Classifying Oral Lesions with Chip-on-tip Electrical Impedance Sensing

摘要 在常规检查期间，临床上没有实时定量设备用于评估口腔病变， 临床诊断和纵向监测具有挑战性。相反，通过视觉评估病变 检查，然后对活检期间提取的组织样本进行组织病理学分析。识别 早期的癌前病变和恶性口腔病变对于确保为患者提供有效治疗至关重要 恶性肿瘤口腔癌目前在主要癌症中具有最低的5年生存率（50%或更低）之一。 癌症类型，主要是由于早期识别癌前病变和恶性病变的挑战。显然，A 能够将口腔病变分类为良性、癌前病变或恶性的实时临床设备有可能 对患者护理产生直接影响。显著不同的电特性签名已经被 在包括舌在内的各种器官中的良性和恶性组织之间观察到;由于生物电 特性是如此依赖于组织结构和形态，我们假设，传感和成像 这些性质在口腔病变的背景下将使我们能够准确地表征和分类 形态学上不同的良性、癌前病变和恶性口腔病变。我们发明了一种内窥镜 电阻抗成像（EII）设备用于术中手术切缘评估，我们的目标是 优化临床口腔病变评估。我们的目标是迈出重要的一步， 在阻抗成像方面的经验，以开发可以安全部署的口腔病变成像设备， 诊所，以提供关于口腔病变分类的实时反馈。我们建议写一部小说 尖端芯片EII探针，以接近显微镜分辨率的口腔病变进行感测和成像， 为临床医生提供实时、准确的口腔病变病理分类，可用于诊断和 纵向监测目的。将在一系列体内人类口腔病变上评估探针， 与活检样本的组织病理学分析相比。这种设备的低成本使其成为一种 低资源设置的理想技术以及系统的安全性和实时能力使其成为理想的 用于连续跟踪病变。

ABSTRACT No real-time quantitative devices are clinically used to assess oral lesions during routine examination, making in-clinic diagnostic and longitudinal monitoring challenging. Instead, lesions are evaluated through visual inspection and then histopathological analysis of tissue samples extracted during biopsy. Identifying premalignant and malignant oral lesions early is critical to ensuring effective treatment is provided to patients with malignancies. Oral cancer currently has one of the lowest 5-year survival rates (50% or less) among major cancer types, largely due to the challenges in identifying premalignant and malignant lesions early. Clearly, a real-time in-clinic device able to classify oral lesions as benign, premalignant, or malignant has the potential to provide immediate impact to patient care. Significantly different electrical property signatures have been observed between benign and malignant tissues in a variety of organs, including tongue; since the bioelectrical properties are so dependent on tissue architecture and morphology, we hypothesize that sensing and imaging these properties in the context of oral lesions will enable us to accurately characterize and classify morphologically-different benign, premalignant, and malignant oral lesions. We have developed an endoscopic electrical impedance imaging (EII) device for use in intraoperative surgical margin assessment that we aim to optimize for in-clinic oral lesion assessment. We aim to take the significant step of translating our extensive experience in impedance imaging to develop an oral lesion imaging device that can be deployed safely, and in the clinic, to provide real-time feedback regarding oral lesion classification. We propose constructing a novel chip-on-tip EII probe to sense and image at near microscopic resolution oral lesions in an effort to provide clinicians with real-time, accurate classification of oral lesion pathology that can be used for diagnostic and longitudinal monitoring purposes. The probe will be evaluated on a series of in vivo human oral lesions and compared with histopathological analysis of biopsy samples. The low-cost of a device such as this makes it an ideal technology for low-resource settings and the safety and real-time capabilities of the system make it ideal for continuously following lesions.