A Digital Therapeutic to Advance the Delivery of Effective Interventions for Suicide Prevention

数字疗法可促进有效预防自杀干预措施的实施

• 批准号: 10010336
• 负责人: Seth Feuerstein
• 金额: $ 48.1万
• 依托单位: OUI THERAPEUTICS, INC
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-23 至 2021-07-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10010336
• 关键词: Academy; Alcohol or Other Drugs use; Android; Anxiety; Apple; Caring; Cause of Death; Certification; Clinical; Clinical Trials; Clinical Trials Cooperative Group; Cognitive Therapy; Communities; Computer software; Connecticut; Development; Devices; Diagnosis; Emergency department visit; Esthetics; Exposure to; Feasibility Studies; Feedback; Feeling suicidal; Future; General Population; Goals; Health Technology; Healthcare; Hospitalization; Human; Individual; Inpatients; Interview; Length of Stay; Medical; Mental Health; Meta-Analysis; Methods; Movement; National Institute of Mental Health; Outcome; Outpatients; Participant; Patients; Persons; Phase; Population; Production; Psychiatric Diagnosis; Psychiatric Hospitals; Psychiatric therapeutic procedure; Public Health; Publishing; Randomized Controlled Trials; Reporting; Research; Resistance; Risk; Sampling; Site; Sleeplessness; Small Business Innovation Research Grant; Structure; Suicide; Suicide attempt; Suicide prevention; Techniques; Testing; Therapeutic; Therapeutic Intervention; Therapy Clinical Trials; Training; Treatment Protocols; United States; Work; base; cognitive training; combat; commercialization; design; digital; economic impact; effective intervention; efficacy testing; evidence base; experience; mHealth; mobile application; mobile computing; mortality; open label; prevent; programs; reducing suicide; response; suicidal risk; suicide rate; treatment program; trend; usability

ABSTRACT Suicide is a top ten cause of death in the US and rates of suicide have increased steadily for the last twenty years. Despite this, there is a paucity of research on treatment programs designed to reduce suicide attempts and none that include a digital therapeutic. In this Phase I SBIR application Oui Therapeutics, LLC proposes a project to: 1) create a beta version of the Oui app (called “Aviva”), a CBT-based digital therapeutic to reduce the risk of suicide across diagnoses; and 2) to test the usability and feasibility of the Beta version of Aviva in a single-group, open-label trial. The digital therapeutic being studied is built on face-to-face CBT treatment protocols proven to be effective in clinical trials. Successful execution of the goals of this Phase I project will generate a version of Aviva that is ready to be tested for efficacy with stabilized patients in a clinical trial. In the long term, this project will have a beneficial impact on the field of suicide prevention through the development of mobile technology designed to advance the delivery and dissemination of effective interventions.

摘要 自杀是美国十大死因之一，在过去的20年里，自杀率稳步上升。 年尽管如此，关于旨在减少自杀企图的治疗方案的研究仍然很少 没有一个包含数字治疗。在第一阶段SBIR申请中，Oui Therapeutics，LLC提出了一种 项目：1）创建Oui应用程序的测试版（称为“Aviva”），这是一种基于CBT的数字治疗， 跨诊断的自杀风险;以及2）测试Aviva Beta版在 单组、开放标签试验。正在研究的数字治疗是建立在面对面的CBT治疗基础上的 在临床试验中证明有效的方案。成功执行第一阶段项目的目标将 生成Aviva版本，准备在临床试验中对稳定患者进行疗效测试。在 从长远来看，这个项目将通过发展自杀预防领域产生有益的影响。 移动的技术，旨在推动有效干预措施的交付和传播。