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Automated Detection and Classification of Laryngeal Diseases Using Deep Neural Networks

使用深度神经网络自动检测和分类喉部疾病

基本信息

批准号：
10043172
负责人：
Andres Martin Bur
金额：
$ 15.44万
依托单位：
UNIVERSITY OF KANSAS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-10 至 2022-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10043172
关键词：
Aerodigestive Tract Algorithms Anesthesia procedures Appearance Architecture Awareness Benign Caring Categories Cessation of life Classification Clinic Clinical Collaborations Colonic Polyps Colonoscopy Communities Computer Vision Systems Custom Data Set Detection Development Diagnosis Diagnostic Disease Disease Progression Distal Drops Early Diagnosis Educational process of instructing Ensure Fellowship Functional disorder Gastroesophageal reflux disease Goals Health Services Accessibility Hoarseness Image Improve Access Infection Label Laryngeal Diseases Laryngoscopes Laryngoscopy Larynx Learning Lesion Leukoplakia Location Malignant - descriptor Malignant Neoplasms Malignant neoplasm of larynx Manuals Modeling Modernization Morbidity - disease rate Network-based Normal Range Otolaryngologist Otolaryngology Papilloma Pathology Patient Care Patients Performance Pilot Projects Plug-in Polyps Positioning Attribute Procedures Recurrence Resources Sampling Semantics Structure Students Symptoms System Technical Expertise Testing Training Vision research Work base classification algorithm cost deep neural network detector digital experience feature extraction flexibility improved large datasets learning algorithm multidisciplinary network models neural network tool

项目摘要

PROJECT SUMMARY The long-term goal of this project is to improve the care of patients with laryngeal disorders through development of automated diagnostic support for in-office flexible laryngoscopy. To accomplish this goal, we propose developing neural network-based algorithms to detect and classify structural laryngeal lesions in laryngoscopy images. An automated diagnostic tool for in-office laryngoscopy such as we propose will have several benefits: (1) It will improve access to care for patients with symptoms of laryngeal dysfunction living in communities with limited otolaryngology resources, (2) It will improve early detection of laryngeal cancers potentially reducing the morbidity of treatment, and (3) It will prove a valuable teaching tool for students and residents first learning to interpret laryngoscopic exams. Flexible laryngoscopy is a common in-office procedure performed by otolaryngologists to evaluate the upper aerodigestive tract in patients with symptoms of laryngeal dysfunction. Subtle differences in the appearance of laryngeal lesions enable otolaryngologists to differentiate benign lesions from suspected malignant ones. The expertise and clinical acumen to correctly interpret laryngoscopic findings requires years of training and therefore laryngoscopy is largely only performed in subspecialty otolaryngology clinics. The primary objective of this project is to develop neural network-based algorithms to detect and classify structural laryngeal lesions. Our hypothesis is that these algorithms can be trained using a large dataset of laryngeal images to accurately detect and classify structural laryngeal lesions on flexible laryngoscopic exam. To test this hypothesis, we propose the following aims: (1) Generate a dataset of high-quality, labeled endoscopic laryngeal images corresponding to normal and structural lesions of the larynx, (2) Develop a location-aware anchor-based reasoning neural network for accurate detection of laryngeal lesions, and (3) Develop an adaptive network model for classification of structural laryngeal pathologies including papilloma, polyp, leukoplakia and suspected malignancy. With expertise in the diagnosis and treatment of laryngeal disorders and computer vision, including object detection and classification, our multidisciplinary team is uniquely qualified to complete this project.

项目总结