Computerized tests of cognitive decline in presymptomatic Alzheimer’s disease

阿尔茨海默病症状前认知能力下降的计算机化测试

• 批准号: 10408563
• 负责人: Peter Pebler
• 金额: $ 25万
• 依托单位: NEUROBEHAVIORAL SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10408563
• 关键词: Accent; Administrative Supplement; Affect; Age; Alzheimer' s Disease; Alzheimer' s disease diagnosis; Alzheimer' s disease pathology; Alzheimer' s disease risk; American; Area; Back; Benchmarking; California; Central America; Chile; Church; Clinical Research; Clinical Trials; Clinical assessments; Cognition; Cognitive; Consensus; Data; Data Analyses; Data Collection; Dementia; Demographic Factors; Deterioration; Digit structure; Economically Deprived Population; Elderly; Enrollment; Ethnic group; Face; Feedback; Frequencies; Genetic Risk; Genetic Transcription; Healthcare; Hispanic; Hispanic Americans; Hispanic Populations; Home; Impaired cognition; Improve Access; Incidence; Individual; Instruction; Language; Learning; Location; Manuals; Manuscripts; Materials Testing; Measures; Medical; Memory; Mexican; Mexico; Minor; Minority; Modification; Neighborhoods; Not Hispanic or Latino; Paper; Participant; Patients; Performance; Phase; Play; Population; Procedures; Research; Resources; Risk; Role; Rural; Sampling; San Francisco; South America; Spain; Speech; Stimulus; Test Result; Testing; Text; Time; Training; Translating; Translations; Transportation; Underserved Population; Voice; automated analysis; automated speech recognition; base; bilingualism; care burden; cloud based; cognitive testing; computerized; cost; design; disadvantaged population; experimental study; home test; improved; innovation; machine translation; mental function; novel therapeutics; outreach; posters; quality assurance; recruit; remote grading; research study; rural area; social media; success; therapy design

Abstract. Hispanic Americans are the largest and fastest growing US minority and, over coming decades, will show the largest relative increase in Alzheimer’s disease (AD) incidence of any ethnic group. However, Spanish-speaking Hispanics have been largely excluded from clinical trials and research studies for several reasons: (1) Only 5.5% of US neuropsychologists have sufficient fluency to administer cognitive tests in Spanish; (2) Existing Spanish-language cognitive tests lack adequate norms for older Hispanic Americans, and (3) many Hispanics live in rural or hard-to-reach locations that make test administration challenging. Here, we propose to create a Spanish version of the California Cognitive Assessment Battery (CCAB) and gather normative data from 256 older Spanish-speaking Hispanics, telemedically tested in their homes. CCAB-Spanish will significantly enhance access to cognitive testing for US Hispanics for several reasons: (1) Automated and computerized test delivery and scoring means examiners with limited Spanish fluency can administer CCAB-Spanish tests, with on-call interpreters as needed; (2) Nationwide telemedical administration reaches populations underserved by manual testing; and (3) A single examiner can remotely test multiple subjects concurrently making clinical assessments of cognition economically feasible in economically disadvantaged populations. The supplement will further enhance the long-term scientific and commercial impact of the CCAB, and provide older Spanish-speaking US residents with improved access to cognitive testing.

抽象的。西班牙裔美国人是美国人数最多、增长最快的少数民族， 几十年来，阿尔茨海默病（AD）的发病率将出现最大的相对增长， 族群。然而，讲西班牙语的西班牙裔人在很大程度上被排除在临床之外， 有几个原因：（1）只有5.5%的美国神经心理学家 足够流利地使用西班牙语进行认知测试;（2）现有的西班牙语 认知测试缺乏足够的规范，老年西班牙裔美国人，（3）许多西班牙裔生活在 在农村或难以到达的地方，使测试管理具有挑战性。在此，我们建议 创建西班牙版的加州认知评估组合（CCAB）并收集 来自256名讲西班牙语的西班牙裔老年人的规范性数据，在他们的家中进行远程医疗测试。 CCAB-Spanish将大大提高美国西班牙裔的认知测试， 几个原因：（1）自动化和计算机化的测试交付和评分意味着考官 西班牙语流利程度有限的人可以管理CCAB西班牙语考试， （2）全国范围内的远程医疗管理覆盖了人工服务不足的人群 测试;以及（3）单个检查员可以同时远程测试多个科目， 经济困难患者认知经济可行性的临床评估 人口。该补充将进一步提高长期的科学和商业 CCAB的影响，并为讲西班牙语的美国老年居民提供更好的获得 认知测试

项目成果

The California Cognitive Assessment Battery (CCAB).

• DOI: 10.3389/fnhum.2023.1305529
• 发表时间: 2023
• 期刊: FRONTIERS IN HUMAN NEUROSCIENCE
• 影响因子: 2.9
• 作者: Woods, David;Pebler, Peter;Johnson, David K.;Herron, Timothy;Hall, Kat;Blank, Mike;Geraci, Kristi;Williams, Garrett;Chok, Jas;Lwi, Sandy;Curran, Brian;Schendel, Krista;Spinelli, Maria;Baldo, Juliana
• 通讯作者: Baldo, Juliana