Integration of gustatory and somatosensory information in the tongue
舌头中味觉和体感信息的整合
基本信息
- 批准号:10039395
- 负责人:
- 金额:$ 22.47万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-05 至 2022-08-31
- 项目状态:已结题
- 来源:
- 关键词:AffectAftercareAnatomyAnteriorApplications GrantsBrainCalcitonin Gene-Related PeptideCalciumCapsaicinCellsChemicalsCircumvallate PapillaCranial NervesDataDetectionElementsFiberFingersFoodFutureGlossopharyngeal nerve structureGoalsGrantImageLightLocationMandibleModalityMusNerveNerve FibersNeuraxisNeuropeptidesNeurotransmittersNociceptionNociceptive StimulusNutritionalPerceptionPeripheralProcessResearch Project GrantsRhodamineRoleSensorySignal TransductionSliceSmell PerceptionSodium ChlorideStimulusStratified EpitheliumSubstance PSynapsesSystemTRPA channelTRPV1 geneTaste BudsTaste PerceptionTechniquesTemperatureTestingTimeTissuesTongueTouch sensationTransgenic AnimalsTrigeminal nerve structureafferent nerveallyl isothiocyanatecalcium indicatorcell typechorda tympaniexperimental studyhedonicimprovedlingual nervemultimodalitymultisensorynerve supplyneurotransmitter releaseoptogeneticspreservationresponsesignal processingsomatosensorytheoriestransmission process
项目摘要
PROJECT SUMMARY
Taste buds are the sensory elements responsible for the detection and elaboration of the taste signal.
In the anterior tongue, they are innervated by gustatory fibers (from the chorda tympani nerve) transmitting the
signal to the brain but also by a rich network of somatosensory fibers (from the lingual branch of the trigeminal
nerve) activated by nociceptive stimuli. This close proximity presents an ideal location to facilitate interactions
between the two systems. The main goal of this project is to better understand and characterize these
interactions at the tongue level, before further processing of the signal in the central nervous system. We will
use a variety of techniques in combination with transgenic animals to test the hypothesis that various
neuropeptides and neurotransmitters are released from somatosensory fibers and activate taste cells, which
causes a modulation of gustatory responses. We will take advantage of optogenetics to specifically stimulate
somatosensory fibers with light and study the effects of their activation on taste cells and taste responses. If
successful, this exploratory research project will support the theory that interactions between the gustatory and
somatosensory systems occur in the tongue and provide enough pilot data for a future grant application. The
data collected will expand our understanding of the multi-modal aspect of food perception and ultimately,
provide approaches to improve the hedonic value of nutritionally preferable foods.
项目摘要
味蕾是负责检测和加工味觉信号的感觉元件。
在舌前部,它们受味觉纤维(来自鼓索神经)的支配,
信号传递到大脑,但也通过丰富的躯体感觉纤维网络(来自三叉神经的舌分支
神经)由伤害性刺激激活。这种紧密的接近提供了一个理想的位置,以促进互动
两个系统之间。该项目的主要目标是更好地理解和描述这些
在中枢神经系统对信号进行进一步处理之前,在舌头水平上进行相互作用。我们将
使用各种技术与转基因动物相结合,以测试各种假设,
神经肽和神经递质从躯体感觉纤维释放并激活味觉细胞,
引起味觉反应的调节。我们将利用光遗传学的优势,
体感纤维与光,并研究其激活对味觉细胞和味觉反应的影响。如果
成功,这个探索性的研究项目将支持理论,味觉和
身体感觉系统出现在舌头上,为未来的拨款申请提供了足够的试点数据。的
收集的数据将扩大我们对食物感知的多模式方面的理解,
提供提高营养上优选的食物的享乐价值的方法。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Aurelie Vandenbeuch其他文献
Aurelie Vandenbeuch的其他文献
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{{ truncateString('Aurelie Vandenbeuch', 18)}}的其他基金
Integration of gustatory and somatosensory information in the tongue
舌头中味觉和体感信息的整合
- 批准号:
10255510 - 财政年份:2020
- 资助金额:
$ 22.47万 - 项目类别:
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