Pilot / Exploratory Studies Core (PESC)

项目摘要-试点和探索性研究核心(PESC) 试点和探索性研究核心(PESC)的总体目标是促进创新和 有希望的研究涉及老年残疾的预测因素、结果和改善，特别是 在脆弱的人群中。此续订申请建立在OAIC PESC在 在过去的9年里，我们支持来自不同学术资历的学者，从 从住院医生到高级教员。迄今为止，OAIC PESC学者的影响是巨大的，结果是 超过1600万美元的联邦资金。对于这个周期，我们特别关注紧张的 向独立过渡的初级教员面临的压力以及促进他们未来发展的机会 我们的OAIC主题领域的项目和职业发展。因此，我们将重点支持青少年 已经获得K奖并正在准备向独立过渡的学者--即通过 支持试点、探索性和初步研究，以促成第一个R01或同等奖项。我们会 此外，保持灵活性，优先考虑来自代表性不足背景的学者 股权研究，尽管它们可能处于培训的早期阶段(即学前阶段)。PESC的具体目标 主要研究内容如下：(1)确定对老龄化研究感兴趣或致力于老龄化研究的有前途的初级学者 关于晚年残疾的医学和社会决定因素，并支持他们从职业生涯过渡 开发奖为R01/等值奖，包括试点和试探性资金；(2)整合培训 和支持PESC的活动(重点是从K到R的过渡)，并与REC密切合作(这 专注于获得K-奖)，以开发一个无缝的支持计划，从预科研究员到 副教授；(3)为PESC学者提供研究设计、分析、招聘和 通过使用OAIC核心留住多样化和弱势群体，特别是数据和 分析核心(DAC)和脆弱老龄化研究核心(VARC)；(4)整合PESC研究和 来自加州大学旧金山分校临床和翻译科学研究所(CTSI)的学者，该中心 为不同社区的老龄化服务，弱势群体中心，以及其他相关资源 在加州大学旧金山分校；以及(5)通过为以下方面提供具体支持，促进老龄研究人员的多样性 来自不同背景、申请PESC资助的试点获奖候选人。

PROJECT SUMMARY ABSTRACT – Pilot and Exploratory Studies Core (PESC) The overall goal of the Pilot and Exploratory Studies Core (PESC) is to promote innovative and promising research addressing the predictors, outcomes and amelioration of late-life disability, especially in vulnerable populations. This renewal application builds on the success of the OAIC PESC over the past 9 years in which we have supported scholars from across the academic spectrum of seniority, from residents to senior faculty. The impact of the OAIC PESC Scholars to date has been significant, resulting in over $16 million in federal funding. For this cycle, we are placing special attention on the intense pressures placed on junior faculty transitioning to independence and opportunities to catalyze their future projects and career growth in our OAIC theme area. As a result, we will focus on supporting junior scholars who already have a K award and are preparing for the transition to independence – namely, by supporting pilot, exploratory and preliminary studies to facilitate a first R01 or equivalent award. We will additionally maintain flexibility to prioritize scholars from underrepresented backgrounds interested in in equity research, though they may be at earlier stages in training (i.e., pre-K). The PESC specific aims are as follows: (1) Identify promising junior scholars interested in or committed to aging research focused on the medical and social determinants of late-life disability, and support their transition from career development awards to R01/equivalent awards with pilot and exploratory funding; (2) Integrate training and support activities of the PESC (which is focused on K to R transitions) closely with the REC (which is focused on obtaining K-awards) to develop a seamless program of support from pre-K fellows to Associate Professors; (3) Provide PESC Scholars support in study design, analysis, recruitment and retention of diverse and vulnerable populations through use of the OAIC Cores, specifically the Data and Analysis Core (DAC) and the Vulnerable Aging Research Core (VARC); (4) Integrate PESC studies and scholars with resources from the UCSF Clinical and Translational Science Institute (CTSI), the Center for Aging in Diverse Communities, the Center for Vulnerable Populations, and other relevant resources at UCSF; and (5) Promote diversity among researchers in aging, through offering specific support for pilot award candidates from diverse backgrounds who apply for PESC funding.