Identifying Imaging Biomarkers of Schizophrenia-Risk in Kenya

识别肯尼亚精神分裂症风险的影像生物标志物

• 批准号: 10054014
• 负责人: DANIEL MAMAH
• 金额: $ 33.36万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10054014
• 关键词: 3-Dimensional; Adolescent and Young Adult; Affect; Africa; Africa South of the Sahara; African; Anisotropy; Anterior; Attentional deficit; Behavior assessment; Behavioral Research; Brain; Brain imaging; Clinical; Collaborations; Communication; Control Groups; Country; Data; Developed Countries; Developing Countries; Development; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Early treatment; Functional Magnetic Resonance Imaging; Functional disorder; Future; Healthcare; Hippocampus (Brain); Hospitals; Human; Image; Image Analysis; Individual; Infrastructure; Kenya; Label; Link; Magnetic Resonance Imaging; Mental Depression; Mental disorders; Modality; Multimodal Imaging; Neurobiology; Onset of illness; Outcome; Parietal; Pathologic; Phenotype; Population; Prevention; Psychotic Disorders; Research; Research Infrastructure; Research Personnel; Resources; Rest; Risk; Risk Factors; Role; Scanning; Schizophrenia; Seeds; Slice; Stress; Structure; Symptoms; Testing; Training; United States; Universities; Washington; Work; Youth; base; behavioral phenotyping; brain abnormalities; clinical predictors; clinical risk; cohort; connectome; ethnic difference; experience; frontal lobe; gray matter; high risk; imaging biomarker; imaging capabilities; imaging modality; indicated prevention; knowledge translation; morphometry; neuroimaging; psychotic symptoms; thalamocortical tract; trait; white matter

ABSTRACT Early treatment of schizophrenia (SZ) is linked to better outcomes, and accurately identifying individuals before illness onset holds promise for prevention. This is especially relevant in sub-Saharan Africa, where financial and health care resources for managing psychotic disorders are extremely limited. Our current proposal aims to introduce cutting-edge psychiatric neuroimaging research to Kenya, and involves multi-modal imaging in adolescents and young adults at clinical high risk (CHR) of developing SZ and other psychotic disorders. Assessing clinical risk symptoms in youth has significantly advanced the possibility of indicated prevention of a full-blown psychotic disorder. Through our previous work, we pioneered prodromal behavioral assessments in Africa, and remain the only group in the continent actively investigating this risk population. Our existing studies in Kenya have suggested some behavioral phenotypes may help better identify those individuals who would transition to SZ. Studies in developing countries have also identified potential neuroimaging predictors of psychosis progression, but such studies have not been previously conducted in African populations. In the United States, our group has had longstanding experience with image analyses involving brain structure and connectivity in SZ and other groups. In the current study, we will use our Washington University Human Connectome Project processing pipeline on imaging data to provide a unique opportunity to characterize the pathological substrates of early psychosis in a racially homogenous African cohort. Building on our existing collaborations, our proposal pioneers a new psychiatric research modality in Kenya and builds capacity for future neuroimaging studies in the country (Aim 1). We will study brain morphometry, as well as structural and functional connectivity in CHR and healthy control groups (Aim 2). Additionally, we will investigate the longitudinal stability of brain findings and potential predictors of clinical change (Aim 3). This would expand our understanding of brain neurobiology in psychotic disorders, paving the path for translation of this knowledge to indicated prevention. Our proposal pioneers a new psychiatric research modality in Kenya, and builds capacity for future neuroimaging studies in the country.

抽象的 精神分裂症（SZ）的早期治疗与更好的结果有关，并准确识别个人 疾病发作有望预防。这在撒哈拉以南非洲尤其重要，那里的财务和 用于管理精神病的医疗保健资源极为有限。我们目前的建议旨在 将尖端的精神神经影像学研究引入肯尼亚，并涉及多模式成像 患有SZ和其他精神病患者的临床高风险（CHR）的青少年和年轻人。 评估青年的临床风险症状已显着提高了预防预防的可能性 成熟的精神病。通过以前的工作，我们开创了前驱行为评估 非洲，并且仍然是非洲大陆的唯一群体，正在积极调查这种风险人群。我们现有的研究 在肯尼亚，提出某些行为表型可能有助于更好地识别那些会 过渡到SZ。发展中国家的研究还确定了潜在的神经影像学预测因素 精神病的进展，但此类研究以前尚未在非洲人群中进行。在曼联 国家，我们的小组在涉及大脑结构和的图像分析方面有长期的经验 SZ和其他组的连通性。在当前的研究中，我们将使用华盛顿大学人类 connectome项目处理管道上的成像数据，提供了一个独特的机会来表征 在种族同质的非洲人群中，早期精神病的病理底物。建立我们现有的 合作，我们的提案开拓了肯尼亚的一种新的精神病研究模式，并为未来增强了能力 该国的神经影像学研究（AIM 1）。我们将研究大脑形态计量学，结构和结构和 CHR和健康对照组的功能连通性（AIM 2）。此外，我们将调查 大脑发现的纵向稳定性和临床变化的潜在预测因子（AIM 3）。这将扩大我们的 了解精神病中脑神经生物学的理解，铺平了将这种知识翻译成的道路 指示的预防。我们的提案开创了肯尼亚的新精神病学研究模式，并建立了能力 对于该国未来的神经影像学研究。

项目成果

Socio-demographic, economic and mental health problems were risk factors for suicidal ideation among Kenyan students aged 15 plus.

• DOI: 10.1016/j.jad.2022.01.055
• 发表时间: 2022-04-01
• 期刊: JOURNAL OF AFFECTIVE DISORDERS
• 影响因子: 6.6
• 作者: Ndetei, David M.;Mutiso, Victoria N.;Weisz, John R.;Okoth, Consolate A.;Musyimi, Christine;Muia, Esther N.;Osborn, Tom L.;Sourander, Andre;Wasserman, Danuta;Mamah, Daniel
• 通讯作者: Mamah, Daniel

Longitudinal and cross-sectional validation of the WERCAP screen for assessing psychosis risk and conversion.

• DOI: 10.1016/j.schres.2022.01.031
• 发表时间: 2022-03
• 期刊: SCHIZOPHRENIA RESEARCH
• 影响因子: 4.5
• 作者: Mamah, Daniel;Mutiso, Victoria N.;Ndetei, David M.
• 通讯作者: Ndetei, David M.

Temperament & Character account for brain functional connectivity at rest: A diathesis-stress model of functional dysregulation in psychosis.

• DOI: 10.1038/s41380-023-02039-6
• 发表时间: 2023-06
• 期刊: MOLECULAR PSYCHIATRY
• 影响因子: 11
• 作者: Zwir, Igor;Arnedo, Javier;Mesa, Alberto;del Val, Coral;de Erausquin, Gabriel A.;Cloninger, C. Robert
• 通讯作者: Cloninger, C. Robert