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The role of CMTR2 in Lung Cancer

CMTR2在肺癌中的作用

基本信息

批准号：
10059176
负责人：
Alena Yermalovich
金额：
$ 9.53万
依托单位：
DANA-FARBER CANCER INST
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-21 至 2022-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10059176
关键词：
Address Affect Alleles Binding Biogenesis Breast Cancer Biology Career Choice Cell physiology Cells Child Childhood Colon Communities Development Developmental Biology Diagnosis Disease Embryo Engineering Environment Equilibrium Exonuclease Exposure to Family Gene Expression Genes Genetic Goals Hospitals Human Immunohistochemistry In Vitro Kidney Knock-out Laboratories Laboratory Research LacZ Genes Lead Learning Liver Maintenance Malignant Childhood Neoplasm Malignant Neoplasms Malignant childhood renal neoplasm Malignant neoplasm of lung Mentors Messenger RNA MicroRNAs Molecular Mus Mutation Nephroblastoma Neuroblastoma North America Pathogenesis Pathology Pathway interactions Pattern Perlman syndrome Phenocopy Play Positioning Attribute Prevention Prognosis Property Proteins RNA RNA-Binding Proteins Reporter Genes Research Research Project Grants Role Testing Therapeutic Training Translating Translational Research Tumor Suppressor Proteins Universities Vertebrates Work base cancer therapy conditional mutant embryo tissue exome sequencing insight interest leukemia loss of function mutation mouse model nephrogenesis novel nuclease overexpression paralogous gene post-doctoral training precursor cell professor progenitor research facility self-renewal stem cells tenure track transcriptome sequencing tumor tumorigenesis

项目摘要

Project Summary Lin28 is a highly conserved RNA binding protein that modifies gene expression via direct binding of mRNAs and by blocking the processing of the let-7 family of tumor suppressor microRNAs. In vertebrates, Lin28a and its paralog Lin28b are highly expressed in stem and progenitor cells of the early embryo, and play important roles in the balance of self-renewal, proliferation, and differentiation. Over-expression of Lin28 has been detected in a wide array of malignancies, including colon, breast, kidney, liver, leukemia, and several pediatric embryonal tumors such as Neuroblastoma and Wilms tumor (WT). Wilms tumor is the fourth most common type of childhood cancer and the most common type of pediatric kidney cancer, affecting 1 in 10,000 children in North America. WT is particularly interesting as it arises from multipotent embryonic kidney precursor cells that fail to differentiate, providing a window into the mechanisms of early renal development and potentially into the properties of embryonic kidney stem cells. The general goal of this dissertation project is to inform the molecular pathogenesis of Wilms tumor, and to interrogate the Lin28/let-7 pathway as an exemplar of the large variety of human tumors in which this pathway has been implicated.

项目总结