FASEB's "The Steroid Hormones and Receptors in Health and Disease Conference - Jointly hosted by FASEB and the International Committee on Rapid Responses to Steroid Hormones (RRSH)"

FASEB 的“健康和疾病中的类固醇激素和受体会议 - 由 FASEB 和国际类固醇激素快速反应委员会 (RRSH) 联合主办”

• 批准号: 10063235
• 负责人: Daniel Edward Frigo
• 金额: $ 1.75万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-21 至 2021-07-20
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10063235
• 关键词: Adopted; Animal Model; Area; Automobile Driving; Biological Models; Biological Process; Cancer Biology; Cell Nucleus; Cell physiology; Collaborations; Communities; Complex; Consensus; Cytosol; Data; Disease; Endocrine; Endocrine system; Endocrinology; Ensure; Faculty; Financial Support; Fostering; Funding; Gene Expression Regulation; Genetic Transcription; Genomics; Health; Human; Hypothyroidism; Individual; International; Joints; Knowledge; Lead; Ligands; Mediating; Membrane; Metabolism; Neuroendocrinology; Nuclear; Osteoporosis; Paper; Participant; Pathologic; Physiological; Physiology; Postdoctoral Fellow; Process; Proteins; Publishing; Receptor Signaling; Research; Research Personnel; Role; Scientist; Second Messenger Systems; Series; Services; Signal Pathway; Signal Transduction; Structure; Surface; System; Testing; Thinking; Time; Work; base; career; career development; faculty mentor; graduate student; hormonal signals; innovation; insight; interest; meetings; member; non-genomic; novel; peer; posters; professor; receptor; receptor function; response; steroid hormone; steroid hormone receptor; symposium; transcription factor; unpublished works

PROJECT SUMMARY/ABSTRACT Historically, research in the field of steroid hormone signaling has been primarily focused on the transcriptional effects mediated by steroid hormone receptors (SHRs) acting within the nuclei of cells. It is now recognized that the same nuclear SHRs that trigger changes in cellular physiology through the regulation of gene expression can be post-translationally modified and subsequently localized to the cytosol and/or surface membrane to mobilize a variety of intracellular signaling pathways. In addition, new SHRs that function solely outside the nucleus have been identified. These extranuclear effects of SHRs regulate a myriad of biological processes relevant to human health and disease. SHRs rarely act in isolation, but rather synchronize cytoplasmic and nuclear signaling pathways via complex networks of interacting molecules that serve to optimize physiological endocrine functions. Conversely, dysfunctional endocrine systems have a profound impact on health and can lead to various disease states. Not surprisingly, the field has rapidly expanded, such that hundreds of scientific papers are published on the topic each year. Thus, to better understand the myriad of SHR-regulated signaling pathways and their physiological and pathological impact, it is essential to bring together researchers across the field of endocrinology to disseminate new findings, generate novel hypotheses, find consensus on current issues and best approaches, and uncover new and/or unifying themes. To do so, the members of the FASEB scientific research group “Rapid Signaling and Genomic Steroid Hormone Actions in Health & Disease" will come together for the first time to with the participants of the international “Rapid Responses to Steroid Hormones” (RRSH) to explore emerging data regarding the integration of nuclear and extranuclear SHR function. The title of this joint conference is “The Rapid Signaling and Genomic Steroid Hormone Actions in Health and Disease.” The major aims of this conference are to (1) highlight recent research discoveries in the context of integrated SHR actions relevant to health and disease (2) promote the career development of emerging scientists and trainees to ensure the continued vibrancy of the field and (3) further existing research interactions to foster new partnerships that will advance knowledge and foster innovation.

项目摘要/摘要 从历史上看，类固醇激素信号传导领域的研究主要集中在转录水平。 作用于细胞核内的类固醇激素受体(SHR)所介导的效应。现在人们认识到， 同样的核SHR通过基因表达的调节触发细胞生理的变化 可经翻译后修饰并随后定位于胞浆和/或表面膜以 调动多种细胞内信号通路。此外，仅在外部运行的新SR 已经确定了原子核。SHR的这些核外效应调节着无数的生物过程。 与人类健康和疾病相关。SHR很少孤立地活动，而是同步细胞质和 通过复杂的相互作用分子网络的核信号通路，有助于优化生理 内分泌功能。相反，功能失调的内分泌系统会对健康产生深远的影响，并可能 导致各种疾病状态。毫不奇怪，这一领域迅速扩大，以至于数百名科学家 每年都会发表关于这个主题的论文。因此，为了更好地了解SHR调节的无数信号 途径及其生理和病理影响，至关重要的是将研究人员聚集在一起 内分泌学领域传播新发现，产生新假设，就当前问题达成共识 和最佳方法，并发现新的和/或统一的主题。为了做到这一点，FASEB的成员们科学地 《快速信号与基因组类固醇激素在健康与疾病中的作用》课题组将联合起来 首次与国际“对类固醇激素的快速反应”(RRSH)的参与者一起 探索有关核和核外SHR功能整合的新数据。这个关节的头衔 会议主题是“健康和疾病中的快速信号和基因组类固醇激素作用”。少校 本次会议的目的是(1)在自发性高血压综合行动的背景下突出最新的研究发现 与健康和疾病有关(2)促进新兴科学家和受训人员的职业发展，以确保 该领域的持续活力和(3)进一步现有的研究互动，以培养新的伙伴关系， 将促进知识进步和促进创新。