New insights into mechanisms that coordinate kinase signalling and molecular motors in mitosis: A novel role for the protein scaffold WD-repeat protein 62 (WDR62).

对有丝分裂中协调激酶信号传导和分子马达机制的新见解：蛋白质支架 WD 重复蛋白 62 (WDR62) 的新作用。

• 批准号: nhmrc : 1046032
• 负责人: A/Pr Marie Bogoyevitch
• 金额: $ 35.28万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/new-insights-mechanisms-62-wdr62/111812
• 关键词: New; insights; into; mechanisms; coordinate

Proteins perform all functions within a cell. Commonly, different proteins are assembled into large complexes to carry out processes, such as cell division, with significant implications for human health. Scaffold proteins facilitate the proper assembly of large complexes but are a poorly understood protein class. We will perform molecular analysis of a newly discovered scaffold, WDR62, to define how it drives cell division and reveal how this can be exploited to develop new anti-cancer drugs.

蛋白质在细胞内执行所有功能。通常，不同的蛋白质被组装成大的复合物，以进行细胞分裂等过程，对人类健康具有重要意义。支架蛋白促进大复合物的正确组装，但是一个知之甚少的蛋白质类。我们将对新发现的支架WDR 62进行分子分析，以确定它如何驱动细胞分裂，并揭示如何利用它来开发新的抗癌药物。