Preventing Vascular Complications in Type 1 Diabetes: Muscle Metabolic Monitoring

预防 1 型糖尿病的血管并发症：肌肉代谢监测

• 批准号: 10022325
• 负责人: Kevin K. McCully
• 金额: $ 67.05万
• 依托单位: INFRARED RX, INC.
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-18 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10022325
• 关键词: Adoption; Algorithmic Analysis; Blood Vessels; Blood flow; Cardiovascular system; Clinical; Clinical Pathways; Clinical Research; Communities; Computer software; Congestive Heart Failure; Consumption; Coronary Arteriosclerosis; Data; Data Analyses; Devices; Diagnosis; Disease; Elderly; Elements; Equipment; Exercise; Future; Goals; Health; Health Status; Hyperglycemia; Impairment; Industry; Insulin; Insulin-Dependent Diabetes Mellitus; Kinetics; Laboratory Research; Marketing; Measurement; Measures; Metabolic; Methodology; Microcirculation; Mitochondria; Modality; Monitor; Morbidity - disease rate; Muscle; Muscle Mitochondria; Muscle function; Near-Infrared Spectroscopy; Oxygen; Panthera leo; Pathway interactions; Patients; Peripheral arterial disease; Pharmacology; Phase; Physiology; Population; Population Heterogeneity; Process; Research; Risk; Skeletal Muscle; Small Business Technology Transfer Research; Surveys; Technical Expertise; Technology; Testing; Time; Universities; automated analysis; base; claudication; cohort; cost; data acquisition; diabetic; exercise training; functional status; improved; insight; interest; mitochondrial dysfunction; mortality; muscle metabolism; muscle physiology; prevent; programs; prototype; sedentary; software development; success; symptomatic improvement; tool; treatment program; validation studies; young adult

Preventing Vascular Complications in Type 1 Diabetes: Muscle Metabolic Monitoring Abstract Measurements of muscle metabolism and blood flow using near infrared spectroscopy (NIRS) have progressively increased, as has the number of companies selling NIRS-based devices. This technology represents the present and future modality for non-invasively characterizing normal and abnormal muscle physiology in health as well as in common, disabling conditions such as Type 1 diabetes (T1D). There is evidence that for people with T1D, health and functional status can be related to impaired microcirculation and muscle mitochondrial dysfunction. In addition, exercise training or other treatment programs to improve symptoms could be evaluated using NIRS-based measurements. Presently, however, there is a lack of commercially available options for obtaining these valuable measurements in clinical settings where they would have the greatest impact. Pilot data from the Exercise Muscle Physiology Lab at the University of Georgia demonstrates both the clinical and research need for this NIRS-based platform, while revealing an important opportunity to commercialize the technology. Our Phase I proposal demonstrated success in evaluating younger adults with T1D, produced working prototypes for the NIRS data analysis program, and developed our initial marketing survey. Our technology is able to yield non-invasively a “vital sign” measure of mitochondrial function in this population that could potentially be used to determine risk or to make a clinical decision. In order to achieve the clinical and commercial potential, start up support is needed to refine processes of setting up, performing, and analyzing measurements of muscle metabolism and blood flow on a wide-scale basis. To affirm the applicability of this technology in a broader, cohort, in Phase II we will apply this technology to evaluate older adults with T1D. We will scale our discoveries into a commercially viable product of value to both the research and clinical communities by refining our automated analysis platform for NIRS-derived measures of skeletal muscle mitochondrial capacity. We will streamline data acquisition such that novice users can at low cost obtain reliable and consistent NIRS-derived measurements of muscle mitochondrial function. Finally, we will develop a pathway for accessing a clinical market by a) focused research on the clinical market best suited for our technology and b) pursuit of the regulatory steps required to access these markets.

预防1型糖尿病的血管并发症：肌肉代谢监测 抽象的 使用近红外光谱法（NIR）测量肌肉代谢和血流 逐渐增加，销售基于NIRS的设备的公司数量也是如此。这项技术 代表当前和未来的方式，用于非侵入性表征正常和异常肌肉 健康和常见的残疾疾病（例如1型糖尿病）（T1D）的生理学。有证据 对于患有T1D的人，健康和功能状态可能与微循环和肌肉受损有关 线粒体功能障碍。此外，运动训练或其他治疗计划以改善症状 使用基于NIRS的测量值进行评估。但是，目前缺乏市售的 在临床环境中获得这些有价值的测量的选项，它们将拥有最大 影响。佐治亚大学运动肌肉生理实验室的试验数据证明了这两种 这个基于NIRS的平台的临床和研究需求，同时揭示了一个重要的机会 商业化技术。我提出的阶段成功地评估了年轻人 T1D，为NIRS数据分析程序生产了工作原型，并开发了我们的初始营销 民意调查。我们的技术能够在这方面产生非侵入性的“生命体征”度量 可能被用来确定风险或做出临床决定的人群。为了实现 临床和商业潜力，需要启动支持才能完善建立，执行和 在广泛的基础上分析肌肉代谢和血流的测量。确认适用性 在第二阶段，我们将在更广泛的，更广泛的队列中使用这项技术来评估老年人 T1D。我们将把发现扩展到商业上可行的产品，以研究和临床的价值。 通过完善我们的自动分析平台，用于NIRS衍生的骨骼肌肉测量平台 线粒体能力。我们将简化数据获取，以便新颖的用户可以低成本获得可靠的 以及肌肉线粒体功能的NIRS衍生的一致测量。最后，我们将发展一个 通过a）对最适合我们的临床市场的重点研究来进入临床市场的途径 技术和b）追求进入这些市场所需的监管步骤。

项目成果

Mitochondrial capacity using NIRS and incomplete recovery curves: Proximal and Medial Vastus Lateralis muscle.

使用 NIRS 和不完全恢复曲线的线粒体容量：近端和内侧股外侧肌。

• DOI: 10.1117/12.2546051
• 发表时间: 2020
• 期刊: Proceedings of SPIE--the International Society for Optical Engineering
• 作者: McCully,KevinK;Liebowitz,Zachary;Sumner,MaxwellD;Beard,Samuel
• 通讯作者: Beard,Samuel

MUSCLE MITOCHONDRIAL CAPACITY AND ENDURANCE IN ADULTS WITH TYPE 1 DIABETES.

1 型糖尿病成人的肌肉线粒体能力和耐力。

• DOI: 10.18103/mra.v8i2.2049
• 发表时间: 2020
• 期刊: Medical research archives
• 作者: Hewgley,RileyA;Moore,BethanyT;Willingham,TBradley;Jenkins,NathanT;McCully,KevinK
• 通讯作者: McCully,KevinK