AST: On Target Cards for Monitoring Superfund Sites

项目摘要 超级基金场地对居住在附近的人的健康构成重大风险，因为它们含有高水平的有毒物质。 这些化学物质会影响当地的水和土壤化学，导致包括肾脏在内的各种疾病。 疾病、癌症和心脏病。目前，超级基金网站名单包括约1400个活动或拟议的网站 在美国有一个持续的需要，以衡量补救的有效性和监测有毒 随着时间的推移，化学水平，以尽量减少对周围人群的风险。重金属是常见的有毒物质 超级基金网站中发现的化学物质。传统的实验室方法能够测量金属， 但需要较长的交货时间（通常是几周）以及较高的仪器和劳动力成本。因此，在本发明中， 测量不经常进行，可能导致意外释放，使周围环境 社区处于危险之中。由于这些问题，使用了几种按需测量技术， 在超级基金地点测量重金属，包括X射线荧光（XRF）和比色测试套件，但 这两种方法都有很大的局限性。该领域，特别是超级基金网站，缺乏简单的传感器 它可以同时测量多种有毒金属，只需最少的用户步骤和相关浓度。 程度.本项目的目标是开发一个多路复用水质监测系统，用于测量有毒物质， 使用Access Sensor Technology的On-Target®卡检测超级基金场地地下水和地表水中的金属 系统On-Target®卡使用专有技术快速轻松地测量水中的金属浓度。 产生直径与浓度成比例的有色圆的比色反应。虽然我们 我在这项技术上取得了重大进展，但它不适用于今天的超级基金现场监测 因为电流检测极限太高（ppm对ppb）并且卡仅检测单一金属， 这意味着用户必须随身携带大量的卡以完成简档。在第一阶段，我们将重点 降低检测限（目标1），创建多重检测（目标2），并开发第一代 数据可视化软件，同时进行初步实地研究（目标3）。林肯公园现场的样本 位于科罗拉多弗里蒙特县（废弃的铀研磨场）的一个试验场将被用于试验。我们的感应系统 根据ICP-MS或AAS进行严格性验证。在第一阶段结束时，我们将成功地建立一个 第二代On-Target®产品原型，可实现浓度的多重金属分析 与我们的客户相关的水平。这一努力将使我们能够在第二阶段进一步发展， 额外的分析物并通过与早期采用者的联系渗透到市场。

Project Summary Superfund sites pose a significant risk to human health for those living nearby as they have high levels of toxic chemicals that can impact the local water and soil chemistry, leading to a myriad of diseases including kidney disease, cancer, and heart disease. Currently the Superfund site list consists of ~1400 active or proposed sites in the United States. There is an on-going need to measure remediation effectiveness and monitor toxic chemical levels over time to minimize the risk to surrounding populations. Heavy metals are common toxic chemicals found in Superfund sites. Traditional laboratory methods are capable of measuring metals but are subject to long lead times (often weeks) as well as high instrumentation and labor costs. As a result, measurements are performed infrequently and can result in unanticipated releases, putting surrounding communities at risk. Because of these problems, several point-of-need measurement technologies are used to measure heavy metals at Superfund sites, including X-Ray Fluorescence (XRF) and colorimetric test kits, but both approaches have significant limitations. The field, and Superfund sites in particular, lack simple sensors that can measure multiple toxic metals simultaneously with minimal user steps and at relevant concentration levels. The goal of this project is to develop a multiplexed water quality monitoring system for measuring toxic metals in ground and surface water at Superfund sites using Access Sensor Technology's On-Target® card system. On-Target® cards quickly and easily measure metal concentrations in water using proprietary colorimetric reactions that generate a colored circle with a diameter proportional to concentration. While we have made significant progress with this technology, it is not applicable to Superfund site monitoring today because current detection limits are too high (ppm versus ppb) and the cards only detect a single metal, meaning users must carry a large number cards with them for complete profiling. During Phase I, we will focus on reducing the detection limits (Aim 1), creating the multiplexed assay (Aim 2), and developing first generation data visualization software while performing initial field studies (Aim 3). Samples from the Lincoln Park site (abandoned Uranium milling site) in Fremont County, Colorado will be used for testing. Our sensing system will be validated against ICP-MS or AAS for rigor. At the end of Phase I, we will have successfully created a prototype second-generation On-Target® product that enables multiplexed metal analysis at concentration levels relevant to our customers. The effort will position us for both further development during Phase II with additional analytes and penetration into the market through connections with early adopters.