A Self-Guided Mobile Intervention for Adults with Binge Eating and Obesity

摘要 肥胖和暴饮暴食是美国超过40%的成年人面临的严重健康问题。 肥胖引起的健康并发症占全国医疗预算的20%以上， 暴饮暴食的人的医疗费用比没有暴饮暴食的肥胖同龄人高18,152美元。 暴饮暴食的盛行和医疗费用的沉重负担突出了治疗的必要性 这消除了暴饮暴食并产生减肥效果。尽管如此，干预措施仍然很少。 解决这些并存的情况。在这个第一阶段的项目中，我们寻求建立一种数字治疗(称为 OTX-401)，将在第二阶段准备好在大型、多地点、动力充足的临床试验中进行测试。阳性 成果将是促进广泛实施和商业化的关键的第一步 数字治疗，以增强获得高度个性化的肥胖和暴食干预的机会。

ABSTRACT Obesity and comorbid binge eating are serious health problems for more than 40% of adults across the US.7 Health complications due to obesity comprise more than 20% of the nation’s healthcare budget, and the healthcare costs of individuals with binge eating are $18,152 higher than in obese peers without binge eating.13 The prevalence of binge eating and the substantial burden of healthcare costs highlight the need for treatments that eliminate binge eating and produce weight loss. Despite this, there is a paucity of interventions that address these comorbid conditions. In this Phase 1 project, we seek to build a digital therapeutic (called OTX-401) that will be ready for testing in a large, multi-site, well-powered clinical trial during Phase 2. Positive results will be the critical initial step to facilitating the widespread implementation and commercialization of the digital therapeutic to enhance access to highly personalized obesity and binge eating intervention.