FASEB's "The Lipid Droplets Conference"

项目摘要 第七届FASE B关于脂滴的夏季研究会议，题为《脂滴与健康和 疾病，“将重点放在快速发展的脂滴生物学领域。脂滴是动态的细胞 在能量代谢中起关键作用的细胞器。脂滴堆积和功能障碍是其特征 代谢性疾病，包括肥胖、脂肪营养不良、胰岛素抵抗、糖尿病、非酒精性脂肪肝 疾病和心血管疾病。它们越来越多地被研究在癌症的背景下。 新陈代谢、神经退化和免疫也是如此。代谢性疾病日益盛行 全世界都更加迫切地鼓励对脂类的基本方面的研究 液滴的形成、生长、移动、成熟和降解以及脂滴如何影响细胞、组织和生物体 生理学和致病因素。对这些概念的理解是设计基本原理所必需的 适当的新治疗策略。 会议将于2020年7月5日至8日在科罗拉多州斯诺马斯的斯诺马斯韦斯顿酒店举行。这个 形式包括Tobias Walther在开幕式当晚的主旨演讲，受邀演讲者的六次演讲， 以及从提交的摘要中挑选出来的实习生和早期职业调查人员的简短演讲，三张海报 会议，关于职业设计和平衡的职业讲习班，以及关于高级 成像显微镜。会议形式将鼓励和促进受训者之间的互动，尽早 职业调查员和老牌调查员。科学会议涵盖了脂滴的全部范围 生物学，从生物物理、生化和细胞主题到生理学和疾病。来自国际的洽谈 知名研究人员将跨越基础研究到临床研究，并描述不同的方法(生物物理学， 遗传学、生物化学、细胞生物学、生理学)和模型(小鼠、人类、培养细胞、苍蝇、酵母)。这 会议继续代表专门讨论脂滴问题的主要国际会议 仍然是研究人员交流思想和分享突破性成果的独特论坛 及时场。 这次会议的一个中心目标是培养和鼓励下一代科学家。这 申请申请资助14名研究生、博士后研究员和早期 职业调查员，包括妇女、任职人数不足的少数群体和残疾人，他们将 从提交的被评为优秀的摘要中挑选出来。私密的会议形式，隐蔽的会议 以及参与者之间非正式互动的许多机会，无论是计划内的还是计划外的，都将 为年轻的研究人员提供机会介绍他们的工作，从该领域的领导人那里获得反馈， 并寻求职业建议。

Project Summary The 7th FASEB Summer Research Conference on Lipid Droplets, entitled “Lipid Droplets in Health and Disease,” will focus on the rapidly developing field of lipid droplet biology. Lipid droplets are dynamic cellular organelles that play key roles in energy metabolism. Lipid droplet accumulation and dysfunction are hallmarks of metabolic diseases, including obesity, lipodystrophy, insulin resistance, diabetes, nonalcoholic fatty liver disease, and cardiovascular disease. They are increasingly being studied in the contexts of cancer metabolism, neurodegeneration and immunity as well. The increasing prevalence of metabolic disorders throughout the world lends increased urgency to encouraging research into fundamental aspects of how lipid droplets form, grow, move, mature, and degrade and how lipid droplets influence cell, tissue and organismal physiology and contribute to disease. Understanding of these concepts is necessary for the rationale design appropriate new therapeutic strategies. The conference will be held from July 5-8, 2020 at the Snowmass Weston Hotel in Snowmass, CO. The format includes an opening night keynote address by Tobias Walther, six sessions of talks by invited speakers, as well as short talks by trainees and early career investigators selected from submitted abstracts, three poster sessions, a Career Workshop on career design and balance, and a Meet the Experts session on advanced imaging microscopy. The meeting format will encourage and facilitate interactions between trainees, early career investigators and established investigators. The scientific sessions cover the full breadth of lipid-droplet biology, from biophysical, biochemical, and cellular topics to physiology and disease. Talks from internationally renowned researchers will span basic to clinical research and describe diverse approaches (biophysics, genetics, biochemistry, cell biology, physiology) and models (mice, humans, cultured cells, flies, yeast). This meeting continues to represent THE major international meeting dedicated exclusively to lipid droplets and remains a unique forum for researchers to exchange ideas and share breaking results in this dynamic and timely field. A central aim of this conference is training and encouraging the next generation of scientists. This application requests funding to support the participation of 14 graduate students, postdoctoral fellows and early career investigators, including women, underrepresented minorities, and persons with disabilities, who will be chosen from submitted abstracts judged as superior. The intimate conference format, the secluded conference site, and the many opportunities for informal interactions between participants, planned and unplanned, will provide young investigators opportunities to present their work, to obtain feedback from leaders in the field, and to get career advice.