FASEB's "The Translational Neuroimmunology Conference: From Mechanisms to Therapeutics."

摘要(最多30行)： 本R13意见书的目的是为受训人员和有限数量的初级学员申请资金 调查员发言者和来自STEM领域传统上代表性较低的团体的发言者参加 2020年FASE B科学研究会议：翻译神经免疫学会议 治疗学的机制。这将是第15届FASE B神经免疫学会议，将在 巴布森行政会议中心，2020年7月19日至23日。上一次FASB会议是在斯诺马斯举行的， 2018年，本杰明·西格尔博士被选为联合主席，与托马斯·莱恩博士合作 2018年担任联席主席，2020年担任主席。2020年的会议是在前几届会议的基础上发展起来的 聚集了一群不同的神经学家、免疫学家、临床医生、微生物学家、翻译家 和基础研究科学家在一个场所和一个促进个人与 不同的专业知识和不同的职业阶段。此前的评估对这次会议的评价很高 杰出的演讲和讨论时间，适合在会议期间留下来的有影响力的演讲者 会议，初级科学家和研究生的摘要精选，用于简短的平台演讲， 出席人数众多的海报会议，演讲者和与会者之间免费和公开讨论的时间，旨在 促进新的和持续的合作。2020年的计划旨在定义 中枢神经系统中的神经免疫相互作用，因为它与新出现的话题有关，包括认知性的作用 染色体和神经炎症，并评估先天免疫反应在 神经退行性变。我们还寻求探索利用神经免疫的机会和挑战。 相互作用作为治疗包括多发性硬化症在内的经典神经学和神经退行性疾病的方法， 阿尔茨海默病、脊髓损伤、胶质母细胞瘤和中枢神经系统自身免疫性疾病。作为对.的回应 参加2018年会议的实习生和初级调查人员的评估请求，今年是新的 增加了两个讲习班，讨论务实问题和职业生涯，目的是在发现之路上搭建桥梁 人类疗法和科学严谨性在赠款准备和出版中的作用。总的来说， 这次会议的具体目标是：1)提供一个论坛，展示未发表的、前沿的 来自不同领域的研究人员对中枢神经系统健康和疾病的神经免疫调节的研究； 2)提供论坛，正式和非正式讨论互补领域的成果如何取得进展 我们对神经免疫相互作用如何支持中枢神经系统功能和健康的理解 被遗传、病原体、毒物和行为改变以驱动疾病病理，以及3)确保 培养和整合来自不同背景的青年调查员和那些传统上在以下领域工作的人 以有意义和互动的方式将这些领域的代表纳入更广泛的研究社区。 总之，与会者将享受到一个由多学科研究人员组成的团队，这些研究人员是在其他专业机构找不到的 会议，并将受益于对翻译研究的机遇和挑战的关注 对疗法的发现。

Abstract (30 lines max): The purpose of this R13 submission is to request funds for trainees and for a limited number of junior investigator speakers and those from groups traditionally underrepresented in the STEM fields to participate in the 2020 FASEB Science Research Conference: The Translational Neuroimmunology Conference: from mechanisms to therapeutics. This will be the 15th FASEB Neuroimmunology conference and will be held at the Babson Executive Conference Center from July 19-23, 2020. The last FASEB meeting was held in Snowmass, CO in 2018, where Dr. Benjamin Segal was elected as co-chair to work with Dr. Thomas Lane who was the 2018 co-chair and is the 2020 chair. The 2020 conference builds upon the excellence of previous meetings and brings together a diverse group of neuroscientists, immunologists, clinicians, microbiologists, translational and basic research scientists at a venue and with a program fostering interaction between individuals with different expertise and at different career stages. Previous evaluations have ranked this conference highly for outstanding presentations and discussion time, for high impact speakers who remain for the duration of the conference, selection of abstracts from junior scientists and graduate trainees for short platform presentations, well-attended poster sessions, time for free and open discussions between speakers and attendees aimed at fostering new and ongoing collaborations. The 2020 program is aimed at defining the contributions of neuroimmune interactions in CNS as it relates to emerging topics including understanding the role of sex chromosomes and neuroinflammation and assessing the role of the innate immune response in neurodegeneration. We also seek to explore the opportunities and challenges for harnessing neuroimmune interactions as therapies for classic neurologic and neurodegenerative diseases including multiple sclerosis, Alzheimer’s disease, spinal cord injury, glioblastoma and CNS autoimmune diseases. In response to evaluation requests from trainees and junior investigators attending the 2018 conference, new this year are addition of two workshops discussing pragmatic issues and careers aimed at bridging pathways from discovery to human therapies and the role of scientific rigor in grant preparation and publication. In aggregate, the specific goals of this conference are to: 1) provide a forum for the presentation of unpublished, cutting-edge research by investigators from diverse fields applicable to neuroimmune regulation of CNS health and disease; 2) provide forums for both formal and informal discussions on how results from complementary fields advance our understanding of how neuroimmune interactions support CNS function and health lifelong and can be modified by genetics, pathogens, toxicants and behavior to drive disease pathology, and 3) ensure development and integration of young investigators from diverse backgrounds and those traditionally under- represented in these fields into the broader research community in a meaningful and interactive way. Altogether, attendees will enjoy a multidisciplinary group of researchers not found together at other specialized conferences and will benefit from the focus on the opportunities & challenges in translating research discoveries to therapies.