Integration of acoustic and electric hearing within or across ears

耳内或耳外声学和电学听力的集成

• 批准号: 10056216
• 负责人: Qian-Jie Fu
• 金额: $ 33.15万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-12-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10056216
• 关键词: Acoustic Stimulation; Acoustics; Adverse effects; Affect; Auditory; Binaural; Clinic; Clinical; Cochlea; Cochlear Implants; Contralateral; Data; Devices; Ear; Electric Stimulation; Electrodes; Emotions; Frequencies; Goals; Hearing; Hearing Aids; Ipsilateral; Light; Measures; Noise; Patients; Pattern; Performance; Research; Residual state; Resolution; Speech; base; experience; experimental study; hearing impairment; improved; insight; interest; normal hearing; radiological imaging; relating to nervous system; signal processing; simulation; sound

SUMMARY: Increasing numbers of cochlear implant (CI) patients are able to combine residual acoustic hearing (AH) with electric hearing (EH) in the same ear (electric-acoustic stimulation, or EAS), across ears (bimodal), or both (biEAS). The benefits of acoustic-electric hearing (AEH) are variable; some CI users even experience interference between acoustic and electric stimulation patterns. In the clinic, there is little effort to optimize CI and/or hearing aid signal processing with regard to combined acoustic and electric hearing, and it is unclear whether acoustic and electric patterns are combined differently within or across ears. EAS and biEAS patients may experience energetic interference between the current spread from EH and the spread of excitation (SOE) from AH. Bimodal, EAS, and biEAS patients may also experience informational interference because the same acoustic input may be delivered to different cochlear places (tonotopic mismatch) within and/or across ears. To mitigate these adverse effects, the optimal fitting for CI and/or hearing aid devices might be quite different for AEH than for EH and/or AH. The long-term goals of this proposal are to understand the mechanisms that underlie integration of acoustic and electric hearing, which can be used to improve AEH benefits for CI users. We hypothesize that acoustic and electric stimulation patterns are integrated differently within and across ears. Specifically, we hypothesize that integration for EAS listeners is limited by both energetic and informational interference; reducing the current spread/SOE between AH and EH and reducing tonotopic mismatch may improve integration. We also hypothesize that integration for bimodal listeners is limited by informational interference, due to tonotopic mismatch and sound quality differences across ears; improving the sound quality of EH (e.g., focused stimulation) while reducing the tonotopic mismatch between AH and EH may improve integration. Acoustic-electric integration will be evaluated in pairs of parallel experiments with normal-hearing (NH) subjects listening to simulations of AEH and in real EAS, bimodal, and biEAS CI listeners. Speech measures (vowel and sentence recognition in quiet and in noise, vocal emotion recognition) and frequency resolution will be collected with AH, EH, and AEH, and evaluated in terms of overall AEH performance, AEH benefit (performance difference between AEH and AH or EH), and integration efficiency (the ratio between observed and predicted AEH performance). Aim 1 will primarily explore aspects of electric hearing that affect acoustic-electric integration while Aim 2 will focus on aspects of acoustic hearing that affect acoustic-electric integration. The proposed research is of great theoretical interest, as it will provide greater insight into acoustic-electric integration for AEH. The proposed research is also of great clinical value, as the results may provide better guidance for optimizing CI signal processing for AEH.

摘要：越来越多的人工耳蜗植入（CI）患者能够将联合收割机的残余声 听觉（AH）与电听觉（EH）在同一耳朵（电声刺激，或EAS），跨耳 （双峰）或两者（双EAS）。声电听力（AEH）的好处是可变的;一些CI用户甚至 会经历声刺激和电刺激模式之间的干扰。在诊所里， 为了优化关于组合的声学和电听觉的CI和/或助听器信号处理， 并且不清楚声学和电模式是否在耳朵内或在耳朵上不同地组合。EAS 并且biEAS患者可能经历来自EH的电流传播和来自EHF的电流传播之间的能量干扰。 从AH的激励扩展（SOE）。双峰、EAS和biEAS患者也可能发生信息性 因为相同的声学输入可以被传递到不同的耳蜗位置（音调位置 不匹配）。为了减轻这些不利影响，CI和/或 助听器设备对于AEH可能与对于EH和/或AH完全不同。 本建议的长期目标是了解整合的机制， 听觉和电听觉，可用于改善CI用户的AEH益处。我们假设 声和电刺激模式在耳内和耳间不同地集成。我们特别 假设EAS听众的整合受到能量和信息干扰的限制; 降低AH和EH之间的电流扩展/SOE并降低色调失配可以改善 一体化我们还假设双模听众的整合受到信息干扰的限制， 由于音调不匹配和耳朵之间的音质差异;改善EH的音质 (e.g.,聚焦刺激），同时减少AH和EH之间的音调不匹配， 一体化声电整合将在听力正常的成对平行实验中进行评估 (NH)受试者听模拟的AEH和在真实的EAS，双峰，和biEAS CI听众。讲话 测量（安静和噪音中的元音和句子识别，语音情感识别）和频率 分辨率将与AH、EH和AEH一起收集，并根据AEH的总体性能进行评估，AEH 效益（AEH与AH或EH之间的性能差异）和整合效率（AEH与AH或EH之间的比率） 观察和预测AEH性能）。目标1将主要探讨影响电听觉的方面 目标2将侧重于影响声电集成的声学听力方面， 一体化拟议的研究具有很大的理论意义，因为它将提供更深入的了解， AEH声电一体化。这项研究也具有很大的临床价值， 可以为AEH的CI信号处理优化提供更好的指导。