The Role of Nutrition in the Development/Progression of Alcohol-Induced Organ Injury
营养在酒精引起的器官损伤的发生/进展中的作用
基本信息
- 批准号:10056411
- 负责人:
- 金额:$ 143.7万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-05-15 至 2026-04-30
- 项目状态:未结题
- 来源:
- 关键词:Alcohol abuseAlcoholic Liver DiseasesAlcoholsBrainBroccoli - dietaryButyratesCause of DeathChronicCollaborationsCommunitiesCountryDevelopmentDietary FatsDietary InterventionEducationEnhancersEpigenetic ProcessEthanolFDA approvedFacultyFecesFetal Alcohol Spectrum DisorderFetal Alcohol SyndromeFosteringFunctional disorderFundingFutureGoalsGrantHealth Care CostsImpairmentIndividualIndustryInjuryInstitutionInterdisciplinary StudyInterventionIntestinesKnowledgeLactobacillusLeadLipidsMediatingMediator of activation proteinMorbidity - disease rateNational Institute on Alcohol Abuse and AlcoholismNeural Crest CellNutritionalOrganPathogenesisPreventionPrevention approachPrevention therapyPreventiveProbioticsProteomicsResearchResearch PersonnelResourcesRoleSchool DentistrySignal TransductionSulforaphaneTherapeutic InterventionUnited StatesUnited States National Institutes of HealthUniversitiesVolatile Fatty Acidsalcohol abuse therapyalcohol exposurealcohol interventionalcohol researchalcohol use disorderbasecofactorcohesioncollegeexosomegut bacteriagut-liver axishigh schoolimprovedinflammatory disease of the intestineintestinal barrierliver inflammationmetabolomemetabolomicsmortalitymouse modelmultidisciplinarynanoparticlenew therapeutic targetnovelnutritionorgan injurypreventteratogenesistherapeutic effectivenesstherapeutic target
项目摘要
The University of Louisville Alcohol Research Center (ULARC) was created to serve as a
regional/national resource to perform interdisciplinary collaborative research on the role of nutrition as
a cofactor in alcohol induced organ injury and as a possible therapeutic intervention to prevent/treat
this organ injury. The nutrition and alcohol-induced organ injury theme of the center is unique among
alcohol centers. The approach is highly translational. Our investigators include faculty from 13 departments
and 6 colleges. The Specific Aims of the ULARC are to:
1) perform/facilitate interdisciplinary research on nutrition and alcohol-induced organ injury;
2) serve as a regional/national resource for the study of nutrition and alcohol-induced organ injury;
3) develop potential therapeutic targets/interventions for alcohol induced organ injury based on the
mechanistic research of the ULARC; and
4) disseminate knowledge/interventions to the scientific and lay communities.
We will explore interactions of nutrition and alcohol abuse in the development of alcohol-induced organ
dysfunction, and we will evaluate diverse potential nutritional preventive/therapeutic interventions. Project 1
(Kirpich/McClain) evaluates the role of dietary fat in ALD pathogenesis; Project 2 (Barve) evaluates alcohol-
induced epigenetic alterations in the gut:liver axis. Project 3 (Chen) will elucidate the mechanisms by which
enhancers mediate ethanol-induced developmental impairment of neural crest cells and teratogenesis and
unique exosome treatment for prevention of FASD. Project 4 (Feng) studies the beneficial effects of the
probiotic, Lactobacillus rhamnosis GG (LGG)on the gut:liver axis in ALD.
Together, these projects form a cohesive and interactive approach to investigate the effects of nutrition and
nutritional interventions on alcohol-induced organ injury.
路易斯维尔大学酒精研究中心(ULARC)的成立是为了作为一个
区域/国家资源,就营养的作用进行跨学科合作研究,
酒精诱导的器官损伤的辅助因子,并作为预防/治疗的可能治疗干预
器官损伤该中心的营养和酒精引起的器官损伤主题是独一无二的,
酒精中心该方法是高度平移的。我们的调查人员包括来自13个部门的教师
6个学院ULARC的具体目标是:
1)开展/促进关于营养和酒精引起的器官损伤的跨学科研究;
2)作为研究营养和酒精引起的器官损伤的区域/国家资源;
3)根据酒精引起的器官损伤,开发潜在的治疗靶点/干预措施
ULARC的机制研究;以及
4)向科学界和非科学界传播知识/干预措施。
我们将探讨营养和酒精滥用在酒精诱导器官发育中的相互作用
我们将评估各种潜在的营养预防/治疗干预措施。项目1
(Kirpich/McClain)评估了膳食脂肪在ALD发病机制中的作用;项目2(Barve)评估了酒精-
在肠道中诱导表观遗传改变:肝轴。项目3(Chen)将阐明
增强子介导乙醇诱导的神经嵴细胞发育障碍和致畸作用,
独特的外泌体治疗,用于预防FASD。项目4(丰)研究了
益生菌,鼠李糖乳杆菌GG(LGG)在肠道:肝轴ALD。
总之,这些项目形成了一种连贯和互动的方法,以调查营养的影响,
酒精性器官损伤的营养干预。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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CRAIG J. MCCLAIN其他文献
CRAIG J. MCCLAIN的其他文献
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{{ truncateString('CRAIG J. MCCLAIN', 18)}}的其他基金
Inflammation Resolving Lipid Mediators: Novel Therapy for Alcohol AssociatedLiver Disease
消炎脂质介质:酒精相关性肝病的新疗法
- 批准号:
10590047 - 财政年份:2023
- 资助金额:
$ 143.7万 - 项目类别:
Administrative Supplement to Hepatobiology and Toxicology COBRE
肝生物学和毒理学 COBRE 行政增刊
- 批准号:
10399887 - 财政年份:2021
- 资助金额:
$ 143.7万 - 项目类别:
Alcoholic Hepatitis Network 3/9 University of Louisville
酒精性肝炎网络 3/9 路易斯维尔大学
- 批准号:
9752421 - 财政年份:2018
- 资助金额:
$ 143.7万 - 项目类别:
Alcoholic Hepatitis Network 3/9 University of Louisville
酒精性肝炎网络 3/9 路易斯维尔大学
- 批准号:
10434741 - 财政年份:2018
- 资助金额:
$ 143.7万 - 项目类别:
Alcoholic Hepatitis Network 3/9 University of Louisville
酒精性肝炎网络 3/9 路易斯维尔大学
- 批准号:
10202391 - 财政年份:2018
- 资助金额:
$ 143.7万 - 项目类别:
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