Realistic Measurements of tDCS-Modulated Activity and Electric Fields in the Human Brain In Vivo

体内人脑 tDCS 调制活动和电场的真实测量

• 批准号: 10005411
• 负责人: Pratik Yashvant Chhatbar
• 金额: $ 15.77万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10005411
• 关键词: Algorithms; Anatomy; Area; Behavioral; Brain; Centers of Research Excellence; Characteristics; Clinical; Computer software; Data; Data Set; Defect; Detection; Disease; Dose; Electrocorticogram; Electroencephalography; Elements; Ensure; Epilepsy; Feedback; Foundations; Funding; Future; Goals; Grant; Hospitals; Human; Image; Individual; Infrastructure; Intractable Epilepsy; Magnetic Resonance Imaging; Measurement; Mental Depression; Methods; Modality; Modeling; Modification; Motor; Motor Evoked Potentials; Outcome; Patient Recruitments; Patients; Physiological; Population; Procedures; Process; Protocols documentation; Recovery; Rehabilitation therapy; Resolution; Scalp structure; Signal Transduction; Solid; Spinal cord injury; Stroke; Structure; System; Techniques; Testing; Time; Training; Transcranial magnetic stimulation; base; behavioral outcome; brain abnormalities; clinical care; dosage; dose individualization; electric field; implantation; improved; improved outcome; in vivo; inter-individual variation; models and simulation; multidisciplinary; multimodality; neurophysiology; neuropsychiatry; neuroregulation; novel; patient safety; recruit; rehabilitation strategy; relating to nervous system; response; source localization; spatiotemporal; stroke recovery; success

This project focuses on a neuroengineering approach to improve rehabilitative strategies involving non-invasive brain stimulation (NIBS) technique called transcranial direct current stimulation (tDCS). tDCS is being investigated heavily in recovery from a variety of neuropsychiatric conditions, including depression and stroke. However, tDCS does not show consistent efficacy across subjects, which can be attributed to inter-individual variability resulting from different strength of electric fields (EF) and resultant changes in neural activity. Such variability in recovery can be decreased if tDCS therapy dose is titrated based on tDCS-generated EF and tDCS- modulated neural activity. Non-invasive methods like scalp electroencephalography (EEG) are convenient to use without involving invasive intracranial recording procedures, e.g., electrocorticography (ECoG) and/or stereoencephalography (SEEG). However, the spatiotemporal resolution of EEG is suboptimal when compared with ECoG/SEEG, probably because of volume conduction. Therefore, a transfer function that can achieve ECoG/SEEG-level precision using EEG recordings is desirable. To that end, this project will establish a framework of simultaneous recording of EEG, ECoG and/or SEEG along with tDCS application. Such a framework will yield a transfer function that may be very useful to investigate tDCS dose-individualization based on neural activity using non-invasive methods (e.g., EEG). Such an approach may be more reliable when compared to a simulation model-based approach. Subjects with refractory epilepsy undergoing ECoG/SEEG implantation serve as a natural model to investigate the real-time reactivity of neural system in response to tDCS. The two overlapping areas to be investigated in this project are: 1. Can EEG-based extrapolations of tDCS-generated EF achieve accuracy comparable to ECoG/SEEG- based extrapolations? ECoG/SEEG have superior spatiotemporal resolution compared to EEG, but are invasive and therefore not practical in stroke subjects. Through analyzing simultaneous recording of both EEG and ECoG/SEEG in subjects, new algorithms will be developed to extrapolate tDCS-generated EF using EEG that can match the accuracy of ECoG/SEEG extrapolations. 2. How tightly correlated are scalp EEG and invasive ECoG/SEEG before/during/after tDCS application? The first step towards understanding direct interaction of tDCS with neural activity is simultaneous administration of tDCS and recording neural activity at various depths. Specialized recording setup is required to achieve this and we plan to use clinical setup with some modifications, ensuring patient safety. Specialized software is required to process the data towards accurate source localization of neural activity during tDCS administration, and to compare EEG-based source localization with the ECoG/SEEG-based. In the long term, our multidisciplinary team is confident to deliver a novel, non-invasive neural feedback-based, neuromodulatory approach to tDCS dose-individualization towards efficacious recovery outcomes.

该项目的重点是神经工程的方法，以改善康复策略，包括非侵入性 脑刺激（NIBS）技术称为经颅直流电刺激（tDCS）。tDCS正在 在从各种神经精神疾病（包括抑郁症和中风）中恢复时进行了大量研究。 然而，tDCS在受试者中未显示一致的疗效，这可归因于个体间差异。 由不同电场强度（EF）引起的变异性以及由此引起的神经活动的变化。等 如果根据tDCS产生的EF和tDCS滴定tDCS治疗剂量，则可降低恢复的变异性。 调节神经活动头皮脑电图（EEG）等非侵入性方法使用方便 而不涉及侵入性颅内记录过程，例如，皮质电图（ECoG）和/或 脑立体图（SEEG）。然而，EEG的时空分辨率是次优的， ECoG/SEEG，可能是因为容量传导。因此，可以实现的传递函数 使用EEG记录的ECoG/SEEG级精度是期望的。为此，该项目将建立一个 同时记录EEG、ECoG和/或SEEG沿着tDCS应用的框架。这样的 框架将产生一个传递函数，这可能是非常有用的研究tDCS剂量个性化的基础上， 使用非侵入性方法（例如，EEG）。这种方法可能更可靠， 与基于模拟模型的方法相比。接受ECoG/SEEG的难治性癫痫受试者 植入作为研究神经系统对tDCS响应的实时反应性的自然模型。 本项目将调查的两个重叠领域是： 1.基于EEG的tDCS产生的EF外推是否能达到与ECoG/SEEG相当的准确性- 基于外推？与EEG相比，ECoG/SEEG具有上级时空分辨率，但 侵入性的，因此在中风受试者中不实用。通过分析同时记录的两个EEG 和受试者的ECoG/SEEG，将开发新的算法来使用EEG外推tDCS产生的EF 可以匹配ECoG/SEEG外推的准确性。 2.在tDCS应用之前/期间/之后，头皮EEG和侵入性ECoG/SEEG的相关性如何？ 理解tDCS与神经活动直接相互作用的第一步是同时给药 记录不同深度的神经活动。需要专门的记录设置来实现这一点 我们计划使用经过一些修改的临床设置，以确保患者安全。专业软件是 需要处理数据以在tDCS施用期间实现神经活动的准确源定位， 并将基于EEG的源定位与基于ECoG/SEEG的源定位进行比较。 从长远来看，我们的多学科团队有信心提供一种新的，非侵入性的神经反馈为基础的， tDCS剂量个体化的神经调节方法，以实现有效的恢复结果。