The impact of dietary zinc deficiency on innate immunity to lung infection

膳食缺锌对肺部感染先天免疫力的影响

基本信息

项目摘要

PROJECT SUMMARY Candidate: My postdoctoral research thus far focused on the effects of host dietary zinc on bacterial pathogenesis during Acinetobacter baumannii pneumonia in Dr. Eric P. Skaar's laboratory at Vanderbilt University Medical Center. I earned my PhD in Microbiology with Dr. Diana Downs studying thiamine (vitamin B1) biosynthesis in Salmonella enterica at the University of Wisconsin-Madison and the University of Georgia. Career Goals and Objectives: My career goal is to be a tenure-track faculty member at a top-tier research institution working with trainees at all levels to understand how metabolism affects the host-pathogen interface. In order to achieve this goal, I need additional mentored training in host inflammation and immunology. Career Development and Training Activities: My mentoring committee will be led by Dr. Skaar and include Dr. R. Stokes Peebles, Dr. C. Henrique Serezani, and Dr. Dawn C. Newcomb, experts in metals at the host-pathogen interface, infection imaging, type 2 lung immunity, innate inflammation, and respiratory epithelial biology. My mentoring committee will continue to meet biannually and support my practical, didactic, and career development training to aid my transition to independence. Research Strategy: The World Health Organization estimated that zinc deficiency contributes to 16% of lower respiratory infections globally. Our exciting preliminary data show that zinc deficiency significantly increases mortality from A. baumannii pneumonia by 24 h post infection, and that neutralization of the type 2 cytokine IL-13 protects mice from mortality. The central hypothesis of this proposal is that dietary Zn deficiency promotes type 2 inflammation during lung infection, preventing A. baumannii killing. Significance and Innovation: The research plan will identify molecular mechanisms underlying the link between zinc deficiency and pneumonia. The proposed experiments will uncover potential therapeutic targets to promote lung innate immunity. Aim 1 (K99): Determine the effect of Zn deficiency on leukocyte-mediated bacterial killing. We will test the effect of zinc deficiency on leukocyte function ex vivo and in vivo using sophisticated animal models and an engineered suite of fluorescent A. baumannii to image the host-pathogen interface in real time. Aim 2 (R00): Identify the mechanism by which Zn deficiency promotes type 2 immunity in response to bacterial lung infection. We will identify the cellular source of IL-13 and upstream cytokine signaling by the airway epithelium to investigate the effect of Zn deficiency on human airway epithelial cell initial inflammatory response to infection that drives lung mucosal immunity. Transition to independence: These aims were developed independently of Dr. Skaar and my co-mentors, and they will not pursue overlapping research plans. During the K99, I will apply for faculty positions nationally.
项目总结

项目成果

期刊论文数量(0)
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Lauren Disterhoft Palmer其他文献

Lauren Disterhoft Palmer的其他文献

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{{ truncateString('Lauren Disterhoft Palmer', 18)}}的其他基金

The impact of dietary zinc deficiency on innate immunity to lung infection
膳食缺锌对肺部感染先天免疫力的影响
  • 批准号:
    10327646
  • 财政年份:
    2021
  • 资助金额:
    $ 12.44万
  • 项目类别:
The impact of dietary zinc deficiency on innate immunity to lung infection
膳食缺锌对肺部感染先天免疫力的影响
  • 批准号:
    10764457
  • 财政年份:
    2021
  • 资助金额:
    $ 12.44万
  • 项目类别:
The impact of dietary zinc deficiency on innate immunity to lung infection
膳食缺锌对肺部感染先天免疫力的影响
  • 批准号:
    10557920
  • 财政年份:
    2021
  • 资助金额:
    $ 12.44万
  • 项目类别:
The impact of dietary zinc deficiency on innate immunity to lung infection
膳食缺锌对肺部感染先天免疫力的影响
  • 批准号:
    10294382
  • 财政年份:
    2021
  • 资助金额:
    $ 12.44万
  • 项目类别:
The impact of dietary zinc deficiency on innate immunity to lung infection
膳食缺锌对肺部感染先天免疫力的影响
  • 批准号:
    10478314
  • 财政年份:
    2021
  • 资助金额:
    $ 12.44万
  • 项目类别:
The impact of dietary zinc deficiency on innate immunity to lung infection
膳食缺锌对肺部感染先天免疫力的影响
  • 批准号:
    10836257
  • 财政年份:
    2021
  • 资助金额:
    $ 12.44万
  • 项目类别:
Defining the molecular link between zinc deficiency and pneumonia
定义缺锌与肺炎之间的分子联系
  • 批准号:
    9269054
  • 财政年份:
    2016
  • 资助金额:
    $ 12.44万
  • 项目类别:
Defining the molecular link between zinc deficiency and pneumonia
定义缺锌与肺炎之间的分子联系
  • 批准号:
    9405713
  • 财政年份:
    2016
  • 资助金额:
    $ 12.44万
  • 项目类别:

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用于治疗或预防抗生素耐药鲍曼不动杆菌感染的单克隆抗体的分离和表征
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定义鲍曼不动杆菌感染期间宿主-病原体界面的关键参与者
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    488684
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    2023
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    Grant-in-Aid for Early-Career Scientists
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仿生巨噬细胞膜包被的纳米海绵:一种治疗多重耐药铜绿假单胞菌和鲍曼不动杆菌医院相关肺炎的新疗法
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利用菌株历史改进对鲍曼不动杆菌抗菌药物耐药性演变的预测
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鉴定鲍曼不动杆菌的生态位特异性适应
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