Pathogenic role of changes in the extracellular environment of retinal ganglion cells in glaucoma

视网膜神经节细胞胞外环境变化在青光眼中的致病作用

• 批准号: nhmrc : 1027170
• 负责人: Prof Dao-Yi Yu
• 金额: $ 31.47万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/pathogenic-role-changes-cells-glaucoma/110544
• 关键词: Pathogenic; role; changes; extracellular; environment

There are an estimated 60 million glaucoma sufferers worldwide. Glaucoma is associated with elevated pressure within the eye but the mechanisms by which this leads to vision loss are not clear. We propose to test a new hypothesis that it is tissue stress that is responsible for the ganglion cell death in glaucoma. We propose to measure key parameters of the cellular environment in an animal model of raised intraocular pressure and determine if elevated intraocular pressure induced changes in the cellular environment can be identified.

据估计，全球有6000万青光眼患者。青光眼与眼内压力升高有关，但导致视力丧失的机制尚不清楚。我们建议检验一个新的假设，即青光眼中的神经节细胞死亡是由组织应激引起的。我们建议在眼压升高的动物模型中测量细胞环境的关键参数，并确定是否可以识别高眼压引起的细胞环境的变化。