2020 Drug Metabolism Gordon Research Conference and Seminar

项目摘要 2020年第50届药物代谢戈登研究会议（GRC）将突出未发表的，尖端的 研究患者作为独特的 个体，而不是群体，作为提供精确治疗的准备步骤。 庆祝过去50年来该领域的进步，重点是 一个基本 要获得的知识的组成部分是对吸收，分布，代谢， 和药物的消除（ADME）性质。2020年的会议将包括一个关于 整合药物代谢科学和大数据，为精准医学提供信息，并庆祝第50届 科学会议将提供关于在周年纪念日讨论的主题的当代最新信息。 第一个药物代谢GRC，如微生物组的药物代谢，药物代谢的机制， 将体外数据外推至体内药物代谢。主题，如膜转运蛋白，技术 如质谱和新的治疗实体，如siRNA为基础的治疗剂未知的， 1971年也将讨论。正如对GRC的预期，所有演示文稿都将包括未发表的数据， 旨在最大限度地提高观众的参与度和讨论度。鼓励与会者提交海报， 在副主席简·肯尼博士组织的海报会议上展出。海报在2小时内被观看 会议的每一天都有一个会议，这为互动提供了充足的时间。周三晚上的会议 将由年轻的研究人员（研究生，博士后实习生和早期职业生涯）进行口头报告 科学家）从提交的海报摘要中选出。会议是合议和非正式的性质， 充分的机会来讨论未发表的研究，使合作的连接，并开发新的想法。 年轻的调查员很容易得到资深调查员的指导， 职业建议讨论计划在一周内。将有一个公开讨论的会议， 在两位早期职业女科学家主持的会议期间，妇女在科学领域面临的挑战。总的来说， 这次会议将为ADME领域的研究人员提供一个机会，让他们听到最前沿的科学， 与同事进行深入讨论，以促进协作、职业发展和学习。

Project Summary The 50th Drug Metabolism Gordon Research Conference (GRC) in 2020 will highlightunpublished, cutting-edge research patients as unique individuals, rather than populations, as a preparatory step to delivering precision therapeutics. that celebrates advances in the field over the past 50 years, with an emphasis on An essential component of the knowledge to be acquired is a clear understanding of the absorption, distribution, metabolism, and elimination (ADME) properties of the drug. The 2020 conference will include a keynote presentation on the integration of drug metabolism science and big data to inform precision medicine, and in celebration of the 50th anniversary the scientific sessions will provide cutting-edge contemporary updates on topics discussed at the first Drug Metabolism GRC, such as drug metabolism by the microbiome, mechanisms of drug metabolism and extrapolation of in vitro data to drug metabolism in vivo. Topics, such as membrane transporters, technologies like mass spectrometry and novel therapeutics entities, such as siRNA-based therapeutic agents unknown in 1971 will also be discussed. As expected for GRCs all presentations will include unpublished data, with sessions designed for maximal audience participation and discussion. Attendees are encouraged to submit posters for display at the poster sessions organized by the Vice Chair Dr. Jane Kenny. Posters are viewed during a 2-hour session every day of the conference which provides ample time for interaction. The Wednesday evening session will feature oral presentations by young investigators (graduate students, postdoctoral trainees and early career scientists) selected from the submitted poster abstracts. The conference is collegial and informal in nature, with ample opportunity to discuss unpublished research, make collaborative connections, and develop new ideas. Young investigators have easy access to mentoring from established investigators, as well as during informal career advice discussions planned during the week. There will be a session featuring an open discussion of challenges faced by women in science during the meeting led by two early career women scientists. Overall, the meeting will provide an opportunity for researchers in the ADME field to hear cutting edge science and have in depth discussions with colleagues that will facilitate collaboration, career development and learning.