Identifying Imaging Biomarkers of Schizophrenia-Risk in Kenya

识别肯尼亚精神分裂症风险的影像生物标志物

• 批准号: 10054014
• 负责人: DANIEL MAMAH
• 金额: $ 33.36万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10054014
• 关键词: 3-Dimensional; Adolescent and Young Adult; Affect; Africa; Africa South of the Sahara; African; Anisotropy; Anterior; Attentional deficit; Behavior assessment; Behavioral Research; Brain; Brain imaging; Clinical; Collaborations; Communication; Control Groups; Country; Data; Developed Countries; Developing Countries; Development; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Early treatment; Functional Magnetic Resonance Imaging; Functional disorder; Future; Healthcare; Hippocampus (Brain); Hospitals; Human; Image; Image Analysis; Individual; Infrastructure; Kenya; Label; Link; Magnetic Resonance Imaging; Mental Depression; Mental disorders; Modality; Multimodal Imaging; Neurobiology; Onset of illness; Outcome; Parietal; Pathologic; Phenotype; Population; Prevention; Psychotic Disorders; Research; Research Infrastructure; Research Personnel; Resources; Rest; Risk; Risk Factors; Role; Scanning; Schizophrenia; Seeds; Slice; Stress; Structure; Symptoms; Testing; Training; United States; Universities; Washington; Work; Youth; base; behavioral phenotyping; brain abnormalities; clinical predictors; clinical risk; cohort; connectome; ethnic difference; experience; frontal lobe; gray matter; high risk; imaging biomarker; imaging capabilities; imaging modality; indicated prevention; knowledge translation; morphometry; neuroimaging; psychotic symptoms; thalamocortical tract; trait; white matter

ABSTRACT Early treatment of schizophrenia (SZ) is linked to better outcomes, and accurately identifying individuals before illness onset holds promise for prevention. This is especially relevant in sub-Saharan Africa, where financial and health care resources for managing psychotic disorders are extremely limited. Our current proposal aims to introduce cutting-edge psychiatric neuroimaging research to Kenya, and involves multi-modal imaging in adolescents and young adults at clinical high risk (CHR) of developing SZ and other psychotic disorders. Assessing clinical risk symptoms in youth has significantly advanced the possibility of indicated prevention of a full-blown psychotic disorder. Through our previous work, we pioneered prodromal behavioral assessments in Africa, and remain the only group in the continent actively investigating this risk population. Our existing studies in Kenya have suggested some behavioral phenotypes may help better identify those individuals who would transition to SZ. Studies in developing countries have also identified potential neuroimaging predictors of psychosis progression, but such studies have not been previously conducted in African populations. In the United States, our group has had longstanding experience with image analyses involving brain structure and connectivity in SZ and other groups. In the current study, we will use our Washington University Human Connectome Project processing pipeline on imaging data to provide a unique opportunity to characterize the pathological substrates of early psychosis in a racially homogenous African cohort. Building on our existing collaborations, our proposal pioneers a new psychiatric research modality in Kenya and builds capacity for future neuroimaging studies in the country (Aim 1). We will study brain morphometry, as well as structural and functional connectivity in CHR and healthy control groups (Aim 2). Additionally, we will investigate the longitudinal stability of brain findings and potential predictors of clinical change (Aim 3). This would expand our understanding of brain neurobiology in psychotic disorders, paving the path for translation of this knowledge to indicated prevention. Our proposal pioneers a new psychiatric research modality in Kenya, and builds capacity for future neuroimaging studies in the country.

摘要 精神分裂症（SZ）的早期治疗与更好的结果有关，并在治疗前准确识别个体。 疾病的发生为预防带来了希望。这在撒哈拉以南非洲尤其重要，那里的金融和 用于管理精神障碍的卫生保健资源极其有限。我们现时的建议旨在 将尖端的精神病学神经影像学研究引入肯尼亚，并涉及多模式成像， 处于发展SZ和其他精神障碍的临床高风险（HST）的青少年和年轻成年人。 评估青年人的临床风险症状，显著提高了指示性预防的可能性。 完全的精神错乱通过我们以前的工作，我们开创了前驱行为评估， 非洲，仍然是非洲大陆唯一一个积极调查这一风险人群的组织。现有研究 研究人员提出，一些行为表型可能有助于更好地识别那些 向SZ过渡。在发展中国家的研究也确定了潜在的神经影像学预测因子， 精神病进展，但这种研究以前没有在非洲人群中进行过。在联合 国家，我们的小组有长期的经验，图像分析涉及大脑结构和 深圳和其他集团的连通性。在目前的研究中，我们将使用我们的华盛顿大学人类 Connectome项目对成像数据的处理管道，以提供一个独特的机会， 在一个种族同质的非洲队列中早期精神病的病理学基础。基于我们现有的 合作，我们的建议开创了一个新的精神病学研究模式在肯尼亚和建设能力，为未来 神经影像学研究（目标1）。我们将研究大脑形态测量学，以及结构和 功能连接性在糖尿病和健康对照组（目标2）。此外，我们将调查 脑结果的纵向稳定性和临床变化的潜在预测因素（目标3）。这将扩大我们的 了解精神障碍的脑神经生物学，为将这一知识转化为 表示预防。我们的建议开创了肯尼亚新的精神病学研究模式，并建立了能力 用于国内未来的神经影像学研究

项目成果

Socio-demographic, economic and mental health problems were risk factors for suicidal ideation among Kenyan students aged 15 plus.

• DOI: 10.1016/j.jad.2022.01.055
• 发表时间: 2022-04-01
• 期刊: JOURNAL OF AFFECTIVE DISORDERS
• 影响因子: 6.6
• 作者: Ndetei, David M.;Mutiso, Victoria N.;Weisz, John R.;Okoth, Consolate A.;Musyimi, Christine;Muia, Esther N.;Osborn, Tom L.;Sourander, Andre;Wasserman, Danuta;Mamah, Daniel
• 通讯作者: Mamah, Daniel

Temperament & Character account for brain functional connectivity at rest: A diathesis-stress model of functional dysregulation in psychosis.

• DOI: 10.1038/s41380-023-02039-6
• 发表时间: 2023-06
• 期刊: MOLECULAR PSYCHIATRY
• 影响因子: 11
• 作者: Zwir, Igor;Arnedo, Javier;Mesa, Alberto;del Val, Coral;de Erausquin, Gabriel A.;Cloninger, C. Robert
• 通讯作者: Cloninger, C. Robert

Longitudinal and cross-sectional validation of the WERCAP screen for assessing psychosis risk and conversion.

• DOI: 10.1016/j.schres.2022.01.031
• 发表时间: 2022-03
• 期刊: SCHIZOPHRENIA RESEARCH
• 影响因子: 4.5
• 作者: Mamah, Daniel;Mutiso, Victoria N.;Ndetei, David M.
• 通讯作者: Ndetei, David M.