Core 3: Rexinoid Screening and Animal Core
Core 3: Rexinoid Screening and Animal Core
批准号:
10007604
负责人:
Mohammad Athar
金额:
$29.8万
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
已结题
起止时间:
2017-09-01 至 2022-08-31
关键词:
AnimalsApplications GrantsBasal cell carcinomaBindingBiological AvailabilityBreedingChemopreventionChemopreventive AgentChronicClinical TrialsCyclosporineDataDevelopmentDoseDrug KineticsEvaluationExposure toGenotypeGoalsHistologicHumanIACUCImmunocompetentImmunosuppressionIn VitroInbred HRS MiceLeadLipidsMalignant Epithelial CellMorbidity - disease rateMusOralOrganOrgan TransplantationPlayPredispositionPreventionProgram Research Project GrantsProtocols documentationRXRResearch PersonnelRoleSafetyScientistSerumServicesSkinSkin CancerSkin CarcinomaSkin NeoplasmsSquamous cell carcinomaStainsTestingTissuesToxic effectToxicologyTransplant RecipientsTriglyceridesUVB inducedUltraviolet Raysanimal breedinganimal dataanimal tissuebasecancer chemopreventionclinical applicationdesignexperimental studyimmunosuppressedin vivomortalitymouse modelnovelpre-clinicalpreclinical efficacypremalignantprogramsreceptorresponsescreeningskin cancer preventionskin lesiontooltumorigenesisultraviolet irradiation
中文摘要
Rexinoid筛选和动物核心(动物核心)是该计划的关键组成部分
格兰特计划它支持该计划的目标和目的,提供临床前
由项目2设计的新型rexinoids的疗效和安全性信息,
在器官移植中用作非黑素瘤皮肤癌的化学预防剂
受惠人士预防正常和非黑色素瘤皮肤癌的有效剂量50(ED 50)
将针对每种候选rexinoid建立环孢霉素处理的小鼠;我们的实验的ED 50将是100。
目前的铅化合物,UAB 30,将被用作比较。药代动力学,
新合成的类Rexinoids的耐受性、器官毒性和脂质异常也将被
测定Rexinoid筛选和动物中心提供的另一项服务是
维持Ptch+/-/SKH 1小鼠的群体。在长期暴露于紫外线辐射后,这些小鼠
发生基底细胞癌、鳞状细胞癌和癌前光化性角化病。
因此,他们仔细复制了人类皮肤癌对紫外线的敏感性。保持一种繁殖
这些独特的小鼠群体将是特别重要的实验中提出的
项目2和项目3。来自这些小鼠的组织也将被储存并可用于
对项目调查人员进行分析。核心科学家还将在开发方面提供帮助
实验协议,IACUC批准,并帮助紫外线照射,
免疫抑制方案。
英文摘要
The Rexinoid Screening and Animal Core (Animal Core) is a critical component of the Program
Project Grant. It supports the goals and objectives of the Program by providing pre-clinical
efficacy and safety information on novel rexinoids, designed by Project 2, that have the potential
to be useful as chemopreventive agents for non-melanoma skin cancers in organ transplant
recipients. Effective dose 50 (ED50) for prevention of non-melanoma skin cancer in normal and
cyclosporine-treated mice will be established for each candidate rexinoid; the ED50 of our
current lead compound, UAB30, which will be used as a comparator. Pharmacokinetics,
tolerability, organ toxicity and lipid abnormalities of the newly synthesized rexinoids will also be
determined. Another service provided by the Rexinoid Screening and Animal Core is to
maintain a colony of Ptch+/-/SKH1 mice. Following chronic exposure to UV radiation, these mice
develop basal cell carcinomas, squamous cell carcinomas and premalignant actinic keratoses.
Thus, they carefully replicate human skin cancer susceptibility to UV. Maintaining a breeding
colony of these unique mice will be particularly important for the experiments proposed in
Projects 2 and Project 3. Tissues from these mice will also be banked and made available for
analysis to Program investigators. Core scientists will also provide assistance in development
of experimental protocols, IACUC approvals, and help with UV irradiation and
immunosuppression protocols.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Optimization of Novel Molecular Target-based Drugs for Arsenical Skin Injury
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批准号:10259711
-
项目类别:
-
资助金额:$74.09万
-
财政年份:2020
-
负责人:Mohammad Athar
-
依托单位:
Optimization of Novel Molecular Target-based Drugs for Arsenical Skin Injury
-
批准号:10023318
-
项目类别:
-
资助金额:$74.1万
-
财政年份:2020
-
负责人:Mohammad Athar
-
依托单位:
Optimization of Novel Molecular Target-based Drugs for Arsenical Skin Injury
-
批准号:10700044
-
项目类别:
-
资助金额:$73.77万
-
财政年份:2020
-
负责人:Mohammad Athar
-
依托单位:
Optimization of Novel Molecular Target-based Drugs for Arsenical Skin Injury
-
批准号:10886403
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项目类别:
-
资助金额:$14.55万
-
财政年份:2020
-
负责人:Mohammad Athar
-
依托单位:
Core 4: Animal Breeding (UAB) and Exposure Core (MRIGLOBAL)
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批准号:10249112
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项目类别:
-
资助金额:$57.52万
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财政年份:2018
-
负责人:Mohammad Athar
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依托单位:
Project 1: Novel Pharmacological Inhibitors of Chemical Vesicants-mediated Cutaneous Injury
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批准号:10249113
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项目类别:
-
资助金额:$71.91万
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财政年份:2018
-
负责人:Mohammad Athar
-
依托单位:
UAB Research Center of Excellence in Arsenicals
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批准号:9767149
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项目类别:
-
资助金额:$376.02万
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财政年份:2018
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负责人:Mohammad Athar
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依托单位:
Administrative Core
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批准号:10249109
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项目类别:
-
资助金额:$36.57万
-
财政年份:2018
-
负责人:Mohammad Athar
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依托单位:
UAB Research Center of Excellence in Arsenicals
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批准号:10249107
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项目类别:
-
资助金额:$376.03万
-
财政年份:2018
-
负责人:Mohammad Athar
-
依托单位:
Core 3: Rexinoid Screening and Animal Core
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批准号:10263928
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项目类别:
-
资助金额:$18.62万
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财政年份:2017
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负责人:Mohammad Athar
-
依托单位:
Core 3: Rexinoid Screening and Animal Core
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批准号:10493962
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项目类别:
-
资助金额:$5.99万
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财政年份:2017
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负责人:Mohammad Athar
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依托单位:
Blocking Arsenicals-induced Cutaneous Injury
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批准号:9750839
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项目类别:
-
资助金额:$73.35万
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财政年份:2015
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负责人:Mohammad Athar
-
依托单位:
Blocking Arsenicals-induced Cutaneous Injury
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批准号:9318612
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项目类别:
-
资助金额:$73.35万
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财政年份:2015
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负责人:Mohammad Athar
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依托单位:
Blocking Arsenicals-induced Cutaneous Injury
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批准号:8928418
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项目类别:
-
资助金额:$73.35万
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财政年份:2015
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负责人:Mohammad Athar
-
依托单位:
Therapeutic Intervention of Lewisite-Mediated Cutaneous Blistering-Inflammation
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批准号:8927140
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项目类别:
-
资助金额:$7.35万
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财政年份:2014
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负责人:Mohammad Athar
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依托单位:
Therapeutic Intervention of Lewisite-Mediated Cutaneous Blistering-Inflammation
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批准号:8544981
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项目类别:
-
资助金额:$36.63万
-
财政年份:2012
-
负责人:Mohammad Athar
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依托单位:
Therapeutic Intervention of Lewisite-Mediated Cutaneous Blistering-Inflammation
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批准号:8414765
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项目类别:
-
资助金额:$36.63万
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财政年份:2012
-
负责人:Mohammad Athar
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依托单位:
Inhibiting Multiple Molecular Targets for Preventing Non-Melanoma Skin Cancer
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批准号:8448015
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项目类别:
-
资助金额:$28.57万
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财政年份:2011
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负责人:Mohammad Athar
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依托单位:
Inhibiting Multiple Molecular Targets for Preventing Non-Melanoma Skin Cancer
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批准号:8236878
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项目类别:
-
资助金额:$30.4万
-
财政年份:2011
-
负责人:Mohammad Athar
-
依托单位:
Inhibiting Multiple Molecular Targets for Preventing Non-Melanoma Skin Cancer
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批准号:8619513
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项目类别:
-
资助金额:$29.49万
-
财政年份:2011
-
负责人:Mohammad Athar
-
依托单位: