FASEB's "The Steroid Hormones and Receptors in Health and Disease Conference - Jointly hosted by FASEB and the International Committee on Rapid Responses to Steroid Hormones (RRSH)"

项目总结/摘要 从历史上看，类固醇激素信号传导领域的研究主要集中在转录调控上。 由类固醇激素受体（SHR）介导的作用在细胞核内起作用。现在认识到 同样的核SHR通过基因表达的调节触发细胞生理学的变化 可以被后修饰并随后定位于胞质溶胶和/或表面膜， 调动多种细胞内信号通路。此外，新的SHR，功能完全以外的 核已经被确认。SHR的这些核内效应调节着无数的生物过程 与人类健康和疾病有关。SHR很少单独起作用，而是使细胞质和细胞外的信号同步。 通过相互作用分子的复杂网络的核信号传导途径， 内分泌功能相反，功能失调的内分泌系统对健康有深远的影响， 导致各种疾病状态。毫不奇怪，该领域迅速扩大，数百名科学家 每年都发表关于这一专题的论文。因此，为了更好地理解SHR调节的无数信号传导， 途径及其生理和病理影响，必须将研究人员聚集在一起， 内分泌学领域传播新的发现，产生新的假设，就当前问题达成共识 和最佳方法，并发现新的和/或统一的主题。为此，FASEB的科学家们 研究小组“快速信号和基因组类固醇激素在健康和疾病中的作用”将聚集在一起 第一次与国际“类固醇激素快速反应”（RRSH）的参与者， 探索新出现的数据，关于整合的核和间核SHR的功能。这个地方的名字 会议是“快速信号和基因组类固醇激素在健康和疾病中的作用”。主要 本次会议的目的是（1）强调在综合SHR行动背景下的最新研究发现 （2）促进新兴科学家和受训人员的职业发展， 该领域的持续活力;（3）进一步加强现有的研究互动，以促进新的伙伴关系， 将促进知识和创新。

PROJECT SUMMARY/ABSTRACT Historically, research in the field of steroid hormone signaling has been primarily focused on the transcriptional effects mediated by steroid hormone receptors (SHRs) acting within the nuclei of cells. It is now recognized that the same nuclear SHRs that trigger changes in cellular physiology through the regulation of gene expression can be post-translationally modified and subsequently localized to the cytosol and/or surface membrane to mobilize a variety of intracellular signaling pathways. In addition, new SHRs that function solely outside the nucleus have been identified. These extranuclear effects of SHRs regulate a myriad of biological processes relevant to human health and disease. SHRs rarely act in isolation, but rather synchronize cytoplasmic and nuclear signaling pathways via complex networks of interacting molecules that serve to optimize physiological endocrine functions. Conversely, dysfunctional endocrine systems have a profound impact on health and can lead to various disease states. Not surprisingly, the field has rapidly expanded, such that hundreds of scientific papers are published on the topic each year. Thus, to better understand the myriad of SHR-regulated signaling pathways and their physiological and pathological impact, it is essential to bring together researchers across the field of endocrinology to disseminate new findings, generate novel hypotheses, find consensus on current issues and best approaches, and uncover new and/or unifying themes. To do so, the members of the FASEB scientific research group “Rapid Signaling and Genomic Steroid Hormone Actions in Health & Disease" will come together for the first time to with the participants of the international “Rapid Responses to Steroid Hormones” (RRSH) to explore emerging data regarding the integration of nuclear and extranuclear SHR function. The title of this joint conference is “The Rapid Signaling and Genomic Steroid Hormone Actions in Health and Disease.” The major aims of this conference are to (1) highlight recent research discoveries in the context of integrated SHR actions relevant to health and disease (2) promote the career development of emerging scientists and trainees to ensure the continued vibrancy of the field and (3) further existing research interactions to foster new partnerships that will advance knowledge and foster innovation.