Multi-Task MR Simulation for Abdominal Radiation Treatment Planning

用于腹部放射治疗计划的多任务 MR 模拟

• 批准号: 10053211
• 负责人: Zhaoyang Fan
• 金额: $ 55.67万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2020-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10053211
• 关键词: 3-Dimensional; 4D MRI; Abdomen; Adoption; Agreement; Algorithms; Anatomy; Breathing; Clinical; Consumption; Data; Data Collection; Development; Dose; Effectiveness; Fatty acid glycerol esters; Future; Geometry; Goals; Image; Institution; Interobserver Variability; Magnetic Resonance; Magnetic Resonance Imaging; Malignant neoplasm of abdomen; Malignant neoplasm of pancreas; Manuals; Methods; Modality; Motion; Normal tissue morphology; Organ; Outcome; Patients; Performance; Phase; Planning Techniques; Positioning Attribute; Precision therapeutics; Procedures; Protons; Radiation Dose Unit; Radiation therapy; Research; Risk; Scanning; Site; Solid; Study Subject; Techniques; Testing; Three-Dimensional Image; Time; Tissues; Translations; Variant; Water; Weight; X-Ray Computed Tomography; automated segmentation; base; computerized data processing; contrast imaging; cost; deep learning; density; experience; image reconstruction; improved; interest; multimodality; multitask; novel; prevent; reconstruction; respiratory; segmentation algorithm; simulation; soft tissue; success; treatment planning; tumor

ABSTRACT The accuracy of radiation treatment planning (RTP) heavily influences the effectiveness of external beam radiotherapy (EBRT). Individualized RTP begins with a “simulation”, in which the patient in a treatment position is commonly scanned using computed tomography (CT) to define the treatment target and organs at risk (OARs). When soft-tissue contrast is inadequate to support accurate target and OAR delineation in CT based RTP, conservatively large treatment margins are used to avoid a geometric miss. The crude treatment prevents delivering sufficient radiation dose to the tumor without exceeding the tolerance of surrounding normal tissues. Magnetic resonance (MR) can be used as a simulation platform complementary to CT for improved soft-tissue conspicuity. Yet, such a complicated, costly and tedious multi-modal RTP workflow along with unavoidable systematic MR-CT co-registration errors has limited its applications in EBRT, especially at the abdominal site whereby anatomies are highly mobile. Over the past few years, there is a keen interest in the integration of MR alone into RTP and even the therapy workflow (i.e. MR-guided radiotherapy, MRgRT). The abdomen poses critical challenges to MR simulation. Current MR imaging sequences are suboptimal to produce motion-free images and resolve respiratory motion. MR data processing for abdominal RTP is underdeveloped. Contouring of OARs typically relies on manual, tedious procedures that are time-consuming and variation-prone. In this proposal, we will substantially improve the MR acquisition and multi-organ auto-segmentation, so the potential of MR as a simulation modality can be fully unleashed for abdominal EBRT. Three specific aims will be completed. In Aim 1, we will develop a standalone multi-task MR (MT-MR) sequence dedicated to abdominal MR simulation. In Aim 2, we will optimize multi-organ auto-segmentation based on MT-MR images. In Aim 3, we will assess the performance of MT-MR in the context of pancreatic cancer stereotactic body radiotherapy planning. Successful completion of the project will dramatically improve treatment precision and clinical outcomes, thus further promoting the adoption of radiotherapy in the management of abdominal cancers. Moreover, the developed techniques will open the door to future studies aiming at optimizations in many aspects of radiotherapy.

抽象的 放射治疗计划（RTP）的准确性严重影响外照射的有效性 放射治疗（EBRT）。个性化 RTP 从“模拟”开始，其中患者处于治疗位置 通常使用计算机断层扫描 (CT) 进行扫描，以确定治疗目标和危险器官 (OAR)。 当软组织对比度不足以支持基于 CT 的 RTP 中准确的目标和 OAR 描绘时， 使用保守的大治疗裕度以避免几何失误。粗暴的处理方式可以防止 向肿瘤提供足够的辐射剂量而不超过周围正常组织的耐受性。 磁共振 (MR) 可作为 CT 的补充模拟平台，以改善软组织 引人注目。然而，如此复杂、昂贵且繁琐的多模式 RTP 工作流程以及不可避免的 系统性 MR-CT 配准误差限制了其在 EBRT 中的应用，尤其是在腹部部位 由此解剖结构具有高度的可移动性。过去几年，人们对 MR 的整合产生了浓厚的兴趣。 单独进入 RTP 甚至治疗工作流程（即 MR 引导放疗，MRgRT）。腹部的姿势 MR 模拟面临的严峻挑战。当前的 MR 成像序列对于产生无运动效果不是最佳的 图像并解析呼吸运动。腹部 RTP 的 MR 数据处理尚不发达。轮廓 的 OAR 通常依赖于手动、繁琐的程序，这些程序既耗时又容易发生变化。在这个 建议，我们将大幅改进 MR 采集和多器官自动分割，因此潜力 MR 作为模拟方式可以充分发挥腹部 EBRT 的作用。将完成三个具体目标。 在目标 1 中，我们将开发专用于腹部 MR 模拟的独立多任务 MR (MT-MR) 序列。 在目标 2 中，我们将基于 MT-MR 图像优化多器官自动分割。在目标 3 中，我们将评估 MT-MR 在胰腺癌立体定向放射治疗计划中的表现。成功的 该项目的完成将极大地提高治疗精度和临床结果，从而进一步 促进在腹部癌症治疗中采用放射疗法。此外，已开发的 这些技术将为未来旨在优化放射治疗许多方面的研究打开大门。