Development of a Just-in-Time Adaptive Intervention to Reduce High-Intensity Drinking among Young Adults

项目总结/摘要 高强度饮酒（HID;女性/男性8+/10+饮酒）是过度饮酒的一种独特形式， 导致严重的，甚至危及生命的身体和心理后果。15%的年轻人 在过去的两周里，成年人参与了HID，这种形式的饮酒最常发生在社交场合。 设置.饮酒环境的特征（例如，酒精供应、事件的人口统计学组成） 与酒精消费水平有关;然而，目前对年轻成人酒精的干预措施 滥用不能解决饮酒环境中的实时风险因素。拟议的指导研究 科学家职业发展奖（K 01）将为考克斯博士提供培训和指导， 一位独立的行为科学家专注于预防年轻人滥用酒精。的目的 拟议的研究是确定年轻人中HID的直接饮酒环境中的风险因素， 利用这些信息开发和试点测试一个及时的适应性干预（JITAI），解决 确定风险因素，以减少HID和相关后果。为了实现她的长期职业目标，博士。 考克斯需要额外的训练。该K 01将为考克斯博士提供必要的支持，以进行以下工作 科学培训目标：（1）获得设计移动健康干预方法的技能，（2）执行 实验设计，以测试干预年轻成人酒精滥用，（3）获得熟练的优先权 为干预战略选择行为改变技术，以及（4）丰富统计能力， 分析密集的纵向数据。这些目标将通过一项全面的培训计划来实现， 包括一对一会议，教学/培训，导师指导阅读，研讨会/实验室会议， 科学会议和实践研究经验。为了支持这些目标，考克斯博士有一个指导小组 由所有这些领域的领先研究人员组成，每个人都有成功的NIH资助的记录。 研究和丰富的指导经验。通过培训计划获得的技能将付诸行动 通过执行补充研究计划。目标1是确定JITAI决策点， 通过一项为期4周的研究，确定饮酒环境中与HID唯一相关的因素， 对50名年轻人（18-24岁）进行的生态学瞬时评估。目标2是迭代开发JITAI 解决已确定的风险因素，以防止这一人群中的HID。目标3是对吉泰进行试点测试，以a） 评估其可行性和可接受性，以及B）探索对HID的初步影响。这项研究与 与NIAAA的倡议，以制定有效的预防战略，解决风险的后果， 过量饮酒或其他形式的酒精滥用。这项研究将为Dr. 考克斯的第一个R 01提案，将在本拟议奖项的最后一年提交。

PROJECT SUMMARY/ABSTRACT High-intensity drinking (HID; 8+/10+ drinks for females/males) is a distinct form of excessive alcohol use that results in significant, even life-threatening, physical and psychological consequences. Fifteen percent of young adults have engaged in HID in the past two weeks, and this form of drinking most often occurs in social settings. Characteristics of the drinking context (e.g. alcohol availability, demographic composition of the event) are associated with levels of alcohol consumption; however, current interventions for young adult alcohol misuse do not address real-time risk factors in the drinking context. The proposed Mentored Research Scientist Career Development Award (K01) will provide Dr. Cox with the training and mentorship to become an independent behavioral scientist focused on the prevention of young adult alcohol misuse. The objective of the proposed research is to identify risk factors in the immediate drinking context for HID among young adults and use this information to develop and pilot test a just-in-time adaptive intervention (JITAI) that addresses the identified risk factors to reduce HID and associated consequences. To achieve her long-term career goals, Dr. Cox requires additional training. This K01 will provide the necessary support for Dr. Cox to pursue the following scientific training objectives: (1) obtain skills in the design of mHealth intervention approaches, (2) execute experimental designs to test interventions for young adult alcohol misuse, (3) gain proficiency in priority selection of behavior change techniques for intervention strategies, and (4) enrich statistical capacities in the analysis of intensive longitudinal data. These objectives will be met through a comprehensive training plan that consists of one-on-one meetings, didactics/trainings, mentor-directed readings, seminars/lab meetings, scientific meetings, and hands-on research experience. To support these goals, Dr. Cox has a mentoring team comprised of leading researchers in all of these areas that each have a record of successful NIH-funded research and extensive mentoring experience. Skills gained through the training plan will be put into action through the execution of the complementary research plan. Aim 1 is to determine JITAI decision points by identifying factors in the drinking context that are uniquely associated with HID via a 4-week study using ecological momentary assessment with 50 young adults (ages 18-24). Aim 2 is to iteratively develop a JITAI that addresses identified risk factors to prevent HID among this population. Aim 3 is to pilot test the JITAI to a) assess its feasibility and acceptability, and b) explore preliminary effects on HID. This research is consistent with NIAAA’s initiative to develop effective prevention strategies that address the risks for consequences that result from excessive drinking or other forms of alcohol misuse. The proposed study will provide data for Dr. Cox’s first R01 proposal, to be submitted in the final year of this proposed award.