Computerized tests of cognitive decline in presymptomatic Alzheimer’s disease

阿尔茨海默病症状前认知能力下降的计算机化测试

• 批准号: 10408563
• 负责人: Peter Pebler
• 金额: $ 25万
• 依托单位: NEUROBEHAVIORAL SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10408563
• 关键词: Accent; Administrative Supplement; Affect; Age; Alzheimer' s Disease; Alzheimer' s disease diagnosis; Alzheimer' s disease pathology; Alzheimer' s disease risk; American; Area; Back; Benchmarking; California; Central America; Chile; Church; Clinical Research; Clinical Trials; Clinical assessments; Cognition; Cognitive; Consensus; Data; Data Analyses; Data Collection; Dementia; Demographic Factors; Deterioration; Digit structure; Economically Deprived Population; Elderly; Enrollment; Ethnic group; Face; Feedback; Frequencies; Genetic Risk; Genetic Transcription; Healthcare; Hispanic; Hispanic Americans; Hispanic Populations; Home; Impaired cognition; Improve Access; Incidence; Individual; Instruction; Language; Learning; Location; Manuals; Manuscripts; Materials Testing; Measures; Medical; Memory; Mexican; Mexico; Minor; Minority; Modification; Neighborhoods; Not Hispanic or Latino; Paper; Participant; Patients; Performance; Phase; Play; Population; Procedures; Research; Resources; Risk; Role; Rural; Sampling; San Francisco; South America; Spain; Speech; Stimulus; Test Result; Testing; Text; Time; Training; Translating; Translations; Transportation; Underserved Population; Voice; automated analysis; automated speech recognition; base; bilingualism; care burden; cloud based; cognitive testing; computerized; cost; design; disadvantaged population; experimental study; home test; improved; innovation; machine translation; mental function; novel therapeutics; outreach; posters; quality assurance; recruit; remote grading; research study; rural area; social media; success; therapy design

Abstract. Hispanic Americans are the largest and fastest growing US minority and, over coming decades, will show the largest relative increase in Alzheimer’s disease (AD) incidence of any ethnic group. However, Spanish-speaking Hispanics have been largely excluded from clinical trials and research studies for several reasons: (1) Only 5.5% of US neuropsychologists have sufficient fluency to administer cognitive tests in Spanish; (2) Existing Spanish-language cognitive tests lack adequate norms for older Hispanic Americans, and (3) many Hispanics live in rural or hard-to-reach locations that make test administration challenging. Here, we propose to create a Spanish version of the California Cognitive Assessment Battery (CCAB) and gather normative data from 256 older Spanish-speaking Hispanics, telemedically tested in their homes. CCAB-Spanish will significantly enhance access to cognitive testing for US Hispanics for several reasons: (1) Automated and computerized test delivery and scoring means examiners with limited Spanish fluency can administer CCAB-Spanish tests, with on-call interpreters as needed; (2) Nationwide telemedical administration reaches populations underserved by manual testing; and (3) A single examiner can remotely test multiple subjects concurrently making clinical assessments of cognition economically feasible in economically disadvantaged populations. The supplement will further enhance the long-term scientific and commercial impact of the CCAB, and provide older Spanish-speaking US residents with improved access to cognitive testing.

摘要。西班牙裔美国人是美国人数最多、增长最快的少数族裔，而且正在逐渐崛起

项目成果

The California Cognitive Assessment Battery (CCAB).

• DOI: 10.3389/fnhum.2023.1305529
• 发表时间: 2023
• 期刊: FRONTIERS IN HUMAN NEUROSCIENCE
• 影响因子: 2.9
• 作者: Woods, David;Pebler, Peter;Johnson, David K.;Herron, Timothy;Hall, Kat;Blank, Mike;Geraci, Kristi;Williams, Garrett;Chok, Jas;Lwi, Sandy;Curran, Brian;Schendel, Krista;Spinelli, Maria;Baldo, Juliana
• 通讯作者: Baldo, Juliana