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Juvenile Myositis

Juvenile Myositis
青少年肌炎
批准号：
10007538
负责人：
James Inglese
金额：
$17.05万
依托单位：
NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10007538
关键词：
AdolescentAffectAutoimmune DiseasesBiological AssayCalcinosisCellsChildCollaborationsContractureDermatomyositisDiseaseEnvironmental Risk FactorExanthemaFinancial SupportFoundationsGastrointestinal tract structureGeneticGoalsImmune systemLifeMuscleMuscle WeaknessMyositisPathogenesisPathway interactionsPolymyositisSkinSymptomsTissuesUlcerassay developmentbasedesignexperiencesmall molecule libraries

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中文摘要
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英文摘要
Juvenile myositis (JM) is an autoimmune disease targeting muscles, skin and other tissues caused by yet to be determined genetic and environmental factors. With financial support from the Cure JM Foundation in collaboration with Cure JM Foundation scientific advisors we have completed the design and development of assays based on genetic anomalies that may be contributing to JM pathogenesis. These assays are now being validated for use in the interrogation of chemical libraries for the identification of agents that modify these aberrant pathways.
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