Meaningful Activities and Alzheimer's Disease and Related Dementias

有意义的活动与阿尔茨海默病和相关痴呆症

• 批准号: 10037924
• 负责人: Alexander Keliimoeanu Smith
• 金额: $ 19.73万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10037924
• 关键词: Address; Admission activity; Aging; Alzheimer' s disease related dementia; Area; Award; Behavioral Research; Bioethical Issues; Books; Caring; Cessation of life; Cognition; Cognitive; Collaborations; Data; Data Set; Decision Making; Dementia; Elderly; Faculty; Family; Geriatrics; Gerontology; Goals; Health; Health Care Costs; Human; Intervention; Investments; Journals; Knowledge; Laboratories; Link; Measures; Medical; Medicare; Medicare claim; Mentors; Nursing Homes; Outcome; Outcome Measure; Palliative Care; Peer Review; Personal Satisfaction; Persons; Policies; Predictive Factor; Publications; Quality of life; Reading; Religion and Spirituality; Research; Research Personnel; Research Project Grants; Research Support; Resources; Risk; Self Care; Services; Shapes; Social support; Soil; Time; Work; career; career development; design; disability; experience; improved; leadership development; mortality; online resource; outcome forecast; patient oriented; patient oriented research; podcast; predictive modeling; prognostic index; recruit; social; social factors; trend

Project Abstract/Summary The research proposed for this award offers an outstanding opportunity to meet my career goals of: (1) becoming a leading mentor in geriatrics and palliative care; and (2) to pursue a new direction of research that addresses meaningful activities for older adults with Alzheimer’s disease and related dementias. My currently- supported research includes two R01 awards focused on developing better prognostic models for older adults in general and older adults with Alzheimer’s disease and related dementias. A central theme of both R01 awards is that older adults care about more than survival, they care about their risk for developing disability and losing their independence. Thus, our prognostic models will be designed to estimate time to death, time to disability, time to difficulty with cognitively demanding daily tasks, and time to nursing home admission. My proposed research leverages these data and intellectual resources for a new research direction, which will explore the relationship between Alzheimer’s disease and related dementias and activities that are important to older adults. This work is an extension of our central theme of focusing on outcomes that matter to older adults other than survival. Older adults care not just about survival and independence in self-care activities, a rather narrow view of the human experience, they care about being able to participate in activities that give their lives meaning and value. Meaningful activities might include attending religious services, reading books, spending time with family, or gardening. Little is known, however, about the relationship between participation in meaningful activities and Alzheimer’s disease and related dementias. A central premise for this project is that maintaining participation in meaningful activities is essential to quality of life for older adults with Alzheimer’s disease and related dementias. We will use the NHATS-Medicare linked datasets for this research, datasets we already own and use. These datasets will serve as a rich laboratory for a variety of mentored projects. The specific aims of the project are as follows: (1) To ascertain medical and social factors associated with maintaining participation in meaningful activities for older adults with Alzheimer’s disease and related dementias; and (2) To determine the association between participation in meaningful activities and health outcomes: quality of life, mortality, and healthcare costs over time for older adults with Alzheimer’s disease and related dementias. To accomplish my career goal of becoming a leading mentor in geriatrics and palliative care, my career development objectives during this award are: (1) to accelerate collaboration with palliative care; (2) to recruit mentees from diverse backgrounds; and (3) to engage in professional leadership development.

项目摘要/摘要 该奖项建议的研究为实现我的职业目标提供了一个绝佳的机会：(1) 成为老年病学和姑息治疗的领先导师；以及(2)追求一个新的研究方向， 为患有阿尔茨海默病和相关痴呆症的老年人解决有意义的活动。我目前的- 支持的研究包括两个R01奖，重点是为老年人开发更好的预后模型 一般情况下，患有阿尔茨海默病和相关痴呆的老年人。R01和R01的中心主题 奖励是老年人关心的不仅仅是生存，他们关心的是他们发展为残疾的风险 并失去他们的独立性。因此，我们的预测模型将被设计为估计死亡时间、 残疾，在日常认知任务中遇到困难的时间，以及入住养老院的时间。我的 拟议的研究利用这些数据和智力资源来进行新的研究方向，这将 探索阿尔茨海默病与相关痴呆症的关系以及对 上了年纪的人。这项工作是我们关注对老年人有意义的结果这一中心主题的延伸 而不是生存。老年人在自我照顾活动中不仅关心生存和独立，而是 狭隘地看待人类体验，他们关心的是能够参与给他们生命的活动 意义和价值。有意义的活动可能包括参加宗教仪式，阅读书籍，消费 与家人在一起的时间，或园艺的时间。然而，人们对参与社会变革之间的关系知之甚少。 有意义的活动和阿尔茨海默病以及相关的痴呆症。这个项目的一个主要前提是 保持有意义的活动对阿尔茨海默病老年患者的生活质量至关重要 疾病和相关痴呆症。我们将为这项研究使用NHATS-Medicare关联数据集、数据集 我们已经拥有和使用了。这些数据集将作为各种指导项目的丰富实验室。这个 该项目的具体目标如下：(1)确定与以下方面有关的医学和社会因素 为患有阿尔茨海默病及相关疾病的老年人持续参与有意义的活动 痴呆症；以及(2)确定参加有意义的活动与健康之间的联系 结果：随着时间的推移，患有阿尔茨海默病的老年人的生活质量、死亡率和医疗费用 相关痴呆症。为了实现我的职业目标，成为一名老年医学和姑息治疗领域的领先导师 CARE，我在这个奖项期间的职业发展目标是：(1)加快与姑息治疗的合作 关怀；(2)招募不同背景的学员；(3)从事专业领导 发展。