬件。 所提出的便携式PET插入物可以极大地传播PET/MRI用于脑成像，并促进研究 以及各种神经系统疾病的临床表征。