NIDA CENTER FOR GENETIC STUDIES. MARCH 14, 2019 - SEPTEMBER 16, 2019. N01DA-18-7797. TASK ORDER 3

该合同是由需要找到基因变异，有助于药物成瘾的脆弱性和共病性疾病的病因，如果临床数据和生物材料在研究人员之间共享的目标更容易实现。该奖项继续目前的NIDA遗传研究中心（中心）的活动，共同指导博士杰伊A。Tischfield和Andrew I.罗格斯大学的布鲁克斯和负责维护临床数据的华盛顿大学的约翰·P·赖斯博士进行了交谈。近二十年来，该中心已经生产了冷冻保存的淋巴细胞，淋巴母细胞系，血液或唾液样本的DNA，以及NGC研究人员提交的血液样本的RNA。在某些情况下，这些DNA已提供给NGC成员用于多态性微卫星和/或SNP标记的基因分型或用于DNA重新测序。这些基因型为连锁、SIB对、全基因组关联（GWAS）和其他分析提供了基础，这些分析将定义影响与药物滥用、药物滥用相关行为和成瘾易感性相关的内表型和临床表型的基因变异。该中心还维护一个关于受试者家庭结构、年龄、性别、临床状态和诊断的匿名数据数据库。个人PI可以通过安全的、受密码保护的网站访问其数据。目标是最终使生物样本和数据可供更广泛的NIDA批准的研究人员使用。

This contract is driven by the need to find gene variants that contribute to the etiology of drug addiction vulnerability and comorbid disorders, a goal more readily attained if clinical data and biological materials are shared among researchers. The award continues activities of the current NIDA Center for Genetic Studies (Center) Co-directed by Drs. Jay A. Tischfield and Andrew I. Brooks of Rutgers University with a subcontract to Dr. John P. Rice of Washington University who maintains the clinical data. For nearly twenty years, the Center has produced cryopreserved lymphocytes, lymphoblast cell lines, DNA from blood or saliva samples, and RNA from blood samples submitted by NGC investigators. In some cases these DNA have been provided to the NGC members for genotyping of polymorphic microsatellite and/or SNP markers or for DNA re-sequencing. These genotypes provide the bases for linkage, SIB pair, genome-wide association (GWAS) and other analyses that will define gene variants that influence both endophenotypes and clinical phenotypes related to drug abuse, drug abuse-related behaviors and addiction vulnerability. The Center also maintains a database of anonymized data on family structure, age, sex, clinical status, and diagnoses of subjects. Individual PIs may access their data through a secure, password-protected website. The goal is to eventually make both the biosamples and data available to a broader range of NIDA-approved researchers.