Electrical impedance tomography for the improved assessment of pulmonary function in neuromuscular disease
Electrical impedance tomography for the improved assessment of pulmonary function in neuromuscular disease
批准号:
10042631
负责人:
Ryan Joseph Halter
金额:
$49.53万
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
已结题
起止时间:
2020-07-01 至 2024-05-31
关键词:
ALS patientsAcuteAdultAgeAmbulatory CareAmyotrophic Lateral SclerosisApplications GrantsAssessment toolAtelectasisBreathingCaregiversChestChildhoodChronicChronic CareClinical TrialsConfusionCritical CareDataDiseaseDisease ProgressionElectrodesEnrollmentEvaluationFaceFatigueFrequenciesFunctional disorderFutureGoalsGuillain-Barré SyndromeImageImpairmentInpatientsInstitutionIntensive Care UnitsInterventionIntubationLip structureLungLung diseasesMeasurementMeasuresMedicalMethodsMonitorMuscular DystrophiesMyasthenia GravisNeuromuscular DiseasesOutcomePainlessPatient CarePatientsPopulationPremature InfantPulmonary function testsReadingReproducibilityResearchResolutionRespiratory physiologyRestRiskSelf-Help DevicesSeveritiesSurfaceTechniquesTechnologyTestingTimeWorkacute carebasecomparison groupdata standardselectrical impedance tomographyexpectationexpirationimprovedinsightlung maturationmotor controlpulmonary functionrespiratorysextoolvoltage
中文摘要
项目总结
英文摘要
PROJECT SUMMARY
Respiratory weakness is a common manifestation of many neuromuscular diseases, including
amyotrophic lateral sclerosis (ALS), myasthenia gravis, Guillain-Barre syndrome, and certain muscular
dystrophies. Standard pulmonary function tests (PFTs) suffer from a number of limitations. These include: 1.
inability to obtain accurate data in patients with concomitant bulbar weakness 2. Reliance on the patient being
able to cooperate effectively; 3. Inability to obtain continuous assessment, especially when the patient is in the
intensive care unit; 4. It provides no insight into pulmonary condition, including the presence of atelectasis. One
approach that offers a potential more effective means for monitoring pulmonary function is via the application of
electrical impedance tomography (EIT). In EIT, a belt embedded with multiple surface electrodes is placed
around the chest and a low-resolution image is obtained by passing a very weak, non-ionizing electrical current
between varying sets of electrodes and measuring the resulting voltages. Real-time videos of breathing can be
obtained with the patient at rest breathing comfortably and also with full inspiration and expiration. From these
images, simple metrics of pulmonary function can be derived. The technology has already found use in critical
care patients with a variety of disorders and is very safe, it is even being used in premature infants to help monitor
pulmonary condition and lung maturation. In this R21 proposal, we seek to establish the specific application of
this technology in patients at risk for or with pulmonary dysfunction with ALS since they represent a group in
whom the technology may be especially useful. In specific aim 1, we plan to assess the reliability of the technique
in both ALS patients and age- and sex-matched healthy controls and to determine its relative sensitivity to
pulmonary dysfunction. In specific aim 2, we will determine the relationship between EIT values and standard
pulmonary function parameters both cross-sectionally and longitudinally over an approximately 3-month period
of time, in patients both with and without concomitant bulbar weakness. At the end of this study we hope to have
demonstrated the potential value for EIT the assessment of pulmonary function in ALS, opening the door to its
wide application in the acute and chronic care of patients across a range of neuromuscular diseases.
期刊论文(1)
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科研奖励(0)
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