SOMMA-BRAIN

索玛脑

• 批准号: 10065711
• 负责人: STEVEN RON CUMMINGS
• 金额: $ 32.57万
• 依托单位: CALIFORNIA PACIFIC MED CTR RES INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-15 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10065711
• 关键词: Adult; Aging; Applications Grants; Biopsy; Brain; Characteristics; Data; Elderly; Eligibility Determination; Fatigue; Goals; Image; Measures; Muscle; Participant; Peripheral; Prevention; Process; Property; Quality of life; Time; Walking; clinical center; cognitive performance; disability; meter; muscle aging; neuroimaging; novel; prevent; resilience

We propose to acquire new neuroimaging measures concurrent with muscle measures in 40 adults participating in the Pittsburgh Clinical Center R01AG059416, “Study of Muscle and Mobility in Aging (SOMMA). The goal of SOMMA is to study muscle aging as it relates to disability. The goal of the proposed expanded SOMMA-BRAIN is to identify, for the first time, novel modifiable shared brain-muscle energy characteristics best predicting resilience to fatigue and loss of mobility. By promoting an integrated study of central and peripheral causes of fatigue, this project will provide novel targets for prevention and treatment of fatigue. Additionally, this project would discover modifiable processes in muscle that may influence processes in the brain to, in turn, influence cognitive performance. The data would support a new grant application to NIA to expand the aims of SOMMA, as well as the number of participants and widen the eligibility criteria.

我们建议在 40 年内同时获得新的神经影像学测量和肌肉测量 参加匹兹堡临床中心 R01AG059416 的成人，“肌肉和肌肉的研究” 老龄化流动性（SOMMA）。 SOMMA 的目标是研究肌肉衰老，因为它与 残疾。拟议的扩展 SOMMA-BRAIN 的目标是首次确定， 新型可修改共享脑肌肉能量特征最能预测疲劳恢复能力 和丧失行动能力。通过促进对中枢和外周原因的综合研究 疲劳，该项目将为预防和治疗疲劳提供新的靶点。 此外，该项目将发现肌肉中可能影响的可改变过程 大脑中的过程反过来会影响认知表现。该数据将支持 向 NIA 提出新的拨款申请，以扩大 SOMMA 的目标，以及扩大 SOMMA 的数量 参与者并扩大资格标准。