Wireless withdrawal detection and monitoring system for neonatal abstinence syndrome.
新生儿戒断综合征无线戒断检测和监测系统。
基本信息
- 批准号:10013069
- 负责人:
- 金额:$ 22.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-01 至 2021-06-30
- 项目状态:已结题
- 来源:
- 关键词:AccelerometerAcousticsAdultAlgorithmsAmbulatory MonitoringAreaBiochemicalBiomechanicsBiometryBiosensing TechniquesBiosensorBirthBloodBody TemperatureBreathingBusinessesCaregiversCaringChestComputersCustomDataData AnalysesData EngineeringDehydrationDetectionDevelopmentDevicesDiagnosisDrug InteractionsEatingElectroencephalographyEventFamilyFundingGalvanic Skin ResponseGuidelinesHeart RateHospital CostsHospitalsHydration statusInfantIntellectual PropertyInterventionInvestigationLength of StayMachine LearningMeasuresMechanicsMedical Care CostsMethodologyMethodsMinorMonitorMotionNeonatalNeonatal Abstinence SyndromeNeonatal Intensive Care UnitsNewborn InfantNursesOpiate AddictionPatient-Focused OutcomesPatientsPatternPediatricsPharmaceutical PreparationsPharmacological TreatmentPhysiologicalPlayProceduresProcessPulse OximetryReportingResearchRiskSeizuresSeveritiesSkinSleepSneezingSubstance Withdrawal SyndromeSweatingSympathetic Nervous SystemSymptomsSystemTemperatureTestingTimeToxic effectTremorUnited States National Institutes of HealthValidationWireless TechnologyWithdrawalarmbasebiophysical propertiescare costscomplex data costexperienceflexibilityhandheld mobile devicehuman subjectimprovedinnovationinterestmachine learning algorithmmicrochipmonitoring devicenanofabricationneonatal careneonateneuromuscular activitynovelopioid exposureopioid withdrawalphase 1 studyphase 2 studyprenatal exposureprinted circuit boardreal time monitoringresponsesensortherapy durationtooltreatment responsetreatment riskwearable devicewearable sensor technology
项目摘要
SPECIFIC AIMS
Neonatal abstinence syndrome (NAS) is an opioid withdrawal syndrome that develops shortly after birth to in
utero-exposed neonates. The cost of NAS is high: newborns with NAS are typically receive care in the Neonatal
Intensive Care Unit (NICU), where the daily cost of care is high. Nearly 22,000 infants are born with NAS each
year at a cost of $1.5 billion. Moreover, medication-based interventions for the treatment of NAS, used in up to
80% of opioid-exposed infants, carry their own risks of toxicity and drug interactions. Despite the medical cost,
high societal impact of NAS, and the risks of treatment, the tools to assess the severity of NAS can be subjective
and suffer from examiner bias. There is an urgent need for innovative new methods to diagnose NAS and
assess the efficacy of responses to treatment.
Flexible, low-cost wearable devices (worn on the skin) that can report measures of systemic biochemical and
biomechanical processes offer a simple and economical solution. In NAS, surges of sympathetic nervous system
activity produce increased heart rate, skin conductance, unstable temperature, and tremor. These manifest in
increased infant sweating, seizures, tremors, unstable body temperature, and more—events that must
continually monitored and assessed by nurses. The unsupervised, objective detection/quantification of the bodily
response of neonates suffering from NAS could drive the development of new, objective scoring tools that can
guide the initiation, intensity, and duration of therapies for NAS. Such tools could significantly reduce medical
costs and improve patient outcomes by reducing patient time in NICU, reducing nurse load, improving outpatient
monitoring, and helping to assist in the optimization of patient treatments. Critically, we believe such a tool may
be able to objectively capture events that may go unnoticed by nurses or while the infant is sleeping (minor
tremors, poor oxygenation, temperature fluctuations, dehydration).
This proposal seeks to develop interlinked, infant-targeted wearable biosensor-systems capable of continuously
monitoring the biochemical to biophysical parameters of opioid-dependent neonates under treatment for NAS.
Our team has outstanding experience in all areas necessary to this investigation. Our business unit has
extensive NIH funded experience in wearable biosensing, in the detection of sympathetic nervous system activity
in opioid withdrawal, pediatrics, business development, and intellectual property. Our academic partners have
broad experience in novel biosensor development.
特定的目标
项目成果
期刊论文数量(0)
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Shiva Sharareh其他文献
Shiva Sharareh的其他文献
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{{ truncateString('Shiva Sharareh', 18)}}的其他基金
Wireless withdrawal detection and monitoring system for neonatal abstinence syndrome.
新生儿戒断综合征无线戒断检测和监测系统。
- 批准号:
10304777 - 财政年份:2020
- 资助金额:
$ 22.5万 - 项目类别:
Wireless withdrawal detection and monitoring system for neonatal abstinence syndrome.
新生儿戒断综合征无线戒断检测和监测系统。
- 批准号:
10661085 - 财政年份:2020
- 资助金额:
$ 22.5万 - 项目类别:
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