FASEB's "The Steroid Hormones and Receptors in Health and Disease Conference - Jointly hosted by FASEB and the International Committee on Rapid Responses to Steroid Hormones (RRSH)"

FASEB 的“健康和疾病中的类固醇激素和受体会议 - 由 FASEB 和国际类固醇激素快速反应委员会 (RRSH) 联合主办”

• 批准号: 10063235
• 负责人: Daniel Edward Frigo
• 金额: $ 1.75万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-21 至 2021-07-20
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10063235
• 关键词: Adopted; Animal Model; Area; Automobile Driving; Biological Models; Biological Process; Cancer Biology; Cell Nucleus; Cell physiology; Collaborations; Communities; Complex; Consensus; Cytosol; Data; Disease; Endocrine; Endocrine system; Endocrinology; Ensure; Faculty; Financial Support; Fostering; Funding; Gene Expression Regulation; Genetic Transcription; Genomics; Health; Human; Hypothyroidism; Individual; International; Joints; Knowledge; Lead; Ligands; Mediating; Membrane; Metabolism; Neuroendocrinology; Nuclear; Osteoporosis; Paper; Participant; Pathologic; Physiological; Physiology; Postdoctoral Fellow; Process; Proteins; Publishing; Receptor Signaling; Research; Research Personnel; Role; Scientist; Second Messenger Systems; Series; Services; Signal Pathway; Signal Transduction; Structure; Surface; System; Testing; Thinking; Time; Work; base; career; career development; faculty mentor; graduate student; hormonal signals; innovation; insight; interest; meetings; member; non-genomic; novel; peer; posters; professor; receptor; receptor function; response; steroid hormone; steroid hormone receptor; symposium; transcription factor; unpublished works

PROJECT SUMMARY/ABSTRACT Historically, research in the field of steroid hormone signaling has been primarily focused on the transcriptional effects mediated by steroid hormone receptors (SHRs) acting within the nuclei of cells. It is now recognized that the same nuclear SHRs that trigger changes in cellular physiology through the regulation of gene expression can be post-translationally modified and subsequently localized to the cytosol and/or surface membrane to mobilize a variety of intracellular signaling pathways. In addition, new SHRs that function solely outside the nucleus have been identified. These extranuclear effects of SHRs regulate a myriad of biological processes relevant to human health and disease. SHRs rarely act in isolation, but rather synchronize cytoplasmic and nuclear signaling pathways via complex networks of interacting molecules that serve to optimize physiological endocrine functions. Conversely, dysfunctional endocrine systems have a profound impact on health and can lead to various disease states. Not surprisingly, the field has rapidly expanded, such that hundreds of scientific papers are published on the topic each year. Thus, to better understand the myriad of SHR-regulated signaling pathways and their physiological and pathological impact, it is essential to bring together researchers across the field of endocrinology to disseminate new findings, generate novel hypotheses, find consensus on current issues and best approaches, and uncover new and/or unifying themes. To do so, the members of the FASEB scientific research group “Rapid Signaling and Genomic Steroid Hormone Actions in Health & Disease" will come together for the first time to with the participants of the international “Rapid Responses to Steroid Hormones” (RRSH) to explore emerging data regarding the integration of nuclear and extranuclear SHR function. The title of this joint conference is “The Rapid Signaling and Genomic Steroid Hormone Actions in Health and Disease.” The major aims of this conference are to (1) highlight recent research discoveries in the context of integrated SHR actions relevant to health and disease (2) promote the career development of emerging scientists and trainees to ensure the continued vibrancy of the field and (3) further existing research interactions to foster new partnerships that will advance knowledge and foster innovation.

项目摘要/摘要 从历史上看，类固醇骑马信号领域的研究主要集中在转录上 作用在细胞核内作用的类固醇马酮受体（SHR）介导的效果。现在认识到 通过调节基因表达引发细胞生理变化的相同核SHR 可以在翻译后修饰，然后将其定位于细胞质和/或表面膜到 动员各种细胞内信号通路。此外，仅在外面运行的新SHR 已经鉴定出细胞核。 SHR的这些核外影响调节了无数的生物学过程 与人类健康和疾病有关。 SHR很少孤立地起作用，而是同步的细胞质和 通过复杂的相互作用分子网络来优化生理的核信号通路 内分泌功能。相反，功能失调的内分泌系统对健康有深远的影响，可以 导致各种疾病状态。毫不奇怪，该领域已经迅速扩展，因此数百个科学 论文每年就该主题发表。这是为了更好地理解无数的SHR调节信号传导 途径及其身体和病理影响，必须将研究人员融合在一起 内分泌学领域传播新发现，产生新的假设，在当前问题上找到共识 以及最佳方法，并发现新的和/或统一主题。为此，FaseB科学的成员 研究小组“健康与疾病中的快速信号传导和基因组类固醇激素的作用”将汇聚在一起 首次与国际“对类固醇激素快速反应”的参与者（rrsh） 探索有关核和核外SHR功能整合的新兴数据。这个联合的标题 会议是“健康和疾病中的快速信号传导和基因组类固醇激素的作用”。专业 这次会议的目的是（1）在综合SHR行动的背景下强调最新的研究发现 与健康与疾病有关（2）促进新兴科学家和学员的职业发展，以确保 该领域的持续活力和（3）进一步的现有研究互动，以促进新的合作伙伴关系 将促进知识和促进创新。