Evaluation of the underlying structure of adolescent social attention

青少年社会关注的底层结构评估

• 批准号: 10046860
• 负责人: Mengya Xia
• 金额: $ 42.92万
• 依托单位: UNIVERSITY OF ALABAMA IN TUSCALOOSA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-07 至 2023-08-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10046860
• 关键词: 13 year old; Address; Adolescence; Adolescent; Age; Area; Attention; Behavior; Behavioral; Behavioral Mechanisms; Biological; Biological Factors; Brain; Child; Chronology; Clinical; Clinical Trials; Cognition; Cognitive; Complex; Confusion; Detection; Development; Discrimination; Electroencephalography; Electrophysiology (science); Enrollment; Evaluation; Foundations; Goals; Individual; Individual Differences; Interpersonal Relations; Intervention; Learning; Link; Measurement; Measures; Mental Health; Methodology; Modeling; Morals; Motivation; Nature; Neurodevelopmental Disorder; Outcome; Parents; Pattern; Peer Group; Persons; Population; Preparation; Process; Reporting; Rewards; Sampling; Social Desirability; Social Discrimination; Social Functioning; Social Interaction; Standardization; Stratification; Structure; Subgroup; System; Testing; Visual; Work; autism spectrum disorder; base; behavior measurement; behavioral response; brain behavior; clinical development; cognitive performance; early adolescence; improved; improved outcome; peer; recruit; relating to nervous system; screening; sex; skills; social; social attention; social cognition; social relationships; social structure; visual tracking

PROJECT SUMMARY/ABSTRACT Social attention is foundational for supporting positive social relationships during adolescence, a developmental period in which social interactions with peers becomes increasingly salient and rewarding 1. Both endogenous (i.e., automatic and undirected, as in detection and encoding) and exogenous (i.e., purposeful and directed, as in reasoning and prediction) social attentional skills are required to decode and understand the actions and intentions of other people, However, at conceptual and practical levels, it is unclear if subdomains of endogenous attention, such as visual discrimination, motivation, and coordinated behavior, are distinct features of social attention 2,3. Additionally, the extent of influence by individual differences in more complex sociocognitive abilities and/or biological factors needs to be further explored. Moreover, further delineation of endogenous and exogenous social cognition at brain and behavioral levels will aid in the development of clinical interventions for individuals with known social attention or sociocognitive problems (e.g., children and adolescents with autism spectrum disorder, ASD). The overall objective of the project is to characterize candidate subdomains of social attention that may relate to sociocognitive skills in adolescence. Proposed project scientific goals: (1) To establish whether social attention involves separable endogenous and exogenous subdomains of visual discrimination, coordinated behaviors, motivation using latent structure analysis; (2) To characterize potential subgroups related to individual differences in sociocognitive abilities and biological predictors using latent profile analysis. These goals will be addressed using a battery of tasks targeting different aspects of social attention via classic behavior, electrophysiology (ERP), and eye tracking (ET). A large and diverse sample of 160 healthy adolescents (11-13 years old) will be enrolled and stratified based upon sociocognitive skills (parent-reported during screening and confirmed via in- person assessment). In this way, we anticipate capturing variability in sociocognitive abilities, increasing the likelihood that the conclusions of analyses may be applicable to a wide range of individuals, including adolescents with neurodevelopmental disorders. Additionally, the narrow age range provides the opportunity to disentangle chronological age, sex, and pubertal status as potential biological factors of social attention. These contributions are expected to deepen our conceptualization of social attention by generating a comprehensive characterization of social attention mechanisms during adolescence across multiple units of measurement. Importantly, we will examine both endogenous and exogenous social attention by implementing a creative battery of tasks that will track spontaneous biological and behavioral mechanisms of social attention. This will become increasingly important in preparation for clinical trials involving minimally verbal or nonverbal adolescents (e.g., 50% of the ASD population is nonverbal) that may struggle with tasks that require an explicit behavioral response.

项目总结/摘要 社会关注是支持青少年时期积极社会关系的基础， 发展期，与同龄人的社会互动变得越来越突出和有益1。 既有内源性的（即，自动的和无定向的，如检测和编码）和外源的（即， 有目的和有方向的，如推理和预测）社会注意力技能需要解码和 理解他人的行为和意图，然而，在概念和实践层面， 如果内源性注意力的子领域，如视觉辨别、动机和协调行为， 是社会关注的显著特征2，3.此外，个体差异的影响程度更大， 复杂的社会认知能力和/或生物因素需要进一步探讨。此外，进一步 在大脑和行为水平上描绘内源性和外源性社会认知将有助于 为已知有社会注意力或社会认知问题的个人制定临床干预措施 (e.g.,患有自闭症谱系障碍（ASD）的儿童和青少年。该项目的总体目标是 描述可能与社会认知技能相关的社会注意力的候选子域， 青春期建议的项目科学目标：（1）确定社会关注是否涉及可分离的 视觉辨别的内、外生子领域，协调行为，动机使用 潜在结构分析;（2）表征与个体差异相关的潜在亚组， 社会认知能力和生物预测使用潜在的配置文件分析。这些目标将在 使用一系列任务，通过经典行为，电生理学， (ERP)眼动追踪（Eye Tracking）将对160名健康青少年（11-13岁）进行大样本和多样化样本的研究。 根据社会认知技能入组和分层（筛选期间由父母报告，并通过研究中确认） 人的评价）。通过这种方式，我们期望捕捉社会认知能力的变化，增加 分析结论可能适用于广泛的个人，包括 患有神经发育障碍的青少年此外，狭窄的年龄范围提供了机会， 将实足年龄、性别和青春期状态作为社会关注的潜在生物学因素。这些 的贡献，预计将深化我们的社会关注的概念，通过产生一个全面的 在多个测量单位的青春期社会注意力机制的表征。 重要的是，我们将通过实施一个创造性的 一系列任务，将跟踪社会注意力的自发生物和行为机制。这将 在准备涉及最少语言或非语言的临床试验中变得越来越重要 青少年（例如，50%的ASD人群是非语言的），可能会在需要明确的任务中挣扎。 行为反应