Optimization of Blood Levels of 25(OH)-vitamin D in African Americans
非洲裔美国人血液中 25(OH)-维生素 D 水平的优化
基本信息
- 批准号:10045657
- 负责人:
- 金额:$ 50.72万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-01 至 2023-08-31
- 项目状态:已结题
- 来源:
- 关键词:Adverse effectsAfrican AmericanAnalysis of VarianceAnimalsAntioxidantsBiologicalBiological AvailabilityBiological MarkersBloodChemistryCholecalciferolClinicalClinical TrialsControlled Clinical TrialsCoupledCysteineDataDevelopmentDiabetes MellitusDiseaseDoseDouble-Blind MethodEnsureFastingFutureGC geneGLUT4 geneGenesGlutathioneGoalsGrantHealthHealth HazardsHumanHydroxylationImpairmentIncidenceInflammationInflammatoryIngestionInsulin ResistanceKidney Function TestsLife StyleLinkLiverMeasurableMediatingMediator of activation proteinMedicalMetabolicMetabolismMixed Function OxygenasesModelingMuscleNatural ProductsNutrientObesityOralOutcomeOxidative StressPainPathway interactionsPhysiologicalPlacebo EffectPlacebosPopulationPrediabetes syndromePregnancy TestsPublic HealthRandomizedRandomized Controlled Clinical TrialsRattusRecommendationRegulationRegulator GenesReportingResearch SubjectsRiskSLC2A1 geneSafetySerumStatistical Data InterpretationSupplementationTNF geneTestingTherapeuticTherapeutic EffectTissuesTranslationsUnited States National Center for Health StatisticsUp-RegulationValidationVisitVitamin AVitamin DVitamin D DeficiencyVitamin D supplementationWhole Bloodcapsulechronic painclinical paincostdelta opioid receptordesigndietary supplementsefficacy clinical trialefficacy trialepidemiology studyexperienceglucose metabolismhealth disparityimprovedliver functionliver metabolismmembermouse modelnovelnovel strategiespreclinical studypreventside effectsuccess
项目摘要
Optimization of 25(OH) vitamin D levels in African Americans
Public Health Issue: Low circulating levels of 25(OH) vitamin D (VD) have been correlated with many
adverse health conditions and health disparities in African Americans (AA). Supraphysiological high-dose VD
supplementation is required to eliminate the differences observed in the levels of circulating 25(OH)VD in AA
and white subjects. However, recent studies have questioned the therapeutic effects of high-dose VD
supplementation.
Rationale: Glutathione (GSH) is a major physiological antioxidant. Recent studies report that low levels of
GSH are linked to 25(OH)VD deficiencies in both animal and human studies. Animal studies using ZDF rats
and a mouse model of 25(OH)VD deficiency have shown that, compared to supplementation with VD-alone,
co-supplementation with VD (cholecalciferol) + L-cysteine (LC, a GSH precursor) led to an improvement in
GSH status that resulted in significant increases in circulating levels of 25(OH)VD and reduced oxidative
stress, TNF-α, and insulin resistance (IR).
Approach: AA have reduced levels of glutathione (GSH), as well as a high incidence of insulin resistance (IR)
and inflammatory disorders. This R33 application presents our design for a randomized, double-blind, placebo-
controlled clinical trial to test the hypothesis that supplementation with VD in combination with L-cysteine (a
GSH precursor) is more successful at optimizing the statuses of 25(OH)VD and GSH [biological signatures]
and simultaneously decreasing TNF-α and IR [functional or clinical outcomes], suggesting a better therapeutic
approach compared with supplementation with VD alone in AA subjects.
Impact on Public Health: The successful completion of this R33 clinical trial will have a significant impact on
the design of future efficacy clinical trials examining co-supplementation using a GSH precursor coupled with
lower VD doses to reduce 25(OH)VD deficiency/inadequacy, inflammation, and IR biomarkers. The
development of a safe, low-cost dietary supplement that can improve 25-hydroxy vitamin D status and reduce
insulin resistance and inflammation would provide significant benefits in the treatment of pre-diabetes and
health disparities, including chronic pain, in the African American population.
This application, which is highly responsive to PAR-18-828, will replicate previous human studies and examine
the outcome of biological signatures by combining the natural product L-cysteine with VD to optimize its
supplementation and efficacy.
非洲裔美国人 25(OH) 维生素 D 水平的优化
公共卫生问题:25(OH) 维生素 D (VD) 循环水平低与许多疾病相关
非裔美国人 (AA) 的不良健康状况和健康差异。超生理性高剂量VD
需要补充以消除 AA 中循环 25(OH)VD 水平的差异
和白人主体。然而,最近的研究对高剂量 VD 的治疗效果提出了质疑
补充。
基本原理:谷胱甘肽 (GSH) 是一种主要的生理抗氧化剂。最近的研究报告称,低水平
在动物和人类研究中,GSH 与 25(OH)VD 缺乏有关。使用 ZDF 大鼠的动物研究
25(OH)VD 缺乏的小鼠模型表明,与单独补充 VD 相比,
联合补充 VD(胆钙化醇)+ L-半胱氨酸(LC,GSH 前体)可改善
GSH 状态导致 25(OH)VD 循环水平显着增加并减少氧化
压力、TNF-α 和胰岛素抵抗 (IR)。
方法:AA 会降低谷胱甘肽 (GSH) 水平,并且会增加胰岛素抵抗 (IR) 的发生率
和炎症性疾病。这个 R33 应用程序展示了我们的随机、双盲、安慰剂设计
对照临床试验检验补充 VD 与 L-半胱氨酸(a
GSH 前体)在优化 25(OH)VD 和 GSH [生物特征] 的状态方面更加成功
同时降低 TNF-α 和 IR [功能或临床结果],表明更好的治疗方法
与 AA 受试者中单独补充 VD 相比。
对公众健康的影响:本次R33临床试验的成功完成将对公众健康产生重大影响
未来疗效临床试验的设计,检查使用 GSH 前体与
降低 VD 剂量以减少 25(OH)VD 缺乏/不足、炎症和 IR 生物标志物。这
开发一种安全、低成本的膳食补充剂,可以改善 25-羟基维生素 D 状态并减少
胰岛素抵抗和炎症将为糖尿病前期和糖尿病的治疗提供显着的益处。
非裔美国人的健康差异,包括慢性疼痛。
该应用程序对 PAR-18-828 高度响应,将复制之前的人体研究并检查
通过将天然产物 L-半胱氨酸与 VD 相结合来优化其生物特征的结果
补充和功效。
项目成果
期刊论文数量(0)
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会议论文数量(0)
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Sushil K Jain其他文献
36 - Manganese Supplementation Lowers Vascular Inflammation by Reducing ROS and Cholesterol Levels Via Downregulation of NOX2 and LDLr in Livers of ZDF Rats
- DOI:
10.1016/j.freeradbiomed.2013.10.450 - 发表时间:
2013-11-01 - 期刊:
- 影响因子:
- 作者:
Elodie Burlet;Sushil K Jain - 通讯作者:
Sushil K Jain
Sushil K Jain的其他文献
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{{ truncateString('Sushil K Jain', 18)}}的其他基金
Optimization of Blood Levels of 25(OH)-vitamin D in African Americans
非洲裔美国人血液中 25(OH)-维生素 D 水平的优化
- 批准号:
10685725 - 财政年份:2020
- 资助金额:
$ 50.72万 - 项目类别:
Optimization of Glutathione Levels and Alzheimer Disease Risk in African Americans
优化非裔美国人的谷胱甘肽水平和阿尔茨海默病风险
- 批准号:
10475166 - 财政年份:2020
- 资助金额:
$ 50.72万 - 项目类别:
Optimization of Blood Levels of 25(OH)-vitamin D in African Americans
非洲裔美国人血液中 25(OH)-维生素 D 水平的优化
- 批准号:
10248397 - 财政年份:2020
- 资助金额:
$ 50.72万 - 项目类别:
L-cysteine, PIP3 and Insulin Signaling in Diabetes
糖尿病中的 L-半胱氨酸、PIP3 和胰岛素信号传导
- 批准号:
8629232 - 财政年份:2014
- 资助金额:
$ 50.72万 - 项目类别:
Ketosis, Vascular Inflammation and Its Therapy in Type 1 Diabetic Patients
1型糖尿病患者的酮症、血管炎症及其治疗
- 批准号:
8004532 - 财政年份:2009
- 资助金额:
$ 50.72万 - 项目类别:
Ketosis, Vascular Inflammation and Its Therapy in Type 1 Diabetic Patients
1型糖尿病患者的酮症、血管炎症及其治疗
- 批准号:
7266156 - 财政年份:2007
- 资助金额:
$ 50.72万 - 项目类别:
Ketosis, Vascular Inflammation and Its Therapy in Type 1 Diabetic Patients
1型糖尿病患者的酮症、血管炎症及其治疗
- 批准号:
7500667 - 财政年份:2007
- 资助金额:
$ 50.72万 - 项目类别:
Ketosis, Vascular Inflammation and Its Therapy in Type 1 Diabetic Patients
1型糖尿病患者的酮症、血管炎症及其治疗
- 批准号:
7663095 - 财政年份:2007
- 资助金额:
$ 50.72万 - 项目类别:
Adjuvant Therapy for Vascular Inflammation in Diabetes
糖尿病血管炎症的辅助治疗
- 批准号:
7107286 - 财政年份:2004
- 资助金额:
$ 50.72万 - 项目类别:
Adjuvant Therapy for Vascular Inflammation in Diabetes
糖尿病血管炎症的辅助治疗
- 批准号:
6954114 - 财政年份:2004
- 资助金额:
$ 50.72万 - 项目类别:
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