Preventing alcohol misuse and consequences in vulnerable women

项目摘要 这项以患者为导向的导师研究职业发展奖(K23)将为Alyssa Norris博士提供 培训和研究活动需要成为一名独立调查员，重点是 针对年轻女性酗酒的创新预防方法的开发和评估 使用，特别侧重于性少数群体。性少数群体女性明显表现出 增加危险饮酒和饮酒后果的风险。尽管有越来越多的证据表明这些 尽管存在酒精使用方面的差距，但对于性少数群体妇女来说，没有经过检验的预防方法。这是 鉴于性少数族裔妇女表现出独特的饮酒危险因素，并报告了 对目前的待遇以及为其他少数群体量身定制的文化方案的不满 是有效的。指导和培训团队包括以下领域的专家心理学家 研究：对年轻女性和弱势人群中酒精滥用的简短干预(M.Carey；K. 指导干预发展的定性方法(格思里)；纵向数据分析 指导干预内容的临床试验和潜在分析(Dunsiger)；以及性行为中的酒精滥用 少数民族妇女(刘易斯)。此外，我将继续担任精神病学和人类科学的助理教授 布朗大学的行为(DPHB)和行为与预防中心的研究科学家 米里亚姆医院的医学(CBPM)。DPHB和CBPM致力于支持来自 完成他们的培训奖励活动，以过渡到独立的NIH资金。DPHB目前 有200多项正在进行的研究和5000万美元的外部赞助研究，并致力于支持 早期教师向独立过渡。诺里斯博士将应用通过提议的 开展培训活动，制定理论健全和循证的预防方案，以 减少性少数群体女性的酒精滥用。具体地说，诺里斯博士将开发一种预防 通过以下三个目标减少酗酒方案：(1)形成性需求评估：(1)系统化 回顾性少数族裔女性饮酒的理论模型，以及(1b)深入访谈(N=20)至 通过参与性参与指导干预措施的发展；(2)完善治疗材料和 分娩：(2)次级数据分析，以确定对性少数群体妇女有意义的规范性反馈 (Kaysen)，和(2b)认知访谈(N=10)，以指导干预的发展 参与性参与；(3)先导性随机对照试验(N=70)，比较干预和 注意力匹配对照组，以确定干预的可行性和可接受性，并使用 将重点放在初步疗效上，以指导未来的赠款提案。

PROJECT ABSTRACT This Mentored Patient-Oriented Research Career Development Award (K23) will provide Dr. Alyssa Norris with the training and research activities needed to become an independent investigator focusing on the development and evaluation of innovative prevention approaches targeting young women’s alcohol use, with a specialized focus in sexual minority populations. Sexual minority women display markedly increased risk for hazardous alcohol use and alcohol consequences. Despite mounting evidence of these alcohol use disparities, there are no tested prevention approaches for sexual minority women. This is unwarranted given that sexual minority women evince unique risk factors for alcohol use and report dissatisfaction with current treatments, as well as that culturally-tailored programming for other minority groups is efficacious. The mentorship and training team includes expert psychologists in the following areas of research: brief interventions for alcohol misuse among young women and vulnerable populations (M. Carey; K. Carey); qualitative methodology to guide intervention development (Guthrie); longitudinal data analyses for clinical trials and latent analysis to guide intervention content (Dunsiger); and alcohol misuse among sexual minority women (Lewis). Further, I will continue to work as an Assistant Professor of Psychiatry and Human Behavior (DPHB) at Brown University and Research Scientist at the Centers for Behavioral and Preventive Medicine (CBPM) of The Miriam Hospital. DPHB and CBPM are dedicated to supporting K awardees from the completion of their training award activities to the transition into independent NIH funding. The DPHB currently has over 200 ongoing studies and $50 million in externally sponsored research and is dedicated to supporting early faculty in their transition to independence. Dr. Norris will apply the skills acquired through the proposed training activities to the development of theoretically-sound and evidence-based prevention programming to reduce alcohol misuse among sexual minority women. Specifically, Dr. Norris will develop a prevention program to reduce heavy alcohol use through three aims: (1) Formative needs assessment: (1a) systematic review of theoretical models of sexual minority women’s alcohol use, and (1b) in-depth interviews (N = 20) to guide intervention development through participatory engagement; (2) Refinement of treatment materials and delivery: (2a) secondary data analyses to determine meaningful normative feedback for sexual minority women (Kaysen), and (2b) cognitive interviews (N = 10) to guide the development of the intervention through participatory engagement; (3) Pilot randomized controlled trial (N = 70) comparing the intervention to an attention-matched control group to determine the feasibility and acceptability of the intervention, with a secondary focus on preliminary efficacy to guide future grant proposals.