SOMMA-BRAIN

我们建议在40个月中获得与肌肉测量同时进行的新的神经成像测量 参加匹兹堡临床中心的成年人R01AG059416，“肌肉和 老龄化中的机动性(Somma)。Somma的目标是研究肌肉老化，因为它与 残疾。拟议中的扩大索玛大脑的目标是首次识别， 新的可修改的共享脑-肌肉能量特征最能预测疲劳恢复能力 以及失去机动性。通过促进对中枢和外周病因的综合研究 对于疲劳，该项目将为预防和治疗疲劳提供新的目标。 此外，这个项目将发现肌肉中可能影响 大脑中的过程反过来影响认知表现。该数据将支持 向国家投资局提出新的赠款申请，以扩大Somma的目标，以及 参与者，并扩大资格标准。

We propose to acquire new neuroimaging measures concurrent with muscle measures in 40 adults participating in the Pittsburgh Clinical Center R01AG059416, “Study of Muscle and Mobility in Aging (SOMMA). The goal of SOMMA is to study muscle aging as it relates to disability. The goal of the proposed expanded SOMMA-BRAIN is to identify, for the first time, novel modifiable shared brain-muscle energy characteristics best predicting resilience to fatigue and loss of mobility. By promoting an integrated study of central and peripheral causes of fatigue, this project will provide novel targets for prevention and treatment of fatigue. Additionally, this project would discover modifiable processes in muscle that may influence processes in the brain to, in turn, influence cognitive performance. The data would support a new grant application to NIA to expand the aims of SOMMA, as well as the number of participants and widen the eligibility criteria.