SOMMA-BRAIN

索玛脑

• 批准号: 10065711
• 负责人: STEVEN RON CUMMINGS
• 金额: $ 32.57万
• 依托单位: CALIFORNIA PACIFIC MED CTR RES INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-15 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10065711
• 关键词: Adult; Aging; Applications Grants; Biopsy; Brain; Characteristics; Data; Elderly; Eligibility Determination; Fatigue; Goals; Image; Measures; Muscle; Participant; Peripheral; Prevention; Process; Property; Quality of life; Time; Walking; clinical center; cognitive performance; disability; meter; muscle aging; neuroimaging; novel; prevent; resilience

We propose to acquire new neuroimaging measures concurrent with muscle measures in 40 adults participating in the Pittsburgh Clinical Center R01AG059416, “Study of Muscle and Mobility in Aging (SOMMA). The goal of SOMMA is to study muscle aging as it relates to disability. The goal of the proposed expanded SOMMA-BRAIN is to identify, for the first time, novel modifiable shared brain-muscle energy characteristics best predicting resilience to fatigue and loss of mobility. By promoting an integrated study of central and peripheral causes of fatigue, this project will provide novel targets for prevention and treatment of fatigue. Additionally, this project would discover modifiable processes in muscle that may influence processes in the brain to, in turn, influence cognitive performance. The data would support a new grant application to NIA to expand the aims of SOMMA, as well as the number of participants and widen the eligibility criteria.

我们建议在40例患者中同时获得新的神经影像学测量和肌肉测量。 参加匹兹堡临床中心R 01 AG 059416“肌肉和 老龄化的流动性（SOMMA）。SOMMA的目标是研究肌肉老化，因为它涉及到 残疾。提出的扩展SOMMA-BRAIN的目标是首次识别， 新的可修改的共享脑肌肉能量特征最好地预测疲劳恢复力 和丧失流动性。通过促进综合研究造成这一现象的中心和外围原因， 疲劳，该项目将为预防和治疗疲劳提供新的靶点。 此外，该项目将发现肌肉中可能影响 大脑中的过程，反过来，影响认知表现。数据将支持一个 新的赠款申请NIA扩大SOMMA的目标，以及数量 参与者和扩大资格标准。