Computerized tests of cognitive decline in presymptomatic Alzheimer’s disease

阿尔茨海默病症状前认知能力下降的计算机化测试

• 批准号: 10039211
• 负责人: Peter Pebler
• 金额: $ 20.23万
• 依托单位: NEUROBEHAVIORAL SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-12-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10039211
• 关键词: Administrative Supplement; Affect; Age; Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer' s disease risk; American; Benchmarking; California; Clinic; Clinical Trials; Cognitive; Computer Security; Cooperative Research and Development Agreement; Data; Data Analyses; Data Protection; Data Security; Databases; Dementia; Deterioration; Enrollment; Ensure; Funding; Generations; Genetic Risk; Goals; Gold; Health Insurance Portability and Accountability Act; Healthcare; Healthcare Systems; Hospitals; Hour; Human Resources; Impaired cognition; Individual; Infrastructure; Institutional Review Boards; Licensing; Literature; Longitudinal Studies; Manuals; Manuscripts; Medical; Medical center; Memory; Paper; Participant; Patient Recruitments; Patients; Peer Review; Phase; Play; Population; Procedures; Property; Protocols documentation; Psychometrics; Publications; Research; Research Design; Research Personnel; Resources; Risk; Role; Scientist; Secure; Site; Software Engineering; Systems Integration; Test Result; Testing; Training; care burden; cloud based; cognitive testing; computerized; cost; data hosting; data management; design; field study; inclusion criteria; innovation; interest; meetings; mental function; novel therapeutics; outreach; recruit; software development; success; symposium; therapy design; usability; volunteer; web site

Abstract. We are requesting an administrative supplement to expand participant recruitment and testing to the VA Northern California Healthcare System (VANCHCS) in Martinez. The supplement would reduce five potential risks to the long-term scientific impact of second generation California Cognitive Assessment Battery (CCAB-2) tests: • Recruitment. Participant recruitment has been compromised by the establishment of a California-funded Alzheimer’s Disease Research Center at our original recruitment site. Expanding recruitment and testing to the VANCHCS will resolve this problem and increase participant diversity: there are more than 32,000 eligible older participants within the VANCHCS catchment who meet study inclusion criteria. • Milestone completion. Our research plan calls for nearly 5,000 assessments over three years, with nearly 2,300 assessments planned in Phase II, year 1. This would require 9.1 assessments per day during year 1, i.e. approximately 20 hours of testing. The assistance of trained VA staff and the established VANCHCS’ infrastructure will assist us in meeting these testing challenges. • CCAB-2 compatibility with hospital data security protocols. In the original application, CCAB-2 testing was limited to NBS offices. The supplement will support the software development and testing needed to ensure that CCAB-2 tests function within secure healthcare IT networks with extensive data protection safeguards and HIPAA-compliant protocols. • CCAB-2 usability and robustness. In the original application, CCAB-2 test administration was limited to NBS personnel. This administrative supplement will enable extensive field testing by VA scientists and clinicians to ensure CCAB-2 robustness and usability prior to commercial launch. • Disseminating results. The extensive testing demands in the original application would limit NBS scientific outreach. The supplement will support VA scientists in publicizing CCAB-2 capabilities at conferences, Alzheimer’s Disease Centers, grand rounds, research labs, department colloquia, and in peer-reviewed publications.

抽象的。我们要求提供行政补充，以扩大参与者招募 并在马丁内斯对退伍军人管理局北加州医疗系统(VANCHCS)进行测试。这个 补充剂将减少第二种药物对长期科学影响的五个潜在风险 第二代加州认知评估成套测验(CCAB-2)： ·招聘。参与者招募因建立了一个 加州资助的阿尔茨海默病研究中心在我们最初的招聘网站。 将招聘和测试扩大到VANCHCS将解决这一问题并增加 参与者多样性：有超过32,000名符合条件的老年参与者 符合研究纳入标准的VANCHCS集水区。 ·里程碑式的完成。我们的研究计划要求在三个月内进行近5,000次评估 几年，计划在第二阶段、第一年进行近2300次评估。这将需要9.1 在第一年期间每天进行评估，即大约20个小时的测试。的协助 训练有素的退伍军人管理局工作人员和成熟的VANCHCS基础设施将帮助我们满足这些要求 测试挑战。 ·CCAB-2与医院数据安全协议的兼容性。在原始应用程序中， CCAB-2测试仅限于国家统计局办公室。本附录将支持该软件 确保CCAB-2测试在安全范围内运行所需的开发和测试 具有广泛的数据保护保护和HIPAA兼容的医疗保健IT网络 协议。 ·CCAB-2的可用性和健壮性。在最初的应用程序中，CCAB-2测试管理 仅限于国家统计局人员。这一行政补充将使更广泛的领域 由退伍军人管理局科学家和临床医生进行测试，以确保CCAB-2在 商业发射。 ·传播成果。原始应用程序中广泛的测试需求将限制 国家统计局的科学外展。该副刊将支持退伍军人管理局的科学家宣传CCAB-2 在会议、阿尔茨海默病中心、大型轮回会议、研究实验室、 新闻部座谈会以及同行评议的出版物。