NIDA ADOLESCENT BRAIN COGNITIVE DEVELOPMENT STUDY (ABCD) GENOME CENTER AND BIOSPECIMENS REPOSITORY. SEPTEMBER 17, 2020 - SEPTEMBER 16, 2021. N01DA-18-

NIDA 青少年大脑认知发展研究 (ABCD) 基因组中心和生物样本存储库。

• 批准号: 10288302
• 负责人: JAY TISCHFIELD
• 金额: $ 201.23万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-17 至 2021-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10288302
• 关键词: Adolescent; Age; Award; Biocompatible Materials; Biological Specimen Banks; Blood; Blood specimen; Brain; Cell Line; Clinical; Clinical Data; Communities; Computer software; Contracts; Cryopreservation; DNA; Data; Data Storage and Retrieval; Databases; Development; Diagnosis; Disease; Drug Addiction; Drug abuse; Environmental Exposure; Etiology; Funding; Genetic; Genetic study; Genome; Genomics; Genotype; Goals; Grant; High-Throughput Nucleotide Sequencing; Human Genetics; Individual; Information Sciences; Link; Lymphocyte; Microsatellite Repeats; Molecular; National Institute of Drug Abuse; Phenotype; Process; RNA; Research; Research Personnel; Research Support; Resources; Rice; Saliva; Sampling; Secure; Serum; Support Contracts; System; United States National Institutes of Health; Universities; Washington; addiction; base; clinical diagnostics; clinical phenotype; cognitive development; comorbidity; cost effective; cyber infrastructure; data anonymization; database of Genotypes and Phenotypes; distributed data; drug abuse related behavior; endophenotype; epigenomics; family structure; genetic pedigree; genetic variant; genome wide association study; induced pluripotent stem cell; interoperability; lymphoblast; member; phenotypic data; repository; sex; web site

This contract is driven by the need to find gene variants that contribute to the etiology of drug addiction vulnerability and comorbid disorders, a goal more readily attained if clinical data and biological materials are shared among researchers. The award continues activities of the current NIDA Adolescent Brain Cognitive Development Study (ABCD) genome center and biospecimens repository and NIDA Center for Genetic Studies (Center) Co-directed by Drs. Jay A. Tischfield and Andrew I. Brooks of Rutgers University with a subcontract to Dr. John P. Rice of Washington University who maintains the clinical data. For nearly twenty years, the Center has produced cryopreserved lymphocytes, lymphoblast cell lines, DNA from blood or saliva samples, and RNA from blood samples submitted by NGC investigators. In some cases these DNA have been provided to the NGC members for genotyping of polymorphic microsatellite and/or SNP markers or for DNA re-sequencing. These genotypes provide the bases for linkage, SIB pair, genome-wide association (GWAS) and other analyses that will define gene variants that influence both endophenotypes and clinical phenotypes related to drug abuse, drug abuse-related behaviors and addiction vulnerability. The Center also maintains a database of anonymized data on family structure, age, sex, clinical status, and diagnoses of subjects. Individual PIs may access their data through a secure, password-protected website. The goal is to eventually make both the biosamples and data available to a broader range of NIDA-approved researchers.

该合同的驱动因素是寻找导致药物成瘾脆弱性和共病疾病病因的基因变异，如果研究人员之间共享临床数据和生物材料，则更容易实现这一目标。该奖项延续了当前 NIDA 青少年大脑认知发展研究 (ABCD) 基因组中心和生物样本库以及 NIDA 遗传研究中心（中心）的活动，由 NIDA 博士共同指导。罗格斯大学的 Jay A. Tischfield 和 Andrew I. Brooks 与华盛顿大学的 John P. Rice 博士签订了分包合同，后者负责维护临床数据。近二十年来，该中心生产了冷冻保存的淋巴细胞、淋巴母细胞系、血液或唾液样本中的 DNA，以及 NGC 研究人员提交的血液样本中的 RNA。在某些情况下，这些 DNA 已提供给 NGC 成员，用于多态性微卫星和/或 SNP 标记的基因分型或用于 DNA 重新测序。这些基因型为连锁、SIB对、全基因组关联（GWAS）和其他分析提供了基础，这些分析将定义影响与药物滥用、药物滥用相关行为和成瘾脆弱性相关的内表型和临床表型的基因变异。该中心还维护一个关于家庭结构、年龄、性别、临床状况和受试者诊断的匿名数据的数据库。个人 PI 可以通过受密码保护的安全网站访问其数据。目标是最终将生物样本和数据提供给更广泛的 NIDA 批准的研究人员。