The Role of Nutrition in the Development/Progression of Alcohol-Induced Organ Injury

营养在酒精引起的器官损伤的发生/进展中的作用

• 批准号: 10056411
• 负责人: CRAIG J. MCCLAIN
• 金额: $ 143.7万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-15 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10056411
• 关键词: Alcohol abuse; Alcoholic Liver Diseases; Alcohols; Brain; Broccoli - dietary; Butyrates; Cause of Death; Chronic; Collaborations; Communities; Country; Development; Dietary Fats; Dietary Intervention; Education; Enhancers; Epigenetic Process; Ethanol; FDA approved; Faculty; Feces; Fetal Alcohol Spectrum Disorder; Fetal Alcohol Syndrome; Fostering; Functional disorder; Funding; Future; Goals; Grant; Health Care Costs; Impairment; Individual; Industry; Injury; Institution; Interdisciplinary Study; Intervention; Intestines; Knowledge; Lactobacillus; Lead; Lipids; Mediating; Mediator of activation protein; Morbidity - disease rate; National Institute on Alcohol Abuse and Alcoholism; Neural Crest Cell; Nutritional; Organ; Pathogenesis; Prevention; Prevention approach; Prevention therapy; Preventive; Probiotics; Proteomics; Research; Research Personnel; Resources; Role; School Dentistry; Signal Transduction; Sulforaphane; Therapeutic Intervention; United States; United States National Institutes of Health; Universities; Volatile Fatty Acids; alcohol abuse therapy; alcohol exposure; alcohol intervention; alcohol research; alcohol use disorder; base; cofactor; cohesion; college; exosome; gut bacteria; gut-liver axis; high school; improved; inflammatory disease of the intestine; intestinal barrier; liver inflammation; metabolome; metabolomics; mortality; mouse model; multidisciplinary; nanoparticle; new therapeutic target; novel; nutrition; organ injury; prevent; teratogenesis; therapeutic effectiveness; therapeutic target

The University of Louisville Alcohol Research Center (ULARC) was created to serve as a regional/national resource to perform interdisciplinary collaborative research on the role of nutrition as a cofactor in alcohol induced organ injury and as a possible therapeutic intervention to prevent/treat this organ injury. The nutrition and alcohol-induced organ injury theme of the center is unique among alcohol centers. The approach is highly translational. Our investigators include faculty from 13 departments and 6 colleges. The Specific Aims of the ULARC are to: 1) perform/facilitate interdisciplinary research on nutrition and alcohol-induced organ injury; 2) serve as a regional/national resource for the study of nutrition and alcohol-induced organ injury; 3) develop potential therapeutic targets/interventions for alcohol induced organ injury based on the mechanistic research of the ULARC; and 4) disseminate knowledge/interventions to the scientific and lay communities. We will explore interactions of nutrition and alcohol abuse in the development of alcohol-induced organ dysfunction, and we will evaluate diverse potential nutritional preventive/therapeutic interventions. Project 1 (Kirpich/McClain) evaluates the role of dietary fat in ALD pathogenesis; Project 2 (Barve) evaluates alcohol- induced epigenetic alterations in the gut:liver axis. Project 3 (Chen) will elucidate the mechanisms by which enhancers mediate ethanol-induced developmental impairment of neural crest cells and teratogenesis and unique exosome treatment for prevention of FASD. Project 4 (Feng) studies the beneficial effects of the probiotic, Lactobacillus rhamnosis GG (LGG)on the gut:liver axis in ALD. Together, these projects form a cohesive and interactive approach to investigate the effects of nutrition and nutritional interventions on alcohol-induced organ injury.

路易斯维尔大学酒精研究中心（ULARC）的成立是为了作为一个 区域/国家资源，就营养的作用进行跨学科合作研究， 酒精诱导的器官损伤的辅助因子，并作为预防/治疗的可能治疗干预 器官损伤该中心的营养和酒精引起的器官损伤主题是独一无二的， 酒精中心该方法是高度平移的。我们的调查人员包括来自13个部门的教师 6个学院ULARC的具体目标是： 1)开展/促进关于营养和酒精引起的器官损伤的跨学科研究; 2)作为研究营养和酒精引起的器官损伤的区域/国家资源; 3)基于以下方面，开发酒精诱导器官损伤的潜在治疗靶点/干预措施： ULARC的机制研究;以及 4)向科学界和非科学界传播知识/干预措施。 我们将探讨营养和酒精滥用在酒精诱导器官发育中的相互作用 我们将评估各种潜在的营养预防/治疗干预措施。项目1 （Kirpich/McClain）评估了膳食脂肪在ALD发病机制中的作用;项目2（Barve）评估了酒精- 在肠道中诱导表观遗传改变：肝轴。项目3（Chen）将阐明 增强子介导乙醇诱导的神经嵴细胞发育障碍和致畸作用， 独特的外泌体治疗，用于预防FASD。项目4（丰）研究了 益生菌，鼠李糖乳杆菌GG（LGG）在肠道：肝轴ALD。 总之，这些项目形成了一种连贯和互动的方法，以调查营养的影响， 酒精性器官损伤的营养干预。