New Nanoparticle Strategies for Efficient Delivery and Controlled Release into the Brain

治疗神经退行性疾病的一个关键挑战是药物通过血脑屏障（BBB）的输送。本项目将在系统研究血脑屏障渗透机制和近红外药物控释策略的基础上，研制先进的血脑屏障“纳米穿梭体”。这些输送系统可能有助于脑部疾病的诊断，并按需向脑部病变细胞释放药物，为脑部疾病的全新局部治疗提供了潜力。

A key challenge for treating neurodegenerative diseases is delivery of drugs across the blood–brain barrier (BBB). This project will develop advanced BBB “nanoshuttles” based upon systematic investigation of BBB penetration mechanisms and near-infrared drug controlled release strategy. These delivery systems may facilitate diagnosis of brain diseases and on-demand release of drug cargos to diseased cells in the brain, offering the potential of a brand new localised therapy for brain diseases.