PDX核心-猫眼课题宝

PDX核心

批准号：

10013164

负责人：

Vito William Rebecca

金额：

$2.0万

依托单位：

WISTAR INSTITUTE

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/10013164

关键词：

Biological Biological Assay Biological Models Cell Line Cells Cellular biology Clinical Collaborations Collagen Communicable Diseases DNA Data Data Storage and Retrieval Databases Disease Ensure Freezing Future Genetic Genetic Fingerprintings Human Immunodeficient Mouse In Vitro Laboratories Lesion Medical Genetics Melanoma Cell Methodology Modeling Molecular Molecular Abnormality Monitor Mus Neoplasm Metastasis Patients Pilot Projects Proteins Quality Control RNA Reproducibility Research Research Personnel Research Project Grants Resources Scientist Seeds Services Skin Testing Training Validation cell bank experimental study in vitro Model in vivo Model investigator training melanoma member neoplastic cell novel therapeutics pathogen preclinical study programs protein expression screening success three-dimensional modeling tool tumor tumor growth

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Project Summary – PDX Core The PDX Core provides major resources to the program investigators, including melanoma PDX, melanoma cell lines and 3D models to explore new therapies. The melanoma PDX encompasses >450 different tumors representing all clinical and genetic groups of the disease. The primary focus of the PDX core is to establish new PDX and coordinate their characterization at the DNA, RNA, and protein levels. It then maintains the master cell bank, monitors for mouse pathogens, and collaborates with other investigators within the program, within the overall PDTC and outside scientists. The Core is also to central facilitator for exchanging PDX within the PDXNet for a coordinated effort on collaborations. The Core coordinates data storage and distribution to other investigators within the Program. The PDX Core is available to train investigators of the Program in all biological assays and models. Overall, this Core will provide efficient and high-quality service to all laboratories within this PDTC. 1

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