New Dynamometric Techniques for Predicting Glaucoma Progression

预测青光眼进展的新测力技术

• 批准号: nhmrc : 458743
• 负责人: Prof Dao-Yi Yu
• 金额: $ 11.46万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Development Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/new-dynamometric-techniques-glaucoma-progression/96780
• 关键词: New; Dynamometric; Techniques; Predicting; Glaucoma

Glaucoma is a major cause of blindness in our community. The biggest risk factor for glaucoma is raised intraocular pressure. However, the exact cause of the disease remains unknown. Through our basic science studies in animals we have discovered that changes in blood flow in the vessels at the optic disk may be involved in the disease process. In recent clinical trials we discovered that the presence or absence of pulsations in the retinal veins at the disk was both an indicator of severity and progression of glaucoma. This is a major breakthrough because there is no other means of predicting in which glaucoma patients vision loss will develop most rapidly. This information will be very helpful in deciding which patients should have the most agressive treatment to restore normal intraocular pressure. This project seeks to develop a new commercial device to make such an examination easy for any clinical ophthalmologist. The device allows the doctor to examine the vessels at the disk whilst applying slight pressure to the eye to temporarily raise intraocular pressure. A footswitch is pressed when the doctor sees the vessels pulsate. The required force is recorded by a laptop computer and the data stored along with the patients details. Now we have confirmed the ability of such a measurement to predict the rate of visual field loss in glaucoma, such a measurement will become much more widespread in clinical ophthalmology, offering a new and large scale opportunity for such instrumentation. Our device will be easy to operate, more comfortable for the patient, and will be of major diagnostic value in glaucoma clinics worldwide.

青光眼是导致失明的主要原因之一。青光眼的最大危险因素是眼内压升高。然而，疾病的确切原因仍然未知。通过对动物的基础科学研究，我们发现视盘血管中的血流变化可能与疾病过程有关。在最近的临床试验中，我们发现视盘处视网膜静脉搏动的存在或不存在是青光眼严重程度和进展的指标。这是一个重大突破，因为没有其他方法可以预测青光眼患者视力丧失的发展最快。这些信息将非常有助于决定哪些患者应该接受最积极的治疗以恢复正常的眼内压。该项目旨在开发一种新的商业设备，使任何临床眼科医生都能轻松进行这种检查。该装置允许医生检查椎间盘处的血管，同时向眼睛施加轻微的压力以暂时升高眼内压。当医生看到血管搏动时，踩下脚踏开关。所需的力由笔记本电脑记录，数据与患者详细信息一起沿着存储。现在我们已经证实了这种测量方法预测青光眼视野丧失率的能力，这种测量方法将在临床眼科学中得到更广泛的应用，为这种仪器提供了一个新的和大规模的机会。我们的设备将易于操作，患者更舒适，并将在全球青光眼诊所的主要诊断价值。