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Discovering new genes involved in protective T-cell responses through the generation of mice with targeted mutations

Discovering new genes involved in protective T-cell responses through the generation of mice with targeted mutations
通过培育具有靶向突变的小鼠,发现参与保护性 T 细胞反应的新基因
批准号:
10042745
负责人:
Luis J Sigal
金额:
$23.4万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
已结题
起止时间:
2020-06-01 至 2022-05-31

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英文摘要
Abstract T-cells play major functions to combat infectious diseases and cancer, are critical for the effectiveness of vaccines, and may have negative effects in various types of immune disorders. While many of the genes involved in T-cell responses have been identified, it is likely that many remain unknown. The discovery of these genes and their specific roles during in vivo immune responses could provide major advances in our understanding of the immune system and for the improvement of vaccines and/or treatment of infectious diseases, cancer, and various immune disorders. Here we propose to generate mice with T-cell deletions of genes whose transcription is perturbed in specific T-cell populations during protective anti-viral T-cell responses. Our hypothesis is that some of these genes will play essential roles in immune responses to pathogens and possible in cancer and various immune dysfunctions. The mouse models developed through this grant will provide new valuable information about the role of still little-known genes in the modulation of the anti-viral immune response and resistance to viral infection and may be the basis of future novel discoveries encompassing not only immunology but other areas of mammalian biology.
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Mechanisms of protective memory CD8 T-cell induction by mRNA-LNP vaccines
  • 批准号:
    10753981
  • 项目类别:
  • 资助金额:
    $72.27万
  • 财政年份:
    2023
  • 负责人:
    Luis J Sigal
  • 依托单位:
Discovering new genes involved in monocyte-mediated protective anti-viral innate immunity through the generation of mice with targeted mutations
  • 批准号:
    10303725
  • 项目类别:
  • 资助金额:
    $23.4万
  • 财政年份:
    2021
  • 负责人:
    Luis J Sigal
  • 依托单位:
Discovering new genes involved in monocyte-mediated protective anti-viral innate immunity through the generation of mice with targeted mutations
  • 批准号:
    10416067
  • 项目类别:
  • 资助金额:
    $19.5万
  • 财政年份:
    2021
  • 负责人:
    Luis J Sigal
  • 依托单位:
Natural Killer Cell Deficiencies in Aging Mice
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