Joint Effects and Community-Level Characteristics in Estimating Cerebrovascular Risk Among HIV Infected and Uninfected Veterans

估计艾滋病毒感染者和未感染退伍军人脑血管风险的联合效应和社区水平特征

• 批准号: 10012749
• 负责人: Hirut T Gebrekristos
• 金额: --
• 依托单位: VETERANS HEALTH ADMINISTRATION
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2021-09-10
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10012749
• 关键词: Acute; Affect; Aging; Alcohol abuse; Alcohols; Atrial Fibrillation; Attention; Behavioral; Biological Markers; Brain hemorrhage; Cardiovascular system; Censuses; Cerebral hemisphere hemorrhage; Cerebrovascular Disorders; Characteristics; Clinical; Cohort Studies; Communities; Data; Dependence; Development; Diagnosis; Disease Outcome; Drug abuse; Epidemiology; Ethnic group; Event; Gold; HIV; HIV Seronegativity; HIV Seropositivity; HIV risk; Health; Hepatitis C; Incidence; Individual; Infection; Ischemic Stroke; Joints; Kidney Diseases; Latino; Metabolic Diseases; Methods; Mood Disorders; Neighborhoods; Outcome; Population; Poverty; Predictive Value; Race; Research; Risk; Risk Estimate; Risk Factors; Role; Sampling; Sensitivity and Specificity; Subarachnoid Hemorrhage; Substance Addiction; Substance abuse problem; Surveys; Techniques; Tobacco use; Veterans; Vulnerable Populations; Work; adjudicate; alcohol effect; cerebrovascular; cohort; disorder prevention; disorder risk; health inequalities; improved; indexing; multilevel analysis; public health intervention; racial and ethnic; secondary outcome; segregation; tool; treatment adherence; virtual

The overall objective of this study is to determine the efect of neighborhood-level characteristics along with individual-level joint characteristics on cerebrovascular disease (CeVD) outcomes among HIV positive and negative veterans. The proposed epidemiologic strategy, which has been underutilized in HIV and CeVD research, includes multi-level analyses that incorporate a neighborhood-level characteristic (race and ethnic segregation) along with the joint efects of individual-level characteristics (HIV treatment, mood disorders, alcohol/drug abuse/dependence) in estimating the incidence of CeVD. This will be the frst study to consider neighborhood-level along with the joint efects of individual-level characteristics in HIV and CeVD research.

这项研究的总体目标是确定邻里层面的影响 脑血管疾病的特点及个体层面的关节特点 (CeVD)艾滋病毒阳性和阴性退伍军人的结局。拟议的流行病学 在艾滋病毒和CeVD研究中一直未得到充分利用的战略包括多层次 结合邻里层面特征(种族和民族隔离)的分析 以及个人层面特征(艾滋病毒治疗、情绪障碍、 酒精/药物滥用/依赖)来估计脑血管病的发病率。这将是第一次 邻里层面与个体层面共同作用的研究 HIV和CeVD研究的特点。