NIDA ADOLESCENT BRAIN COGNITIVE DEVELOPMENT STUDY (ABCD) GENOME CENTER AND BIOSPECIMENS REPOSITORY. SEPTEMBER 17, 2020 - SEPTEMBER 16, 2021. N01DA-18-

这份合同的驱动因素是需要找到导致药物成瘾易感性和共病障碍的基因变异，如果研究人员共享临床数据和生物材料，这一目标就更容易实现。该奖项延续了目前由罗格斯大学的Jay A.Tischfield博士和Andrew I.Brooks博士共同领导的NIDA青少年脑认知发展研究(ABCD)基因组中心和生物谱系资料库以及NIDA遗传研究中心(中心)的活动，并将其分包给负责维护临床数据的华盛顿大学的约翰·P·赖斯博士。近20年来，该中心一直在生产冷冻保存的淋巴细胞、淋巴母细胞系、血液或唾液样本中的DNA，以及由NGC研究人员提交的血液样本中的RNA。在某些情况下，这些DNA被提供给NGC成员，用于多态微卫星和/或SNP标记的基因分型，或用于DNA重新测序。这些基因类型为连锁、SIB配对、全基因组关联和其他分析提供了基础，这些分析将定义影响与药物滥用、药物滥用相关行为和成瘾易感性相关的内表型和临床表型的基因变异。该中心还维护一个匿名数据数据库，其中包括家庭结构、年龄、性别、临床状况和受试者的诊断。个人私人投资者可以通过安全的、受密码保护的网站访问他们的数据。其目标是最终将生物样本和数据提供给更广泛的NIDA批准的研究人员。

This contract is driven by the need to find gene variants that contribute to the etiology of drug addiction vulnerability and comorbid disorders, a goal more readily attained if clinical data and biological materials are shared among researchers. The award continues activities of the current NIDA Adolescent Brain Cognitive Development Study (ABCD) genome center and biospecimens repository and NIDA Center for Genetic Studies (Center) Co-directed by Drs. Jay A. Tischfield and Andrew I. Brooks of Rutgers University with a subcontract to Dr. John P. Rice of Washington University who maintains the clinical data. For nearly twenty years, the Center has produced cryopreserved lymphocytes, lymphoblast cell lines, DNA from blood or saliva samples, and RNA from blood samples submitted by NGC investigators. In some cases these DNA have been provided to the NGC members for genotyping of polymorphic microsatellite and/or SNP markers or for DNA re-sequencing. These genotypes provide the bases for linkage, SIB pair, genome-wide association (GWAS) and other analyses that will define gene variants that influence both endophenotypes and clinical phenotypes related to drug abuse, drug abuse-related behaviors and addiction vulnerability. The Center also maintains a database of anonymized data on family structure, age, sex, clinical status, and diagnoses of subjects. Individual PIs may access their data through a secure, password-protected website. The goal is to eventually make both the biosamples and data available to a broader range of NIDA-approved researchers.