NIDA ADOLESCENT BRAIN COGNITIVE DEVELOPMENT STUDY (ABCD) GENOME CENTER AND BIOSPECIMENS REPOSITORY. SEPTEMBER 17, 2020 - SEPTEMBER 16, 2021. N01DA-18-

NIDA 青少年大脑认知发展研究 (ABCD) 基因组中心和生物样本存储库。

• 批准号: 10288302
• 负责人: JAY TISCHFIELD
• 金额: $ 201.23万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-17 至 2021-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10288302
• 关键词: Adolescent; Age; Award; Biocompatible Materials; Biological Specimen Banks; Blood; Blood specimen; Brain; Cell Line; Clinical; Clinical Data; Communities; Computer software; Contracts; Cryopreservation; DNA; Data; Data Storage and Retrieval; Databases; Development; Diagnosis; Disease; Drug Addiction; Drug abuse; Environmental Exposure; Etiology; Funding; Genetic; Genetic study; Genome; Genomics; Genotype; Goals; Grant; High-Throughput Nucleotide Sequencing; Human Genetics; Individual; Information Sciences; Link; Lymphocyte; Microsatellite Repeats; Molecular; National Institute of Drug Abuse; Phenotype; Process; RNA; Research; Research Personnel; Research Support; Resources; Rice; Saliva; Sampling; Secure; Serum; Support Contracts; System; United States National Institutes of Health; Universities; Washington; addiction; base; clinical diagnostics; clinical phenotype; cognitive development; comorbidity; cost effective; cyber infrastructure; data anonymization; database of Genotypes and Phenotypes; distributed data; drug abuse related behavior; endophenotype; epigenomics; family structure; genetic pedigree; genetic variant; genome wide association study; induced pluripotent stem cell; interoperability; lymphoblast; member; phenotypic data; repository; sex; web site

This contract is driven by the need to find gene variants that contribute to the etiology of drug addiction vulnerability and comorbid disorders, a goal more readily attained if clinical data and biological materials are shared among researchers. The award continues activities of the current NIDA Adolescent Brain Cognitive Development Study (ABCD) genome center and biospecimens repository and NIDA Center for Genetic Studies (Center) Co-directed by Drs. Jay A. Tischfield and Andrew I. Brooks of Rutgers University with a subcontract to Dr. John P. Rice of Washington University who maintains the clinical data. For nearly twenty years, the Center has produced cryopreserved lymphocytes, lymphoblast cell lines, DNA from blood or saliva samples, and RNA from blood samples submitted by NGC investigators. In some cases these DNA have been provided to the NGC members for genotyping of polymorphic microsatellite and/or SNP markers or for DNA re-sequencing. These genotypes provide the bases for linkage, SIB pair, genome-wide association (GWAS) and other analyses that will define gene variants that influence both endophenotypes and clinical phenotypes related to drug abuse, drug abuse-related behaviors and addiction vulnerability. The Center also maintains a database of anonymized data on family structure, age, sex, clinical status, and diagnoses of subjects. Individual PIs may access their data through a secure, password-protected website. The goal is to eventually make both the biosamples and data available to a broader range of NIDA-approved researchers.

该合同的驱动是由于需要寻找有助于药物成瘾脆弱性和合并症的病因的基因变异体，如果研究人员共享临床数据和生物材料，则更容易实现这一目标。该奖项继续进行了当前NIDA青少年脑认知发展研究（ABCD）基因组中心和生物测量存储库以及由DRS共同执导的NIDA遗传研究中心（Center）。罗格斯大学的杰伊·蒂奇菲尔德（Jay A.近20年来，该中心产生了冷冻保存的淋巴细胞，淋巴细胞细胞系，血液或唾液样品的DNA以及NGC研究者提交的血液样本的RNA。在某些情况下，这些DNA已向NGC成员提供了多态微卫星和/或SNP标记的基因分型，或者用于DNA重新测试。这些基因型为连锁，SIB对，全基因组关联（GWAS）提供了基础，以及其他分析，这些分析将定义基因变异，这些基因变异型会影响内类型和与药物滥用，与药物滥用相关的行为和成瘾性相关的临床表型。该中心还保留了有关家庭结构，年龄，性别，临床状况和受试者诊断的匿名数据数据库。单个PI可以通过安全，受密码保护的网站访问其数据。目的是最终将生物样本和数据提供给更广泛的NIDA批准的研究人员。