Mechanisms for synaptic localization of ionotropic GABA receptors in the brain

大脑中离子型 GABA 受体突触定位的机制

基本信息

  • 批准号:
    10056230
  • 负责人:
  • 金额:
    $ 41.88万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2017
  • 资助国家:
    美国
  • 起止时间:
    2017-12-15 至 2022-11-30
  • 项目状态:
    已结题

项目摘要

The activation of neurotransmitter receptors at synapses mediate synaptic transmission upon being bound by neurotransmitters released from presynaptic terminals. The predominant inhibitory transmitter in the brain is gamma-aminobutyric acid (GABA), and ionotropic GABAA receptors localize at inhibitory synapses to mediate fast inhibitory transmission. Dysregulation of GABA receptors causes various mental and neurological disorders including autism spectrum disorder, schizophrenia, epilepsy, and other disorders. However, precise mechanisms for synaptic localization of GABAA receptors remain unclear. We have recently identified novel GARLH family proteins as a critical regulator of synaptic GABAARs. In this proposal, we aim to reveal in vivo roles of GARLHs in regulating GABAAR activity in the brain, principle rules of GARLH-GABAAR interactions, and molecular relationships of constituents of inhibitory synapses. Successful completion of this proposed work will reveal fundamental molecular mechanisms for determining synaptic localization and transmission of GABAA receptors in the brain. Elucidating the molecular rules governing inhibitory transmission will enable us to identify putative molecular targets for drugs that may alleviate impair neurological and mental disorders.
突触神经递质受体的激活介导突触传递

项目成果

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专利数量(0)

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Susumu Tomita其他文献

Susumu Tomita的其他文献

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{{ truncateString('Susumu Tomita', 18)}}的其他基金

Mechanisms for synaptic localization of ionotropic GABA receptors in the brain
大脑中离子型 GABA 受体突触定位的机制
  • 批准号:
    10292976
  • 财政年份:
    2017
  • 资助金额:
    $ 41.88万
  • 项目类别:
Identify functional modulators of ionotropic neurotransmitter receptors in brain
识别大脑中离子型神经递质受体的功能调节剂
  • 批准号:
    8898225
  • 财政年份:
    2014
  • 资助金额:
    $ 41.88万
  • 项目类别:
Identify functional modulators of ionotropic neurotransmitter receptors in brain
识别大脑中离子型神经递质受体的功能调节剂
  • 批准号:
    8784084
  • 财政年份:
    2014
  • 资助金额:
    $ 41.88万
  • 项目类别:
Mechanism for Regulating Kainate-Type Glutamate Receptor Activity
红藻氨酸型谷氨酸受体活性调节机制
  • 批准号:
    8389679
  • 财政年份:
    2009
  • 资助金额:
    $ 41.88万
  • 项目类别:
Genome wide screening of transmembrane accessory subunits of ion channels
离子通道跨膜辅助亚基的全基因组筛选
  • 批准号:
    7830054
  • 财政年份:
    2009
  • 资助金额:
    $ 41.88万
  • 项目类别:
Mechanism for Regulating Kainate-Type Glutamate Receptor Activity
红藻氨酸型谷氨酸受体活性调节机制
  • 批准号:
    8585882
  • 财政年份:
    2009
  • 资助金额:
    $ 41.88万
  • 项目类别:
Mechanism for Regulating Kainate-Type Glutamate Receptor Activity
红藻氨酸型谷氨酸受体活性调节机制
  • 批准号:
    7781584
  • 财政年份:
    2009
  • 资助金额:
    $ 41.88万
  • 项目类别:
Mechanism for Regulating Kainate-Type Glutamate Receptor Activity
红藻氨酸型谷氨酸受体活性调节机制
  • 批准号:
    7995495
  • 财政年份:
    2009
  • 资助金额:
    $ 41.88万
  • 项目类别:
Mechanism for Regulating Kainate-Type Glutamate Receptor Activity
红藻氨酸型谷氨酸受体活性调节机制
  • 批准号:
    8197636
  • 财政年份:
    2009
  • 资助金额:
    $ 41.88万
  • 项目类别:
Genome wide screening of transmembrane accessory subunits of ion channels
离子通道跨膜辅助亚基的全基因组筛选
  • 批准号:
    7938595
  • 财政年份:
    2009
  • 资助金额:
    $ 41.88万
  • 项目类别:

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