The Role of Nutrition in the Development/Progression of Alcohol-Induced Organ Injury
营养在酒精引起的器官损伤的发生/进展中的作用
基本信息
- 批准号:10056411
- 负责人:
- 金额:$ 143.7万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-05-15 至 2026-04-30
- 项目状态:未结题
- 来源:
- 关键词:Alcohol abuseAlcoholic Liver DiseasesAlcoholsBrainBroccoli - dietaryButyratesCause of DeathChronicCollaborationsCommunitiesCountryDevelopmentDietary FatsDietary InterventionEducationEnhancersEpigenetic ProcessEthanolFDA approvedFacultyFecesFetal Alcohol Spectrum DisorderFetal Alcohol SyndromeFosteringFunctional disorderFundingFutureGoalsGrantHealth Care CostsImpairmentIndividualIndustryInjuryInstitutionInterdisciplinary StudyInterventionIntestinesKnowledgeLactobacillusLeadLipidsMediatingMediator of activation proteinMorbidity - disease rateNational Institute on Alcohol Abuse and AlcoholismNeural Crest CellNutritionalOrganPathogenesisPreventionPrevention approachPrevention therapyPreventiveProbioticsProteomicsResearchResearch PersonnelResourcesRoleSchool DentistrySignal TransductionSulforaphaneTherapeutic InterventionUnited StatesUnited States National Institutes of HealthUniversitiesVolatile Fatty Acidsalcohol abuse therapyalcohol exposurealcohol interventionalcohol researchalcohol use disorderbasecofactorcohesioncollegeexosomegut bacteriagut-liver axishigh schoolimprovedinflammatory disease of the intestineintestinal barrierliver inflammationmetabolomemetabolomicsmortalitymouse modelmultidisciplinarynanoparticlenew therapeutic targetnovelnutritionorgan injurypreventteratogenesistherapeutic effectivenesstherapeutic target
项目摘要
The University of Louisville Alcohol Research Center (ULARC) was created to serve as a
regional/national resource to perform interdisciplinary collaborative research on the role of nutrition as
a cofactor in alcohol induced organ injury and as a possible therapeutic intervention to prevent/treat
this organ injury. The nutrition and alcohol-induced organ injury theme of the center is unique among
alcohol centers. The approach is highly translational. Our investigators include faculty from 13 departments
and 6 colleges. The Specific Aims of the ULARC are to:
1) perform/facilitate interdisciplinary research on nutrition and alcohol-induced organ injury;
2) serve as a regional/national resource for the study of nutrition and alcohol-induced organ injury;
3) develop potential therapeutic targets/interventions for alcohol induced organ injury based on the
mechanistic research of the ULARC; and
4) disseminate knowledge/interventions to the scientific and lay communities.
We will explore interactions of nutrition and alcohol abuse in the development of alcohol-induced organ
dysfunction, and we will evaluate diverse potential nutritional preventive/therapeutic interventions. Project 1
(Kirpich/McClain) evaluates the role of dietary fat in ALD pathogenesis; Project 2 (Barve) evaluates alcohol-
induced epigenetic alterations in the gut:liver axis. Project 3 (Chen) will elucidate the mechanisms by which
enhancers mediate ethanol-induced developmental impairment of neural crest cells and teratogenesis and
unique exosome treatment for prevention of FASD. Project 4 (Feng) studies the beneficial effects of the
probiotic, Lactobacillus rhamnosis GG (LGG)on the gut:liver axis in ALD.
Together, these projects form a cohesive and interactive approach to investigate the effects of nutrition and
nutritional interventions on alcohol-induced organ injury.
路易斯维尔大学酒精研究中心 (ULARC) 的成立是为了充当
区域/国家资源,以开展跨学科合作研究营养的作用
酒精引起的器官损伤的辅助因子,并作为预防/治疗的可能治疗干预措施
这种器官损伤。该中心的营养和酒精引起的器官损伤主题在同行中是独一无二的。
酒精中心。该方法具有高度转化性。我们的调查员包括来自 13 个系的教师
和6所学院。 ULARC 的具体目标是:
1)进行/促进营养和酒精引起的器官损伤的跨学科研究;
2) 作为营养和酒精引起的器官损伤研究的区域/国家资源;
3)根据酒精引起的器官损伤制定潜在的治疗目标/干预措施
ULARC的机理研究;和
4) 向科学界和非专业界传播知识/干预措施。
我们将探讨营养和酒精滥用在酒精诱发的器官发育中的相互作用
功能障碍,我们将评估各种潜在的营养预防/治疗干预措施。项目1
(Kirpich/McClain) 评估膳食脂肪在 ALD 发病机制中的作用;项目 2 (Barve) 评估酒精-
诱导肠道:肝轴的表观遗传改变。项目 3(陈)将阐明其机制
增强子介导乙醇诱导的神经嵴细胞发育障碍和致畸
用于预防 FASD 的独特外泌体治疗。项目 4(冯)研究了
益生菌、鼠李糖乳杆菌 GG (LGG) 在 ALD 中肠道:肝轴上的作用。
这些项目共同形成了一种有凝聚力和互动的方法来研究营养和营养的影响
营养干预对酒精引起的器官损伤。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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CRAIG J. MCCLAIN其他文献
CRAIG J. MCCLAIN的其他文献
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{{ truncateString('CRAIG J. MCCLAIN', 18)}}的其他基金
Inflammation Resolving Lipid Mediators: Novel Therapy for Alcohol AssociatedLiver Disease
消炎脂质介质:酒精相关性肝病的新疗法
- 批准号:
10590047 - 财政年份:2023
- 资助金额:
$ 143.7万 - 项目类别:
Administrative Supplement to Hepatobiology and Toxicology COBRE
肝生物学和毒理学 COBRE 行政增刊
- 批准号:
10399887 - 财政年份:2021
- 资助金额:
$ 143.7万 - 项目类别:
Alcoholic Hepatitis Network 3/9 University of Louisville
酒精性肝炎网络 3/9 路易斯维尔大学
- 批准号:
9752421 - 财政年份:2018
- 资助金额:
$ 143.7万 - 项目类别:
Alcoholic Hepatitis Network 3/9 University of Louisville
酒精性肝炎网络 3/9 路易斯维尔大学
- 批准号:
10434741 - 财政年份:2018
- 资助金额:
$ 143.7万 - 项目类别:
Alcoholic Hepatitis Network 3/9 University of Louisville
酒精性肝炎网络 3/9 路易斯维尔大学
- 批准号:
10202391 - 财政年份:2018
- 资助金额:
$ 143.7万 - 项目类别:
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