P30-Core Grant for Vision Research Core C

生物统计和生物信息学(生物分析)核心的任务是提供现代生物信息学 和统计方法提供给亚特兰大视力研究社区(AVRC)。《生物分析指南》 核心是向由NEI R01资助的AVRC的主要调查员提供资源(专业知识、工具、 培训和服务)，这通常不是通过个人NEI R01赠款获得的。此外，我们还为 VISION核心赠款的高生产力和协作性成员之间的互动。我们的模块 促进数据存储、管理、检索和管理，并维护安全且已备份的服务器- 基于数据归档来处理大量的生物数据。我们召集了一群信息学家， 开发/实施新工具和服务的计算机程序员/管理员。这些人员执行 数据分析，并指导其他人如何使用这些工具。生物分析核心构成核心的核心 活动从基于数据服务器的数据存储开始，最终进行分析。我们协调努力 使用其他模块带头分析由添加到 Vision Core的研究努力。生物分析核心的具体目标包括： 1.提供比NEI更好的资源和更方便的访问最先进的分析工具- R01PI可单独提供或支持。 2.与私人投资经理协商，以确定项目范围、时间范围和所需服务。 3.开展原本需要雇用生物信息学和生物统计专家的工作，即 对于R01预算来说，这是不切实际的。 4.酌情为绩效指标和人员提供培训，以执行更多的日常任务。 5.对前沿技术的数据和软件进行预测试和故障排除，以避免重复 多个个人PI的错误。

The mission of the Biostatistics and Bioinformatics (Bioanalysis) Core is to provide modern bioinformatics and statistical methods to the Atlanta Vision Research Community (AVRC). The directive for the Bioanalysis Core is to provide NEI R01-funded principal investigators (PIs) in the AVRC, the resources (expertise, tools, training, and services) that are not usually obtained through individual NEI R01 grants. In addition, we facilitate interactions among highly productive and collaborative members of the vision core grant. Our module facilitates data storage, curation, retrieval, and management, and maintaining a secure and backed up, server- based data archive to handle large sets of biological data. We have assembled a group of informaticists and computer programmers/administrators to develop/implement new tools and services. These personnel perform data analyses, and instruct others on the use of these tools. The Bioanalysis Core forms the heart of the core activities beginning with data server-based data storage and eventually analysis. We coordinate our efforts with other modules to lead in the analysis of data generated by each new piece of equipment added to the Vision Core's research endeavor. Specific Aims of the Bioanalysis Core include: 1. Provides better resources and more convenient access to state of the art analysis tools than an NEI- R01 PI could provide or support alone. 2. Consults with PIs to determine scope of a project, timeframe, services needed. 3. Conducts work that would otherwise require hiring of bioinformatics and biostatistics experts that is impractical for an R01 budget. 4. Provides training to PIs and personnel as appropriate for more routine tasks. 5. Pre-tests and troubleshoots data and software from bleeding edge technologies to avoid repeated mistakes by multiple individual PIs.