The impact of dietary zinc deficiency on innate immunity to lung infection
膳食缺锌对肺部感染先天免疫力的影响
基本信息
- 批准号:10005451
- 负责人:
- 金额:$ 12.44万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-01 至 2021-01-31
- 项目状态:已结题
- 来源:
- 关键词:Academic Medical CentersAcinetobacter baumanniiAffectAnabolismAnimal ModelAnimalsAnthelminticsAntibacterial ResponseBacteriaBiologicalBiologyCell MaintenanceCessation of lifeChildCytokine SignalingDataDefectDietDietary ZincDoctor of PhilosophyEngineeringEnsureEnvironmental Risk FactorEpithelialEpithelial CellsEpitheliumFacultyFlow CytometryGenetic EngineeringGerm CellsGoalsHIVHealthHumanImageImmuneImmune System DiseasesImmunityImmunologyIncidenceInfectionInflammationInflammatoryInflammatory ResponseInjuryInnate Immune ResponseInstitutionInterleukin-13InvadedLaboratoriesLeukocytesLifeLinkLower Respiratory Tract InfectionLungLung infectionsLymphopoiesisMeasuresMediatingMentorsMetabolismMetalsMicrobiologyModelingMolecularMucosal ImmunityMulti-Drug ResistanceMusNatural ImmunityNutrientObservational StudyOpportunistic InfectionsOutcomePathogenesisPathogenicityPatientsPersonsPhagocytosisPhasePhenotypePneumoniaPopulationPositioning AttributePredispositionProductionRegulationResearchResolutionRiskRoleSalmonella entericaSignal TransductionSourceStructure of respiratory epitheliumTestingThiamineTimeTrainingTraining ActivityUniversitiesWisconsinWorkWorld Health OrganizationZincZinc deficiencyZinc supplementationairway epitheliumbacterial geneticsbronchial epitheliumcareercareer developmentcell typecytokineexperimental studyhigh riskhuman pathogenimmune functionin vivoinnate immune functioninnate immune mechanismsinnovationinsightmacrophagemembermortalitymouse modelmulti-drug resistant pathogenneutrophilnovelnutritionpathogenpathogenic bacteriapreventrandomized controlled studyresponsetenure tracktherapeutic targetventilator-associated pneumonia
项目摘要
PROJECT SUMMARY
Candidate: My postdoctoral research thus far focused on the effects of host dietary zinc on bacterial
pathogenesis during Acinetobacter baumannii pneumonia in Dr. Eric P. Skaar's laboratory at Vanderbilt
University Medical Center. I earned my PhD in Microbiology with Dr. Diana Downs studying thiamine (vitamin
B1) biosynthesis in Salmonella enterica at the University of Wisconsin-Madison and the University of Georgia.
Career Goals and Objectives: My career goal is to be a tenure-track faculty member at a top-tier research
institution working with trainees at all levels to understand how metabolism affects the host-pathogen interface.
In order to achieve this goal, I need additional mentored training in host inflammation and immunology.
Career Development and Training Activities: My mentoring committee will be led by Dr. Skaar and
include Dr. R. Stokes Peebles, Dr. C. Henrique Serezani, and Dr. Dawn C. Newcomb, experts in metals at the
host-pathogen interface, infection imaging, type 2 lung immunity, innate inflammation, and respiratory epithelial
biology. My mentoring committee will continue to meet biannually and support my practical, didactic, and
career development training to aid my transition to independence.
Research Strategy: The World Health Organization estimated that zinc deficiency contributes to 16% of
lower respiratory infections globally. Our exciting preliminary data show that zinc deficiency significantly
increases mortality from A. baumannii pneumonia by 24 h post infection, and that neutralization of the type 2
cytokine IL-13 protects mice from mortality. The central hypothesis of this proposal is that dietary Zn
deficiency promotes type 2 inflammation during lung infection, preventing A. baumannii killing.
Significance and Innovation: The research plan will identify molecular mechanisms underlying the link
between zinc deficiency and pneumonia. The proposed experiments will uncover potential therapeutic targets
to promote lung innate immunity.
Aim 1 (K99): Determine the effect of Zn deficiency on leukocyte-mediated bacterial killing. We will
test the effect of zinc deficiency on leukocyte function ex vivo and in vivo using sophisticated animal models
and an engineered suite of fluorescent A. baumannii to image the host-pathogen interface in real time.
Aim 2 (R00): Identify the mechanism by which Zn deficiency promotes type 2 immunity in response
to bacterial lung infection. We will identify the cellular source of IL-13 and upstream cytokine signaling by the
airway epithelium to investigate the effect of Zn deficiency on human airway epithelial cell initial inflammatory
response to infection that drives lung mucosal immunity.
Transition to independence: These aims were developed independently of Dr. Skaar and my co-mentors,
and they will not pursue overlapping research plans. During the K99, I will apply for faculty positions nationally.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Lauren Disterhoft Palmer其他文献
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{{ truncateString('Lauren Disterhoft Palmer', 18)}}的其他基金
The impact of dietary zinc deficiency on innate immunity to lung infection
膳食缺锌对肺部感染先天免疫力的影响
- 批准号:
10327646 - 财政年份:2021
- 资助金额:
$ 12.44万 - 项目类别:
The impact of dietary zinc deficiency on innate immunity to lung infection
膳食缺锌对肺部感染先天免疫力的影响
- 批准号:
10764457 - 财政年份:2021
- 资助金额:
$ 12.44万 - 项目类别:
The impact of dietary zinc deficiency on innate immunity to lung infection
膳食缺锌对肺部感染先天免疫力的影响
- 批准号:
10557920 - 财政年份:2021
- 资助金额:
$ 12.44万 - 项目类别:
The impact of dietary zinc deficiency on innate immunity to lung infection
膳食缺锌对肺部感染先天免疫力的影响
- 批准号:
10294382 - 财政年份:2021
- 资助金额:
$ 12.44万 - 项目类别:
The impact of dietary zinc deficiency on innate immunity to lung infection
膳食缺锌对肺部感染先天免疫力的影响
- 批准号:
10478314 - 财政年份:2021
- 资助金额:
$ 12.44万 - 项目类别:
The impact of dietary zinc deficiency on innate immunity to lung infection
膳食缺锌对肺部感染先天免疫力的影响
- 批准号:
10836257 - 财政年份:2021
- 资助金额:
$ 12.44万 - 项目类别:
Defining the molecular link between zinc deficiency and pneumonia
定义缺锌与肺炎之间的分子联系
- 批准号:
9269054 - 财政年份:2016
- 资助金额:
$ 12.44万 - 项目类别:
Defining the molecular link between zinc deficiency and pneumonia
定义缺锌与肺炎之间的分子联系
- 批准号:
9405713 - 财政年份:2016
- 资助金额:
$ 12.44万 - 项目类别:
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