Pathogenic role of changes in the extracellular environment of retinal ganglion cells in glaucoma

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There are an estimated 60 million glaucoma sufferers worldwide. Glaucoma is associated with elevated pressure within the eye but the mechanisms by which this leads to vision loss are not clear. We propose to test a new hypothesis that it is tissue stress that is responsible for the ganglion cell death in glaucoma. We propose to measure key parameters of the cellular environment in an animal model of raised intraocular pressure and determine if elevated intraocular pressure induced changes in the cellular environment can be identified.