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SOMMA-BRAIN

SOMMA-BRAIN
索玛脑
批准号：
10065711
负责人：
STEVEN RON CUMMINGS
金额：
$32.57万
依托单位：
CALIFORNIA PACIFIC MED CTR RES INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
项目状态：
已结题
起止时间：
2018-06-15 至 2023-05-31
来源：
https://reporter.nih.gov/project-details/10065711
关键词：
AdultAgingApplications GrantsBiopsyBrainCharacteristicsDataElderlyEligibility DeterminationFatigueGoalsImageMeasuresMuscleParticipantPeripheralPreventionProcessPropertyQuality of lifeTimeWalkingclinical centercognitive performancedisabilitymetermuscle agingneuroimagingnovelpreventresilience

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中文摘要
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英文摘要
We propose to acquire new neuroimaging measures concurrent with muscle measures in 40 adults participating in the Pittsburgh Clinical Center R01AG059416, “Study of Muscle and Mobility in Aging (SOMMA). The goal of SOMMA is to study muscle aging as it relates to disability. The goal of the proposed expanded SOMMA-BRAIN is to identify, for the first time, novel modifiable shared brain-muscle energy characteristics best predicting resilience to fatigue and loss of mobility. By promoting an integrated study of central and peripheral causes of fatigue, this project will provide novel targets for prevention and treatment of fatigue. Additionally, this project would discover modifiable processes in muscle that may influence processes in the brain to, in turn, influence cognitive performance. The data would support a new grant application to NIA to expand the aims of SOMMA, as well as the number of participants and widen the eligibility criteria.
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