Distinguishing Exposure to Secondhand and Thirdhand Tobacco Smoke and Electronic Cigarettes among U.S. Children based on Multiple Biomarker Profiles
根据多种生物标志物特征区分美国儿童接触二手和三手烟草烟雾和电子烟的情况
基本信息
- 批准号:10033879
- 负责人:
- 金额:$ 26.66万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-01 至 2022-08-31
- 项目状态:已结题
- 来源:
- 关键词:Aromatic Polycyclic HydrocarbonsAsthmaBiochemicalBiologicalBiological MarkersChildClassificationClinicalCotinineCoughingDataDermalDiagnosisDustElectronic cigaretteExposure toFingersFoundationsFrequenciesGoldHandHealthHealth Care VisitHealth HazardsHome environmentHospitalizationHousingIndividualIngestionInhalationInterviewLeftLinkLow incomeMethodsNational Health and Nutrition Examination SurveyNicotineNitrosaminesNitrous AcidNot Hispanic or LatinoOutcomeOxidantsPatient Self-ReportPatternPoliciesPrevalencePublic HealthRecommendationReportingResearchRiskSamplingSmokeSmokerSmokingSourceSurfaceSymptomsTobaccoTobacco smokeToxicant exposureUrineagedbasecarcinogenicityclassification algorithmcombustible cigarettecombustion productdemographicse-cigarette aerosolsenvironmental tobacco smokeenvironmental tobacco smoke exposurehealth care service utilizationimprovedinnovationinsightnon-smokernon-smokingpollutantpreventremediationsecondary analysisspecific biomarkersthirdhand smoketobacco productstoxicantvolatile organic compound
项目摘要
PROJECT SUMMARY
Thirdhand smoke (THS) is a distinct public health hazard resulting from aged secondhand smoke (SHS)
left behind from active smoking that absorbs into surfaces, dust, and furnishings. Multiple harmful toxicants
are in THS including nicotine that reacts with ambient oxidants (e.g., nitrous acid) to create carcinogenic
tobacco-specific nitrosamines and tobacco-nonspecific toxicants such as polycyclic aromatic hydrocarbons and
volatile organic compounds. Electronic cigarette (EC) aerosol exposure is a source of tobacco-specific
toxicants despite not generating by-products from combustion. Children are most vulnerable to THS and EC
aerosol exposure and its related effects. SHS and THS differ in composition and can be assessed with
biomarkers in biological samples of children with varying tobacco smoke exposure (TSE) levels, which is the
cumulative exposure to SHS and THS. Methods to distinguish THS from SHS in nonsmokers are limited to
assessing self-report, THS-related main metabolites and NNAL-to-cotinine ratios. Currently, there are no gold
standard TSE biomarkers to differentiate exposure to THS from exposure to SHS or exposure to ECs from
combustible tobacco products. Our research and others indicates child TSE results in negative health
outcomes and EC aerosol exposure is linked with asthma symptoms. It is crucial to examine existing tobacco-
specific and nonspecific biomarkers to assess children’s exposure to diverse tobacco/nicotine products and
heterogeneous pollutants. This will provide insight on TSE classification in children and disentangle related
health effects. Thus, we propose to conduct an innovative secondary analysis of National Health and Nutrition
Examination Survey (NHANES) 2013-2016 data. This project will be the first to examine the prevalence,
contributions, and health risks of exposure to SHS and THS among children presumed to be unexposed to any
tobacco smoke and among children exposed to EC aerosol only. We will examine multiple biomarkers since
proportions in SHS, THS, and likely EC aerosol, differ. NHANES data will be analyzed to distinguish child TSE
groups: 1) Mixed SHS and THS group (MEG): lives with nonsmokers or smokers of combustible products only,
reported SHS; 2) Predominant THS group (TEG): lives with nonsmokers or smokers, no reported SHS; 3)
Predominant EC group (ECG): lives with EC only users, reported EC aerosol exposure; and 4) No/minimal
TSE group (NEG): lives with nonsmokers, no reported SHS. First, we will compare tobacco-specific biomarker
data with interview data to validate self-report and distinguish children into TSE groups. Then, we will use
classification algorithms to identify a set of tobacco-specific and nonspecific biomarkers and ratios that best
differentiates between TSE groups. Lastly, associations between TSE groups and demographics, and clinical
and healthcare utilization patterns will be examined. The potential for generating results to inform the
FDA-CTP is substantial as the use of child TSE biomarkers is key to assess the levels of harm
attributable to exposure from THS only and EC aerosol only, which are currently unknown.
项目总结
项目成果
期刊论文数量(0)
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Ashley L Merianos其他文献
Ashley L Merianos的其他文献
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{{ truncateString('Ashley L Merianos', 18)}}的其他基金
Distinguishing Exposure to Secondhand and Thirdhand Tobacco Smoke and Electronic Cigarettes among U.S. Children based on Multiple Biomarker Profiles
根据多种生物标志物特征区分美国儿童接触二手和三手烟草烟雾和电子烟的情况
- 批准号:
10251269 - 财政年份:2020
- 资助金额:
$ 26.66万 - 项目类别:
Reducing Secondhand Smoke Exposure Among Pediatric Patients in the Emergency Department Setting
减少急诊室儿科患者的二手烟暴露
- 批准号:
10222632 - 财政年份:2017
- 资助金额:
$ 26.66万 - 项目类别:
Reducing Secondhand Smoke Exposure Among Pediatric Patients in the Emergency Department Setting
减少急诊室儿科患者的二手烟暴露
- 批准号:
9367361 - 财政年份:2017
- 资助金额:
$ 26.66万 - 项目类别:
Reducing Secondhand Smoke Exposure Among Pediatric Patients in the Emergency Department Setting
减少急诊室儿科患者的二手烟暴露
- 批准号:
9980325 - 财政年份:2017
- 资助金额:
$ 26.66万 - 项目类别:
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