An exercise intervention to Reduce Neuropathic Pain and Brain Inflammation after Spinal Cord Injury
减少脊髓损伤后神经性疼痛和脑炎症的运动干预
基本信息
- 批准号:10005403
- 负责人:
- 金额:$ 84.39万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-01 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:Absence of pain sensationAcuteAerobicAerobic ExerciseAffectAnalgesicsAnimal ModelAnimalsAnti-Inflammatory AgentsAtrophicBindingBrainC-reactive proteinCardiacCardiac OutputCardiovascular DiseasesCardiovascular PhysiologyCardiovascular systemCause of DeathCell ProliferationCervical spinal cord structureChronicClinical TrialsContractsCouplesDataDiseaseEarly InterventionElectric StimulationEncephalitisEndocrineExerciseFatty acid glycerol estersFutureGeneral PopulationHealth BenefitHeartHeart DiseasesHippocampus (Brain)HumanImpairmentIndividualInflammationInflammatory ResponseInjuryInsulin ResistanceInterleukin-6Ischemic StrokeLegLesionLinkLungLung CapacityLymphoidMagnetic Resonance ImagingMeasuresMental DepressionMetabolicMicrogliaModelingMoodsMorbidity - disease rateMusMuscleMuscular AtrophyNerve DegenerationNervous System TraumaNeuraxisOpioidOpioid ReceptorOpioid Receptor BindingOutcome MeasureOxygenPainPain interferenceParalysedPathway interactionsPatientsPersistent painPhenotypePhysical activityPhysiologicalPopulationPositron-Emission TomographyPrevalenceQuality of lifeRandomizedRehabilitation therapyReportingRestRiskSpinal cord injurySpinal cord injury patientsSpinal nerve structureStrokeStructureSymptomsSystemTrainingTranslatingTraumatic Brain InjuryValidationVolitionWaiting ListsWorkarmbench to bedsidebeta-Endorphinbody systemcardiovascular risk factorchronic neuropathic painchronic painconditioned pain modulationcostendogenous opioidsexercise capacityexercise intensityexercise interventionfunctional electrical stimulationglial activationgray matterheart disease riskhemodynamicsimprovedimproved outcomemacrophagemidbrain central gray substancemortalitymuscle formnerve supplyneurogenesisneuroinflammationneurorestorationnewsopioid usepain modelpain reductionpainful neuropathyphysical inactivitypost strokepre-clinicalprimary outcomeresponsesecondary outcometransmission process
项目摘要
Spinal Cord Injury (SCI) leads to alterations in brain structure and function by spinal nerve
damage, secondary inflammatory responses, and by the consequences of living with paralysis
and neuropathic pain. Physical inactivity due to lower body paralysis rapidly leads to loss of
muscle, and risk of heart disease. The leading cause of death after a spinal cord injury is
cardiovascular disease, and just a year after injury, those with SCI have a peak exercise
capacity half that of the unfit general population.
The good news is that aerobic exercise reduces the risk of chronic metabolic and
cardiorespiratory diseases, reduces inflammation and pain, and increases mood and quality of
life. Exercise can also reduce brain inflammation, enhance endogenous analgesia, and
increases the size of the hippocampus.
The issue is that muscle paralysis in SCI restricts the ability to achieve the levels of exercise
that is necessary for broad analgesic, anti-inflammatory and neuroprotective benefits. Arm
exercise can have some effects on heart and lung capacity, but the small muscle mass is
insufficient to produce more than modest aerobic work. With functional electrical stimulation
(FES), leg muscles that are paralyzed can be made to contract, thereby allowing more of the
body to be exercised. The full rowing stroke is produced by both the (stimulated) legs and arms,
increasing the active muscle mass and resulting in an aerobic work-out that is intensive enough
to improve heart, lung, and – maybe – brain function.
In this clinical trial of sub-acute spinal cord injured subjects, we will study how 12 weeks of FES-
RT, in comparisons to 12 weeks of wait-list, changes pain, brain structure, endogenous opioid
function and brain inflammation.
We will measure changes using positron emission tomography and magnetic resonance
imaging We hypothesize a decrease in pain interference, an increase in hippocampal volume,
increased endogenous opioid transmission in the periaqueductal gray, and decreased
hippocampus neuroinflammation.
脊髓损伤(SCI)通过脊髓神经引起脑结构和功能的改变
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Clas Linnman其他文献
Clas Linnman的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Clas Linnman', 18)}}的其他基金
An exercise intervention to Reduce Neuropathic Pain and Brain Inflammation after Spinal Cord Injury
减少脊髓损伤后神经性疼痛和脑炎症的运动干预
- 批准号:
10468722 - 财政年份:2019
- 资助金额:
$ 84.39万 - 项目类别:
An exercise intervention to Reduce Neuropathic Pain and Brain Inflammation after Spinal Cord Injury
减少脊髓损伤后神经性疼痛和脑炎症的运动干预
- 批准号:
10237234 - 财政年份:2019
- 资助金额:
$ 84.39万 - 项目类别:
相似海外基金
The effects of acute aerobic exercise on hippocampal function and microstructure in older adults
急性有氧运动对老年人海马功能及微结构的影响
- 批准号:
10548811 - 财政年份:2022
- 资助金额:
$ 84.39万 - 项目类别:
The effects of acute aerobic exercise on hippocampal function and microstructure in older adults
急性有氧运动对老年人海马功能及微结构的影响
- 批准号:
10314779 - 财政年份:2022
- 资助金额:
$ 84.39万 - 项目类别:
The effects of acute aerobic exercise on hippocampal function and microstructure in older adults
急性有氧运动对老年人海马功能及微结构的影响
- 批准号:
10580466 - 财政年份:2022
- 资助金额:
$ 84.39万 - 项目类别:
The Effects of Blood Flow Restriction During Acute Aerobic Exercise on Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha (PGC-1a) Expression
急性有氧运动期间血流限制对过氧化物酶体增殖物激活受体γ共激活物1-α(PGC-1a)表达的影响
- 批准号:
529237-2018 - 财政年份:2018
- 资助金额:
$ 84.39万 - 项目类别:
Alexander Graham Bell Canada Graduate Scholarships - Master's
The Influence of Acute Bouts of Aerobic Exercise on Neuroplasticity and Motor Learning after Stroke
急性有氧运动对中风后神经可塑性和运动学习的影响
- 批准号:
343900 - 财政年份:2016
- 资助金额:
$ 84.39万 - 项目类别:
Operating Grants
The potentiation of neurovascular coupling in cognitive-brain areas following acute aerobic exercise
急性有氧运动后认知脑区域神经血管耦合的增强
- 批准号:
460143-2014 - 财政年份:2016
- 资助金额:
$ 84.39万 - 项目类别:
Postgraduate Scholarships - Doctoral
The effects of acute aerobic exercise on memory function
急性有氧运动对记忆功能的影响
- 批准号:
15K12687 - 财政年份:2015
- 资助金额:
$ 84.39万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
The potentiation of neurovascular coupling in cognitive-brain areas following acute aerobic exercise
急性有氧运动后认知脑区域神经血管耦合的增强
- 批准号:
460143-2014 - 财政年份:2015
- 资助金额:
$ 84.39万 - 项目类别:
Postgraduate Scholarships - Doctoral
Potential for gene expression by acute aerobic exercise with locally force of muscle
局部肌肉力量急性有氧运动的基因表达潜力
- 批准号:
26750317 - 财政年份:2014
- 资助金额:
$ 84.39万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
The potentiation of neurovascular coupling in cognitive-brain areas following acute aerobic exercise
急性有氧运动后认知脑区域神经血管耦合的增强
- 批准号:
460143-2014 - 财政年份:2014
- 资助金额:
$ 84.39万 - 项目类别:
Postgraduate Scholarships - Doctoral